PDB: 12 resultsInfo pagesStatus searchChemie searchBIRD

---

2LQ7	E2 binding surface on Uba3 beta-grasp domain undergoes a conformational transition Descriptor: NEDD8-activating enzyme E1 catalytic subunit Authors: Elgin, E.S, Peterson, F.C, Volkman, B.F. Deposit date: 2012-02-27 Release date: 2012-07-25 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: E2-binding surface on Uba3 beta-grasp domain undergoes a conformational transition. Proteins, 80, 2012
1YOV	Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8 Descriptor: Amyloid protein-binding protein 1, Ubiquitin-activating enzyme E1C, ZINC ION Authors: Walden, H, Podgorski, M.S, Schulman, B.A. Deposit date: 2005-01-28 Release date: 2005-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8 Nature, 422, 2003
3GZN	Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Sintchak, M.D. Deposit date: 2009-04-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol.Cell, 37, 2010
1TT5	Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Descriptor: Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ... Authors: Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A. Deposit date: 2004-06-21 Release date: 2004-09-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat.Struct.Mol.Biol., 11, 2004
2NVU	Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ... Authors: Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A. Deposit date: 2006-11-13 Release date: 2007-01-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature, 445, 2007
1R4N	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ubiquitin-like protein NEDD8, ZINC ION, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
1R4M	APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex Descriptor: Ubiquitin-like protein NEDD8, ZINC ION, amyloid beta precursor protein-binding protein 1, ... Authors: Walden, H, Podgorski, M.S, Holton, J.M, Schulman, B.A. Deposit date: 2003-10-07 Release date: 2003-12-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol.Cell, 12, 2003
1Y8X	Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1 Descriptor: Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M Authors: Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A. Deposit date: 2004-12-13 Release date: 2005-02-08 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol.Cell, 17, 2005
3DBL	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190wt-NEDD8Ala72Gln) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-06-01 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3DBH	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Ala-NEDD8Ala72Arg) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-05-31 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3DBR	Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Gln-NEDD8Ala72Arg) Descriptor: NEDD8, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 regulatory subunit, ... Authors: Souphron, J, Schulman, B.A. Deposit date: 2008-06-02 Release date: 2008-08-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry, 47, 2008
3FN1	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Descriptor: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F Authors: Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A. Deposit date: 2008-12-22 Release date: 2009-03-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification Mol.Cell, 33, 2009