PDB: 155 件ウェブページステータス検索Chemie searchBIRD

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5ZNR	Crystal structure of PtSHL in complex with an H3K27me3 peptide 分子名称: 17-mer peptide from Histone H3.2, SHORT LIFE family protein, SULFATE ION, ... 著者 Lv, X, Du, J. 登録日 2018-04-10 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.202 Å) 主引用文献 Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun, 9, 2018
6VIL	Crystal structure of mouse BAHCC1 BAH domain in complex with H3K27me3 分子名称: BAH and coiled-coil domain-containing protein 1, Histone H3.1 著者 Song, J, Lu, J. 登録日 2020-01-13 公開日 2020-09-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.301 Å) 主引用文献 BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat.Genet., 52, 2020
6IP4	Crystal structure of Arabidopsis thaliana JMJ13 catalytic domain in complex with NOG and an H3K27me3 peptide 分子名称: Arabidopsis JMJ13, Histone H3.2, N-OXALYLGLYCINE, ... 著者 Hu, H, Du, J. 登録日 2018-11-02 公開日 2019-04-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun, 10, 2019
7CCE	crystal structure of Arabidopsis AIPP3 BAH domain in complex with an H3K27me3 peptide 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bromo-adjacent homology (BAH) domain-containing protein, Histone H3.2 著者 Yuan, J, Du, J. 登録日 2020-06-17 公開日 2020-12-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nat Commun, 11, 2020
4X3K	Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27me3 peptide 分子名称: Chromobox protein homolog 7, H3K27me3 peptide, NICKEL (II) ION, ... 著者 Ren, C, Zhou, M.M. 登録日 2014-12-01 公開日 2015-03-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
5Z8L	crystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptide 分子名称: Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION 著者 Yang, Z, Du, J. 登録日 2018-01-31 公開日 2018-07-25 最終更新日 2018-09-19 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat. Genet., 50, 2018
5ZNP	Crystal structure of PtSHL in complex with an H3K4me3 peptide 分子名称: 15-mer peptide from Histone H3.2, SHORT LIFE family protein, ZINC ION 著者 Lv, X, Du, J. 登録日 2018-04-10 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun, 9, 2018
6IP0	Crystal structure of Arabidopsis thaliana JMJ13 catalytic domain in complex with AKG 分子名称: 2-OXOGLUTARIC ACID, NICKEL (II) ION, SULFATE ION, ... 著者 Hu, H, Du, J. 登録日 2018-11-01 公開日 2019-04-10 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun, 10, 2019
4X3E	Crystal structure of EED in complex with a trimethylated Jarid2 peptide 分子名称: ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER, Polycomb protein EED 著者 Justin, N, Gamblin, S.J, Margueron, R. 登録日 2014-11-28 公開日 2015-01-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Mol.Cell, 57, 2015
5GSA	EED in complex with an allosteric PRC2 inhibitor 分子名称: Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-08-15 公開日 2017-02-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13, 2017
5WP3	Crystal Structure of EED in complex with EB22 分子名称: EB22, Polycomb protein EED, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2017-08-03 公開日 2017-09-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3AVR	Catalytic fragment of UTX/KDM6A bound with histone H3K27me3 peptide, N-oxyalylglycine, and Ni(II) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Histone H3, ... 著者 Sengoku, T, Yokoyama, S. 登録日 2011-03-07 公開日 2011-10-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Genes Dev., 25, 2011
4V2W	JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35) 分子名称: CHLORIDE ION, GLYCEROL, HISTONE H3.1T, ... 著者 Chowdhury, R, Zafred, D, Schofield, C.J. 登録日 2014-10-15 公開日 2014-11-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
4V2V	JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA 分子名称: CHLORIDE ION, HISTONE H3.1T, LYSINE-SPECIFIC DEMETHYLASE 4A, ... 著者 Chowdhury, R, Madden, S.K, Schofield, C.J. 登録日 2014-10-15 公開日 2014-11-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
4EZH	the crystal structure of KDM6B bound with H3K27me3 peptide 分子名称: Lysine-specific demethylase 6B, N-OXALYLGLYCINE, NICKEL (II) ION, ... 著者 Cheng, Z.J, Patel, D.J. 登録日 2012-05-02 公開日 2012-08-08 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature, 488, 2012
2L1B	Solution NMR structure of the chromobox protein Cbx7 with H3K27me3 分子名称: Chromobox protein homolog 7, Histone H3 著者 Kaustov, L, Lemak, A, Fares, C, Gutmanas, A, Muhandiram, R, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) 登録日 2010-07-27 公開日 2010-08-25 最終更新日 2020-02-05 実験手法 SOLUTION NMR 主引用文献 Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
3JZG	Structure of EED in complex with H3K27me3 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-23 公開日 2009-12-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
6V3N	Crystal structure of CDYL2 in complex with H3K27me3 分子名称: ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, Chromodomain Y-like protein 2, UNKNOWN ATOM OR ION 著者 Qin, S, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) 登録日 2019-11-26 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
5KJH	Crystal structure of an active polycomb repressive complex 2 in the stimulated state 分子名称: Peptide H3K27me3, Putative uncharacterized protein,Zinc finger domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Jiao, L, Liu, X. 登録日 2016-06-20 公開日 2017-04-19 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
5KKL	Structure of ctPRC2 in complex with H3K27me3 and H3K27M 分子名称: ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, S-ADENOSYLMETHIONINE, ... 著者 Jiao, L, Liu, X. 登録日 2016-06-21 公開日 2017-04-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
5U62	Crystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 分子名称: (6S)-6-[(2H-1,3-benzodioxol-4-yl)methyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
5U5T	Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide 分子名称: (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
3AVS	Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 6A, ... 著者 Sengoku, T, Yokoyama, S. 登録日 2011-03-07 公開日 2011-10-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Genes Dev., 25, 2011
5K0M	Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED 分子名称: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED 著者 Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. 登録日 2016-05-17 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13, 2017
2M0O	The solution structure of human PHF1 in complex with H3K36me3 分子名称: H3K36me3 peptide, PHD finger protein 1 著者 Song, J, Patel, D.J. 登録日 2012-10-30 公開日 2013-01-16 最終更新日 2013-02-27 実験手法 SOLUTION NMR 主引用文献 An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting. Mol.Cell, 49, 2013

 

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