PDB: 117 件ウェブページステータス検索Chemie searchBIRD

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10MH	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET 分子名称: DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ... 著者 Sheikhnejad, G, Brank, A, Christman, J.K, Goddard, A, Alvarez, E, Ford Junior, H, Marquez, V.E, Marasco, C.J, Sufrin, J.R, O'Gara, M, Cheng, X. 登録日 1998-08-10 公開日 1999-02-09 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. J.Mol.Biol., 285, 1999
8MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX 分子名称: 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... 著者 O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. 登録日 1998-08-06 公開日 1998-11-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
3MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY 分子名称: DNA (5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ... 著者 O'Gara, M, Klimasauskas, S, Roberts, R.J, Cheng, X. 登録日 1996-07-24 公開日 1997-01-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J.Mol.Biol., 261, 1996
5LOD	Crystal structure of HhaI DNA methyltransferase in APO form 分子名称: Modification methylase HhaI, SULFATE ION 著者 Rondelet, G, Wouters, J. 登録日 2016-08-09 公開日 2017-08-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem, 9, 2017
5YX2	Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites 分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-12-01 公開日 2018-01-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.653 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
3UBT	Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA 分子名称: 5'-D(*TP*GP*GP*CP*CP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Verdine, G.L, Didovyk, A. 登録日 2011-10-24 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase. J.Biol.Chem., 287, 2012
6FDF	Crystal structure of S. pombe Dnmt2 methyltransferase 分子名称: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase 著者 Johannsson, S, Neumann, P, Ficner, R. 登録日 2017-12-22 公開日 2018-06-20 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Sci Rep, 8, 2018
6F57	Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA 分子名称: DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*ZP*GP*CP*TP*CP*T)-3'), DNA (cytosine-5)-methyltransferase 3-like, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-12-01 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.098 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
5MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH HEMIMETHYLATED DNA AND ADOHCY 分子名称: DNA (5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ... 著者 Cheng, X. 登録日 1996-10-22 公開日 1997-07-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. J.Mol.Biol., 263, 1996
3EEO	M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. 分子名称: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ... 著者 Porta, J.C, Christman, J.K, Borgstahl, G.E.O. 登録日 2008-09-05 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. To be Published
6BRR	Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites 分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-11-30 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
1M0E	ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE 分子名称: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ... 著者 Zhou, L, Cheng, X, Connolly, B.A, Dickman, M.J, Hurd, P.J, Hornby, D.P. 登録日 2002-06-12 公開日 2002-09-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES J.MOL.BIOL., 321, 2002
1MHT	COVALENT TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE, DNA AND S-ADENOSYL-L-HOMOCYSTEINE 分子名称: DNA (5'-D(*TP*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*AP*GP*(C36)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ... 著者 Cheng, X. 登録日 1994-12-08 公開日 1995-06-03 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 HhaI methyltransferase flips its target base out of the DNA helix. Cell(Cambridge,Mass.), 76, 1994
1SKM	HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site 分子名称: 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', 5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', Modification methylase HhaI, ... 著者 Horton, J.R, Ratner, G, Banavali, N, Huang, N, Marquez, V.E, MacKerell, A.D, Cheng, X. 登録日 2004-03-05 公開日 2004-08-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase Nucleic Acids Res., 32, 2004
5CIY	Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain 分子名称: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ... 著者 Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. 登録日 2015-07-13 公開日 2016-03-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
1SVU	Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions 分子名称: Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Dong, A, Zhou, L, Zhang, X, Stickel, S, Roberts, R.J, Cheng, X. 登録日 2004-03-30 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions Biol.Chem., 385, 2004
3G7U	Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) 分子名称: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL 著者 Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-02-10 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published
4MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH NATIVE DNA AND ADOHCY 分子名称: DNA (5'-D(*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ... 著者 Cheng, X. 登録日 1996-07-24 公開日 1997-01-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J.Mol.Biol., 261, 1996
2HMY	BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE 分子名称: PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE 著者 O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. 登録日 1999-02-08 公開日 1999-03-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J.Mol.Biol., 287, 1999
2HR1	Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy 分子名称: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ... 著者 Shieh, F. 登録日 2006-07-19 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI. J.Mol.Biol., 362, 2006
4H0N	Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant 分子名称: CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE 著者 Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. 登録日 2012-09-09 公開日 2012-11-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.712 Å) 主引用文献 Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol, 5, 2013
2I9K	Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI 分子名称: 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE 著者 Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. 登録日 2006-09-05 公開日 2006-10-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
7X9D	DNMT3B in complex with harmine 分子名称: 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B 著者 Cho, C.-C, Yuan, H.S. 登録日 2022-03-15 公開日 2023-03-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18, 2023
4ONJ	Crystal structure of the catalytic domain of ntDRM 分子名称: DNA methyltransferase, SINEFUNGIN 著者 Du, J, Patel, D.J. 登録日 2014-01-28 公開日 2014-06-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.807 Å) 主引用文献 Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
4ONQ	Crystal structure of ntDRM E283S/R309S/F310S/Y590S/D591S mutant 分子名称: DNA methyltransferase, SINEFUNGIN 著者 Du, J, Patel, D.J. 登録日 2014-01-28 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014

 

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