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6YQQ
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BU of 6yqq by Molmil
ForT-PRPP complex
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, CHLORIDE ION, ForT-PRPP complex, ...
Authors:Naismith, J.H, Gao, S.
Deposit date:2020-04-18
Release date:2020-05-20
Last modified:2021-06-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex.
Chem.Commun.(Camb.), 56, 2020
8AP0
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BU of 8ap0 by Molmil
ForT Mutant T138V
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4-azanyl-1~{H}-pyrazole-3,5-dicarboxylic acid, Beta-ribofuranosylaminobenzene 5'-phosphate synthase, ...
Authors:Li, W, Naismith, J.H.
Deposit date:2022-08-09
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase.
Open Biology, 13, 2023
8AOZ
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BU of 8aoz by Molmil
ForT Mutant L24A
Descriptor: 1,2-ETHANEDIOL, 4-azanyl-3-[(2~{S},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-1~{H}-pyrazole-5-carboxylic acid, Beta-ribofuranosylaminobenzene 5'-phosphate synthase, ...
Authors:Li, W, Naismith, J.H.
Deposit date:2022-08-09
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase.
Open Biology, 13, 2023
6GR2
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BU of 6gr2 by Molmil
Structure of human galactokinase in complex with galactose and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Galactokinase, SULFATE ION, ...
Authors:Bezerra, G.A, Mackinnon, S, Williams, E, Zhang, M, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC)
Deposit date:2018-06-08
Release date:2019-06-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure of human galactokinase in complex with galactose and ADP
To Be Published
6CYZ
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BU of 6cyz by Molmil
Mycobacterial homoserine kinase ThrB in complex with AMPPNP
Descriptor: CHLORIDE ION, Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Li, J, Korotkov, K.V.
Deposit date:2018-04-07
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mycobacterial homoserine kinase ThrB
To Be Published
7OZX
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BU of 7ozx by Molmil
Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone
Descriptor: (azepan-1-yl)(2,6-difluorophenyl)methanone, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, ...
Authors:Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W.
Deposit date:2021-06-29
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone
To Be Published
4RPF
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BU of 4rpf by Molmil
Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715
Descriptor: CITRIC ACID, Homoserine kinase
Authors:Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-10-30
Release date:2014-11-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715
To be Published
2WW4
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BU of 2ww4 by Molmil
a triclinic crystal form of E. coli 4-diphosphocytidyl-2C-methyl-D- erythritol kinase
Descriptor: 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Kalinowska-Tluscik, J, Miallau, L, Gabrielsen, M, Leonard, G.A, McSweeney, S.M, Hunter, W.N.
Deposit date:2009-10-21
Release date:2010-03-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Triclinic Crystal Form of Escherichia Coli 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase and Reassessment of the Quaternary Structure.
Acta Crystallogr.,Sect.F, 66, 2010
4N3O
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BU of 4n3o by Molmil
2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni.
Descriptor: CALCIUM ION, Putative D-glycero-D-manno-heptose 7-phosphate kinase
Authors:Minasov, G, Wawrzak, Z, Gordon, E, Onopriyenko, O, Grimshaw, S, Kwon, K, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-10-07
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni.
TO BE PUBLISHED
5WAT
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BU of 5wat by Molmil
Corynebacterium glutamicum Full length Homoserine kinase
Descriptor: HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ...
Authors:Petit, C, Ronning, D.R.
Deposit date:2017-06-27
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis.
ACS Omega, 3, 2018
4EMD
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BU of 4emd by Molmil
Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to CMP and SO4
Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-04-11
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
5WAS
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BU of 5was by Molmil
Corynebacterium glutamicum Hydrolyzed Homoserine kinase
Descriptor: Homoserine kinase, PHOSPHATE ION
Authors:Petit, C, Ronning, D.R.
Deposit date:2017-06-27
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis.
ACS Omega, 3, 2018
8TFO
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BU of 8tfo by Molmil
Structure of MKvar
Descriptor: (R)-MEVALONATE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Peat, T.S, Newman, J, Esquirol, L, Nebl, T, Scott, C, Vickers, C, Sainsbury, F.
Deposit date:2023-07-11
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii.
Acta Crystallogr D Struct Biol, 80, 2024
8TEB
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BU of 8teb by Molmil
Structure of MKbur
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Peat, T.S, Newman, J, Esquirol, L, Nebl, T, Scott, C, Vickers, C, Sainsbury, F.
Deposit date:2023-07-06
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii.
Acta Crystallogr D Struct Biol, 80, 2024
4HAC
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BU of 4hac by Molmil
Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei
Descriptor: MAGNESIUM ION, Mevalonate kinase
Authors:Zhuang, N, Lee, K.H.
Deposit date:2012-09-26
Release date:2012-12-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei.
Acta Crystallogr.,Sect.F, 68, 2012
6MDE
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BU of 6mde by Molmil
Mevalonate kinase from Methanosarcina mazei with mevalonate bound
Descriptor: (R)-MEVALONATE, GLYCEROL, Mevalonate kinase, ...
Authors:Miller, B.R, Kung, Y.
Deposit date:2018-09-04
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into substrate and product binding in an archaeal mevalonate kinase.
PLoS ONE, 13, 2018
6MDF
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BU of 6mdf by Molmil
Mevalonate kinase from Methanosarcina mazei with 5-phosphomevalonate bound
Descriptor: (3R)-3-HYDROXY-3-METHYL-5-(PHOSPHONOOXY)PENTANOIC ACID, GLYCEROL, Mevalonate kinase
Authors:Miller, B.R, Kung, Y.
Deposit date:2018-09-04
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural insight into substrate and product binding in an archaeal mevalonate kinase.
PLoS ONE, 13, 2018
2HFU
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BU of 2hfu by Molmil
Crystal structure of L. major mevalonate kinase in complex with R-mevalonate
Descriptor: (R)-MEVALONATE, Mevalonate kinase, putative
Authors:Sgraja, T, Hunter, W.N.
Deposit date:2006-06-26
Release date:2007-04-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase.
Bmc Struct.Biol., 7, 2007
2HFS
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BU of 2hfs by Molmil
Crystal structure of L. major mevalonate kinase
Descriptor: Mevalonate kinase, putative
Authors:Sgraja, T, Hunter, W.N.
Deposit date:2006-06-26
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase.
Bmc Struct.Biol., 7, 2007
5YYS
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BU of 5yys by Molmil
Cryo-EM structure of L-fucokinase, GDP-fucose pyrophosphorylase (FKP)in Bacteroides fragilis
Descriptor: L-fucokinase, L-fucose-1-P guanylyltransferase
Authors:Wang, J, Hu, H, Liu, Y, Zhou, Q, Wu, P, Yan, N, Wang, H.W, Wu, J.W, Sun, L.
Deposit date:2017-12-11
Release date:2018-12-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis.
Protein Cell, 10, 2019
6ZGZ
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BU of 6zgz by Molmil
Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide
Descriptor: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, beta-D-galactopyranose, ...
Authors:Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W.
Deposit date:2020-06-20
Release date:2020-07-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
Acs Chem.Biol., 16, 2021
3V2U
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BU of 3v2u by Molmil
Crystal structure of the yeast GAL regulon complex of the repressor, Gal80p, and the transducer, Gal3p, with galactose and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Galactose/lactose metabolism regulatory protein GAL80, ...
Authors:Lavy, T, Kumar, P.R, He, H, Joshua-Tor, L.
Deposit date:2011-12-12
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.
Genes Dev., 26, 2012
1FWK
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BU of 1fwk by Molmil
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HOMOSERINE KINASE, MAGNESIUM ION
Authors:Zhou, T, Daugherty, M, Grishin, N.V, Osterman, A.L, Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
1FWL
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BU of 1fwl by Molmil
CRYSTAL STRUCTURE OF HOMOSERINE KINASE
Descriptor: HOMOSERINE KINASE
Authors:Zhou, T, Daugherty, M, Grishin, N.V, Osterman, A.L, Zhang, H.
Deposit date:2000-09-22
Release date:2000-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure Fold.Des., 8, 2000
3V5R
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BU of 3v5r by Molmil
Crystal structure of the unliganded form of Gal3p
Descriptor: Protein GAL3, SULFATE ION
Authors:Lavy, T, Kumar, P.R, He, H, Joshua-Tor, L.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.
Genes Dev., 26, 2012

 

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