変換クエリ:h3k4me3
5J9Q
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
分子名称:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
著者Chen, Z.C., Xu, P.
登録日2016-04-11
公開日2016-10-26
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9T
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
分子名称:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
著者Chen, Z.C., Xu, P.
登録日2016-04-11
公開日2016-10-26
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9U
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
分子名称:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
著者Chen, Z.C., Xu, P.
登録日2016-04-11
公開日2016-10-26
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9W
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
分子名称:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
著者Chen, Z.C., Xu, P.
登録日2016-04-11
公開日2016-10-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5JSG
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML405
分子名称:Spindlin-1, [2-(phenylamino)-1,4-phenylene]bis({4-[2-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}methanone), MAGNESIUM ION, ...
著者Su, X., Li, H.
登録日2016-05-08
公開日2017-05-10
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5JSJ
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631
分子名称:Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ...
著者Su, X., Li, H.
登録日2016-05-08
公開日2017-05-24
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.348 Å)
主引用文献Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5LY1
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JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
分子名称:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
著者King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
登録日2016-09-23
公開日2017-04-12
最終更新日2017-04-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY2
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
分子名称:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
著者CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
登録日2016-09-23
公開日2017-04-12
最終更新日2017-04-19
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
分子名称:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
著者Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
登録日2017-01-10
公開日2018-02-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
5TVR
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JMJD2A IN COMPLEX WITH NI(II) AND ALPHA-KETOGLUTARATE
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
著者Cascella, B., Lee, S.G., Jez, J.M.
登録日2016-11-09
公開日2017-02-01
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.093 Å)
主引用文献The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5TVS
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JMJD2A IN COMPLEX WITH NI(II)
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION
著者Cascella, B., Lee, S.G., Jez, J.M.
登録日2016-11-09
公開日2017-02-01
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.745 Å)
主引用文献The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5VGI
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CRYSTAL STRUCTURE OF KDM4 WITH THE SMALL MOLECULE INHIBITOR QC6352
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
著者Hosfield, D.J.
登録日2017-04-11
公開日2017-09-27
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5VMP
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CRYSTAL STRUCTURE OF HUMAN KDM4 WITH SMALL MOLECULE INHIBITOR QC5714
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
著者Hosfield, D.J.
登録日2017-04-28
公開日2017-09-27
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5WLF
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CRYSTAL STRUCTURE OF THE APO PPS PHD FINGER
分子名称:Protein partner of snf, isoform A, GLYCEROL, ...
著者Klein, B.J., Kutateladze, T.G.
登録日2017-07-26
公開日2017-10-04
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5XMY
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3Q5SER
分子名称:Transcription initiation factor TFIID subunit 3, Histone peptide H3(1-15)K4me3Q5ser, ZINC ION
著者Zhao, S., Zhang, B., Li, H.
登録日2017-05-16
公開日2018-11-28
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser
to be published
6CG1
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 14
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
著者Hosfield, D.J., Nie, Z.
登録日2018-02-19
公開日2018-04-18
最終更新日2018-05-02
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CG2
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 8
分子名称:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
著者Hosfield, D.J., Nie, Z.
登録日2018-02-19
公開日2018-04-18
最終更新日2018-05-02
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018