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1CIT	DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B 分子名称: DNA (5'-D(*CP*CP*GP*AP*AP*AP*AP*GP*GP*TP*CP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*GP*AP*CP*CP*TP*TP*TP*TP*CP*GP*G)-3'), PROTEIN (ORPHAN NUCLEAR RECEPTOR NGFI-B), ... 著者 Meinke, G, Sigler, P.B. 登録日 1999-04-05 公開日 1999-05-03 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nat.Struct.Biol., 6, 1999
8CEF	Asymmetric Dimerization in a Transcription Factor Superfamily is Promoted by Allosteric Interactions with DNA 分子名称: DNA (26-MER), Nuclear receptor DNA binding domain, ZINC ION 著者 Patel, A.K.M, Shaik, T.B, McEwen, A.G, Moras, D, Klaholz, B.P, Billas, I.M.L. 登録日 2023-02-01 公開日 2023-08-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.486 Å) 主引用文献 Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA. Nucleic Acids Res., 51, 2023
1YNW	Crystal Structure of Vitamin D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element 分子名称: 5'-d(*TP*TP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*AP*A)-3', 5'-d(*TP*TP*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*A)-3', Retinoic acid receptor RXR-alpha, ... 著者 Shaffer, P.L, Gewirth, D.T. 登録日 2005-01-25 公開日 2005-02-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural analysis of RXR-VDR interactions on DR3 DNA J.Steroid Biochem.Mol.Biol., 89-90, 2004
3M9E	Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE 分子名称: DNA (5'-D(*AP*TP*TP*GP*AP*CP*CP*TP*CP*AP*GP*CP*TP*GP*AP*GP*GP*TP*CP*AP*AP*T)-3'), Thyroid hormone receptor beta, ZINC ION 著者 Chen, Y. 登録日 2010-03-22 公開日 2010-08-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element. Mol.Endocrinol., 24, 2010
1A6Y	REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX 分子名称: DNA (5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*(5IT)P*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3'), ORPHAN NUCLEAR RECEPTOR NR1D1, ... 著者 Zhao, Q, Khorasanizadeh, S, Rastinejad, F. 登録日 1998-03-04 公開日 1998-10-21 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural elements of an orphan nuclear receptor-DNA complex. Mol.Cell, 1, 1998
4TNT	Structure of the human mineralocorticoid receptor in complex with DNA 分子名称: DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), Mineralocorticoid receptor, ... 著者 Hudson, W.H, Ortlund, E.A. 登録日 2014-06-04 公開日 2014-09-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3938 Å) 主引用文献 Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. Plos One, 9, 2014
1BY4	STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA 分子名称: DNA (5'-D(*C*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*A)-3'), PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA), ... 著者 Zhao, Q, Chasse, S.A, Devarakonda, S, Sierk, M.L, Ahvazi, B, Sigler, P.B, Rastinejad, F. 登録日 1998-10-22 公開日 2000-01-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of RXR-DNA interactions. J.Mol.Biol., 296, 2000
5L0M	hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex 分子名称: DNA (5'-D(*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*G)-3'), GLYCEROL, ... 著者 Tuntland, M.L, Ortlund, E.A. 登録日 2016-07-27 公開日 2016-11-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). J. Mol. Biol., 428, 2016
5KRB	GCNF DNA Binding Domain - Oct4 DR0 Complex 分子名称: DNA (5'-D(*AP*GP*AP*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*CP*TP*CP*T)-3'), Nuclear receptor subfamily 6 group A member 1, ... 著者 Weikum, E.R, Ortlund, E.A. 登録日 2016-07-07 公開日 2016-11-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). J. Mol. Biol., 428, 2016
8HBM	Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA 分子名称: Bile acid receptor, DNA (5'-D(P*CP*CP*GP*AP*GP*GP*TP*CP*AP*AP*TP*GP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*CP*GP*AP*GP*GP*TP*CP*AP*TP*TP*GP*AP*CP*CP*TP*CP*G)-3'), ... 著者 Jiang, L, Chen, Y. 登録日 2022-10-29 公開日 2023-06-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA Comput Struct Biotechnol J, 21, 2023
2GDA	REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN 分子名称: GLUCOCORTICOID RECEPTOR, ZINC ION 著者 Baumann, H, Paulsen, K, Kovacs, H, Berglund, H, Wright, A.P.H, Gustafsson, J.-A, Hard, T. 登録日 1994-03-15 公開日 1994-06-22 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Refined solution structure of the glucocorticoid receptor DNA-binding domain. Biochemistry, 32, 1993
8IFO	Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter 分子名称: DNA (5'-D(*GP*AP*GP*GP*AP*CP*AP*AP*AP*GP*GP*TP*GP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*CP*AP*CP*CP*TP*TP*TP*GP*TP*CP*CP*TP*C)-3'), Estrogen-related receptor gamma, ... 著者 Xu, T, Zhen, X, Liu, J. 登録日 2023-02-19 公開日 2023-03-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element Biochem.Biophys.Res.Commun., 656, 2023
2HAN	Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter 分子名称: 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP*AP*CP*TP*TP*GP*T)-3', 5'-D(*GP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*AP*AP*CP*CP*CP*TP*T)-3', Ecdysone receptor, ... 著者 Jakob, M, Kolodziejczyk, R, Orlowski, M, Krzywda, S, Kowalska, A, Dutko-Gwozdz, J, Gwozdz, T, Kochman, M, Jaskolski, M, Ozyhar, A. 登録日 2006-06-13 公開日 2007-05-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain. Nucleic Acids Res., 35, 2007
5VA0	Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter 分子名称: DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), Glucocorticoid receptor, ... 著者 Weikum, E.R, Ortlund, E.A. 登録日 2017-03-24 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res., 45, 2017
5VA7	Glucocorticoid Receptor DNA Binding Domain - IL11 AP-1 recognition element Complex 分子名称: DNA (5'-D(*AP*GP*GP*GP*TP*GP*AP*GP*TP*CP*AP*GP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*CP*TP*GP*AP*CP*TP*CP*AP*CP*CP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Weikum, E.R, Ortlund, E.A. 登録日 2017-03-24 公開日 2017-08-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res., 45, 2017
8J54	Crystal structure of RXR/DR2 complex 分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*CP*TP*AP*CP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*GP*TP*AP*GP*GP*TP*CP*AP*TP*G)-3'), Retinoic acid receptor RXR, ... 著者 Chen, Y, Jiang, L. 登録日 2023-04-21 公開日 2024-01-17 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma. Structure, 32, 2024
6FBQ	Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 7.0 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... 著者 McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. 登録日 2017-12-19 公開日 2018-12-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Modulation of RXR-DNA complex assembly by DNA context. Mol. Cell. Endocrinol., 481, 2019
6FBR	Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human MEp DR1 Response Element, pH 4.2 分子名称: DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*TP*GP*GP*GP*TP*CP*AP*AP*AP*GP*TP*TP*CP*AP*TP*C)-3'), DNA (5'-D(*GP*AP*TP*GP*AP*AP*CP*TP*TP*TP*GP*AP*CP*CP*CP*AP*G)-3'), ... 著者 McEwen, A.G, Poussin-Courmontagne, P, Osz, J, Rochel, N. 登録日 2017-12-19 公開日 2018-12-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Modulation of RXR-DNA complex assembly by DNA context. Mol. Cell. Endocrinol., 481, 2019
4HN6	GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex 分子名称: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Youn, C.E, Ortlund, E.A. 登録日 2012-10-18 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.549 Å) 主引用文献 The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
4HN5	GR DNA Binding Domain - TSLP nGRE Complex 分子名称: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Youn, C.E, Ortlund, E.A. 登録日 2012-10-18 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
6L6L	Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements 分子名称: DNA (5'-D(*AP*AP*AP*GP*GP*TP*CP*AP*AP*AP*CP*TP*GP*TP*GP*AP*CP*CP*TP*AP*T)-3'), DNA (5'-D(P*TP*AP*TP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*TP*TP*GP*AP*CP*CP*TP*T)-3'), Nuclear receptor related 1, ... 著者 Jiang, L, Chen, Y. 登録日 2019-10-29 公開日 2019-11-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.781 Å) 主引用文献 Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. J.Biol.Chem., 294, 2019
6L6Q	Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements 分子名称: DNA (5'-D(P*AP*GP*TP*GP*AP*CP*CP*TP*TP*TP*AP*AP*AP*GP*GP*TP*CP*AP*CP*T)-3'), Nuclear receptor related 1, ZINC ION 著者 Jiang, L, Chen, Y. 登録日 2019-10-29 公開日 2019-11-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. J.Biol.Chem., 294, 2019
6LC1	Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter 分子名称: DNA, DNA (25-MER), Nuclear receptor subfamily 4 group A member 1, ... 著者 Jiang, L, Chen, Y. 登録日 2019-11-16 公開日 2019-12-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter. Biochem.Biophys.Res.Commun., 523, 2020
2NLL	RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA 分子名称: DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ... 著者 Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B. 登録日 1996-11-20 公開日 1997-03-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature, 375, 1995
6XWG	Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element 分子名称: CHLORIDE ION, GLYCEROL, RARb2 DR5 Response Element, ... 著者 McEwen, A.G, Poussin-Courmontagne, P, Peluso-Iltis, C, Rochel, N. 登録日 2020-01-23 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR. Nucleic Acids Res., 48, 2020

 

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