PDB: 654 件ウェブページステータス検索Chemie searchBIRD

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4UQK	Electron density map of GluA2em in complex with quisqualate and LY451646 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-24 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (16.4 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4X48	Crystal structure of GluR2 ligand-binding core 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ... 著者 Pandit, J. 登録日 2014-12-02 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242). J.Med.Chem., 58, 2015
4WXJ	Drosophila muscle GluRIIB complex with glutamate 分子名称: GLUTAMIC ACID, Glutamate receptor IIB,Glutamate receptor IIB 著者 Dharkar, P, Mayer, M.L. 登録日 2014-11-13 公開日 2015-04-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Proc.Natl.Acad.Sci.USA, 112, 2015
2GFE	Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Mayer, M.L. 登録日 2006-03-21 公開日 2006-08-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate. J.Neurosci., 26, 2006
2I0B	Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2, ... 著者 Mayer, M.L. 登録日 2006-08-10 公開日 2006-11-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Conformational restriction blocks glutamate receptor desensitization. Nat.Struct.Mol.Biol., 13, 2006
2I3W	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 分子名称: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
2I0C	Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2 著者 Mayer, M.L. 登録日 2006-08-10 公開日 2006-11-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Conformational restriction blocks glutamate receptor desensitization. Nat.Struct.Mol.Biol., 13, 2006
2I3V	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
6YK4	Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A 分子名称: (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2020-04-05 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (0.999 Å) 主引用文献 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11, 2020
6YK3	Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.20A 分子名称: (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione, AMMONIUM ION, CHLORIDE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2020-04-05 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11, 2020
6YK2	Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin- 2,4(1H,3H)-dione at resolution 1.60A 分子名称: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2020-04-05 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.612 Å) 主引用文献 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11, 2020
6YK5	Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A 分子名称: (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2020-04-05 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11, 2020
6YK6	Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A 分子名称: (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2020-04-05 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.469 Å) 主引用文献 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci, 11, 2020
6ZYU	Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 分子名称: (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, ACETATE ION, ... 著者 Dorosz, J, Christensen, K.M, Kastrup, J.S. 登録日 2020-08-03 公開日 2021-08-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. Acs Chem Neurosci, 12, 2021
5ZG3	Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137 分子名称: 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ... 著者 Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. 登録日 2018-03-07 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
5ZG1	Crystal structure of the GluA2o LBD in complex with glutamate and Compound-2 分子名称: 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, GLUTAMIC ACID, GLYCEROL, ... 著者 Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. 登録日 2018-03-07 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
5ZG2	Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2 分子名称: 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ACETATE ION, GLYCEROL, ... 著者 Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. 登録日 2018-03-07 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
5ZG0	Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1 分子名称: 9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ... 著者 Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. 登録日 2018-03-07 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44, 2019
1FTJ	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 分子名称: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID, ZINC ION 著者 Armstrong, N, Gouaux, E. 登録日 2000-09-12 公開日 2000-11-01 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTK	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2 著者 Gouaux, E, Armstrong, N. 登録日 2000-09-12 公開日 2000-11-01 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTM	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION 著者 Gouaux, E, Armstrong, N. 登録日 2000-09-12 公開日 2000-11-01 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FW0	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2 著者 Armstrong, N, Gouaux, E. 登録日 2000-09-20 公開日 2000-11-15 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTO	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION 分子名称: GLUTAMATE RECEPTOR SUBUNIT 2 著者 Armstrong, N, Gouaux, E. 登録日 2000-09-12 公開日 2000-11-01 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTL	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION 分子名称: 6,7-DINITROQUINOXALINE-2,3-DIONE, GLUTAMATE RECEPTOR SUBUNIT 2, SULFATE ION 著者 Armstrong, N, Gouaux, E. 登録日 2000-09-12 公開日 2000-11-01 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1GR2	STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, PROTEIN (GLUTAMATE RECEPTOR 2) 著者 Armstrong, N, Sun, Y, Chen, G.Q, Gouaux, E. 登録日 1998-09-17 公開日 1998-12-09 最終更新日 2017-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature, 395, 1998

 

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