PDB: 515 件ウェブページステータス検索Chemie searchBIRD

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8JYI	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid E 分子名称: 7-[5-(2-azanylethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,Ribonuclease H, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
8JYH	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C 分子名称: 7-[5-[(2~{S})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
8JYJ	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid A 分子名称: 7-[5-(2-acetamidoethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
5DZM	HIV-1 Reverse Transcriptase RH domain 分子名称: Ribonuclease H 著者 Pedersen, L.C, London, R.E, Gabel, S.A, Zheng, X.H. 登録日 2015-09-25 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Unfolding the HIV-1 reverse transcriptase RNase H domain - how to lose a molecular tug-of-war. Nucleic Acids Res., 44, 2016
2E4L	Thermodynamic and Structural Analysis of Thermolabile RNase HI from Shewanella oneidensis MR-1 分子名称: Ribonuclease HI 著者 Tadokoro, T, You, D.J, Chon, H, Matsumura, H, Koga, Y, Takano, K, Kanaya, S. 登録日 2006-12-13 公開日 2007-05-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI. Biochemistry, 46, 2007
4E89	Crystal Structure of RnaseH from gammaretrovirus 分子名称: CADMIUM ION, MAGNESIUM ION, RNase H 著者 Kim, J.H, Kim, S.J. 登録日 2012-03-19 公開日 2012-10-17 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H Biosci.Rep., 32, 2012
4Z0U	RNase HI/SSB-Ct complex 分子名称: Ribonuclease H, SSB-Ct Peptide 著者 Petzold, C, Keck, J.L. 登録日 2015-03-26 公開日 2015-04-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity. J.Biol.Chem., 290, 2015
3P1G	Crystal Structure of the Xenotropic Murine Leukemia Virus-Related Virus (XMRV) RNase H Domain 分子名称: MAGNESIUM ION, Xenotropic Murine Leukemia Virus-Related Virus (XMRV) RNase H Domain 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2010-09-30 公開日 2010-10-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase. Antimicrob.Agents Chemother., 56, 2012
3QIO	Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor 分子名称: 3-hydroxy-6-(phenylsulfonyl)quinazoline-2,4(1H,3H)-dione, Gag-Pol polyprotein,Ribonuclease HI,Gag-Pol polyprotein, MANGANESE (II) ION, ... 著者 Lansdon, E.B, Liu, Q. 登録日 2011-01-27 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4011 Å) 主引用文献 Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
3QIN	Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor 分子名称: 2-(3-bromo-4-methoxybenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, Fusion protein of HIV-1 RNase H p15 with engineered E. coli loop, MANGANESE (II) ION, ... 著者 Lansdon, E.B, Kirschberg, T.A. 登録日 2011-01-27 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6967 Å) 主引用文献 Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
3V1O	Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, GLYCEROL, Reverse transcriptase/ribonuclease H p80, ... 著者 Zhou, D, Wlodawer, A. 登録日 2011-12-09 公開日 2012-03-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.876 Å) 主引用文献 Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J.Struct.Biol., 177, 2012
3V1Q	Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus 分子名称: Reverse transcriptase/ribonuclease H p80 著者 Zhou, D, Wlodawer, A. 登録日 2011-12-09 公開日 2012-03-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J.Struct.Biol., 177, 2012
3V1R	Crystal structures of the reverse transcriptase-associated ribonuclease H domain of XMRV with inhibitor beta-thujaplicinol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, MANGANESE (II) ION, ... 著者 Zhou, D, Wlodawer, A. 登録日 2011-12-09 公開日 2012-03-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J.Struct.Biol., 177, 2012
1WSF	Co-crystal structure of E.coli RNase HI active site mutant (D134A*) with Mn2+ 分子名称: MANGANESE (II) ION, Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-05 公開日 2005-02-08 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of Single Mn(2+) Binding Sites Required for Activation of the Mutant Proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray Crystallography J.Mol.Biol., 345, 2005
1WSE	Co-crystal structure of E.coli RNase HI active site mutant (E48A*) with Mn2+ 分子名称: MANGANESE (II) ION, Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-05 公開日 2005-02-08 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification of Single Mn(2+) Binding Sites Required for Activation of the Mutant Proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray Crystallography J.Mol.Biol., 345, 2005
1WSG	Co-crystal structure of E.coli RNase HI active site mutant (E48A/D134N*) with Mn2+ 分子名称: MANGANESE (II) ION, Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-05 公開日 2005-02-08 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of Single Mn(2+) Binding Sites Required for Activation of the Mutant Proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray Crystallography J.Mol.Biol., 345, 2005
1WSI	Crystal structure of E.coli RNase HI active site mutant (E48A/K87A/D134N) 分子名称: Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-07 公開日 2004-11-23 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献
1WSJ	Crystal structure of E.coli RNase HI active site mutant (K87A/H124A) 分子名称: Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-07 公開日 2004-11-23 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献
1WSH	Crystal structure of E.coli RNase HI active site mutant (E48A/K87A) 分子名称: Ribonuclease HI 著者 Tsunaka, Y, Takano, K, Matsumura, H, Yamagata, Y, Kanaya, S. 登録日 2004-11-07 公開日 2004-11-23 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献
2HB5	Crystal Structure of the Moloney Murine Leukemia Virus RNase H Domain 分子名称: MAGNESIUM ION, Reverse transcriptase/ribonuclease H, SULFATE ION 著者 Lim, D, Gregorio, G.G, Bingman, C.A, Martinez-Hackert, E, Hendrickson, W.A, Goff, S.P. 登録日 2006-06-13 公開日 2006-08-29 最終更新日 2023-03-22 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Crystal Structure of the Moloney Murine Leukemia Virus RNase H Domain. J.Virol., 80, 2006
2KW4	Solution NMR Structure of the Holo Form of a Ribonuclease H domain from D.hafniense, Northeast Structural Genomics Consortium Target DhR1A 分子名称: MAGNESIUM ION, Uncharacterized protein 著者 Mills, J.L, Eletsky, A, Hua, J, Belote, R.L, Buchwald, W.A, Ciccosanti, C, Janjua, H, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Northeast Structural Genomics Consortium Target DhR1A To be Published
2KQ2	Solution NMR structure of the apo form of a ribonuclease H domain of protein DSY1790 from Desulfitobacterium hafniense, Northeast Structural Genomics target DhR1A 分子名称: Ribonuclease H-related protein 著者 Mills, J.L, Eletsky, A, Hua, J, Belote, R.L, Buchwald, W.A, Ciccosanti, C, Janjua, H, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) 登録日 2009-10-24 公開日 2010-03-16 最終更新日 2020-02-26 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of the apo form of a ribonuclease H domain of protein DSY1790 from Desulfitobacterium hafniense, Northeast Structural Genomics target DhR1A To be Published
4QAG	Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase 分子名称: (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H 著者 Himmel, D.M, Ho, W.C, Arnold, E. 登録日 2014-05-04 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.712 Å) 主引用文献 Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs. J.Mol.Biol., 426, 2014
2LSN	Solution structure of PFV RNase H domain 分子名称: RNase H 著者 Leo, B, Schweimer, K, Woehrl, B. 登録日 2012-05-03 公開日 2012-10-17 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding. Retrovirology, 9, 2012
2QK9	Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid 分子名称: 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', CITRATE ANION, ... 著者 Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. 登録日 2007-07-10 公開日 2007-11-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007

 

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