7NN9
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8DWB
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6BR5
| N2 neuraminidase in complex with a novel antiviral compound | 分子名称: | (1R)-4-acetamido-1,5-anhydro-3-carbamimidamido-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. | 登録日 | 2017-11-30 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.0379076 Å) | 主引用文献 | A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity. ChemMedChem, 13, 2018
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1B9T
| NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN THE ACTIVE SITE | 分子名称: | 1-(4-CARBOXY-2-GUANIDINOPENTYL)-5,5'-DI(HYDROXYMETHYL)PYRROLIDIN-2-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Finley, J.B, Atigadda, V.R, Duarte, F, Zhao, J.J, Brouillette, W.J, Air, G.M, Luo, M. | 登録日 | 1999-02-15 | 公開日 | 1999-02-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site. J.Mol.Biol., 293, 1999
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1BJI
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7S0I
| CRYSTAL STRUCTURE OF N1 NEURAMINIDASE FROM A/Michigan/45/2015(H1N1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuraminidase, ... | 著者 | Zhu, X, Wilson, I.A. | 登録日 | 2021-08-30 | 公開日 | 2021-12-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.892 Å) | 主引用文献 | A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model. Mbio, 12, 2021
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6U02
| CryoEM-derived model of NA-63 Fab in complex with N9 Shanghai2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab-63 Heavy Chain, Fab-63 Light Chain, ... | 著者 | Ward, A.B, Turner, H.L, Zhu, X. | 登録日 | 2019-08-13 | 公開日 | 2019-12-04 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe, 26, 2019
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6V4O
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6V4N
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7U2T
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7U2Q
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4WA3
| The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NICKEL (II) ION, ... | 著者 | Yang, H, Villanueva, J.M, Gubareva, L.V, Stevens, J. | 登録日 | 2014-08-28 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals. J.Virol., 89, 2015
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4WA4
| The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with oseltamivir carboxylate | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, Neuraminidase, ... | 著者 | Yang, H, Villanueva, J.M, Gubareva, L.V, Stevens, J. | 登録日 | 2014-08-28 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals. J.Virol., 89, 2015
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4WA5
| The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals in complex with zanamivir | 分子名称: | CALCIUM ION, Neuraminidase, ZANAMIVIR, ... | 著者 | Yang, H, Villanueva, J.M, Gubareva, L.V, Stevens, J. | 登録日 | 2014-08-28 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals. J.Virol., 89, 2015
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4WEG
| influenza virus neuraminidase N9 in complex 2,3-difluorosialic acid | 分子名称: | (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, (3R,4R,5R,6R)-5-(acetylamino)-3-fluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4,5,6-tetrahydropyranium-2-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Streltsov, V.A, Pilling, P, Barrett, S, McKimm-Breschkin, J. | 登録日 | 2014-09-10 | 公開日 | 2015-09-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN) Antiviral Res., 123, 2015
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3NN9
| REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ... | 著者 | Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M. | 登録日 | 1991-03-28 | 公開日 | 1992-07-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. J.Mol.Biol., 221, 1991
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3NSS
| The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sites | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | 著者 | Li, Q, Qi, J.X, Zhang, W, Vavricka, C.J, Shi, Y, Gao, G.F. | 登録日 | 2010-07-02 | 公開日 | 2010-09-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site Nat.Struct.Mol.Biol., 17, 2010
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3O9K
| Influenza NA in complex with compound 6 | 分子名称: | 5-acetamido-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-(4-methylphenyl)prop-2-en-1-yl]-D-glycero-D-galacto-non-2-enonic acid, Neuraminidase | 著者 | Russell, R.J, Kerry, P.S. | 登録日 | 2010-08-04 | 公開日 | 2010-12-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4945 Å) | 主引用文献 | Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun, 1, 2010
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3O9J
| Influenza NA in complex with compound 5 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 5-acetamido-2,6-anhydro-3,5-dideoxy-3-prop-2-en-1-yl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ... | 著者 | Russell, R.J, Kerry, P.S. | 登録日 | 2010-08-04 | 公開日 | 2010-12-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.0002 Å) | 主引用文献 | Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun, 1, 2010
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1F8B
| Native Influenza Virus Neuraminidase in Complex with NEU5AC2EN | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | 登録日 | 2000-06-30 | 公開日 | 2001-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase. Protein Sci., 10, 2001
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1F8C
| Native Influenza Neuraminidase in Complex with 4-amino-2-deoxy-2,3-dehydro-N-neuraminic Acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ... | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | 登録日 | 2000-06-30 | 公開日 | 2001-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase. Protein Sci., 10, 2001
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1F8D
| Native Influenza Neuraminidase in Complex with 9-amino-2-deoxy-2,3-dehydro-N-neuraminic Acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-AMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ... | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | 登録日 | 2000-06-30 | 公開日 | 2001-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase. Protein Sci., 10, 2001
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1F8E
| Native Influenza Neuraminidase in Complex with 4,9-diamino-2-deoxy-2,3-dehydro-N-acetyl-neuraminic Acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,9-AMINO-2,4-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, CALCIUM ION, ... | 著者 | Smith, B.J, Colman, P.M, Von Itzstein, M, Danylec, B, Varghese, J.N. | 登録日 | 2000-06-30 | 公開日 | 2001-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Analysis of inhibitor binding in influenza virus neuraminidase. Protein Sci., 10, 2001
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5W2Y
| INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 9-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID | 分子名称: | (2R,3R,4R,5R,6R)-5-acetamido-6-[(1R,2R)-1,2-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic acid, (2~{R},3~{R},4~{R},5~{R})-3-acetamido-2-[(1~{R},2~{R})-1,2-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Streltsov, V.A, Mckimm-Breschkin, J, Barrett, S, Pilling, P, Hader, S, Watt, A.G. | 登録日 | 2017-06-07 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives. J. Med. Chem., 61, 2018
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5W26
| INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 4-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID | 分子名称: | (2R,3R,5R,6R)-5-acetamido-2,3-bis(fluoranyl)-6-[(1R,2R)-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (2~{R},3~{R},5~{R})-3-acetamido-5-fluoranyl-2-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Streltsov, V.A, Mckimm-Breschkin, J, Barrett, S, Pilling, P, Hader, S, Watt, A.G. | 登録日 | 2017-06-05 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives. J. Med. Chem., 61, 2018
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