6I9B
| NMR structure of the La module from human LARP4A | Descriptor: | La-related protein 4 | Authors: | Conte, M.R, Martino, L, Atkinson, R.A, Kelly, G, Cruz-Gallardo, I, De Tito, S, Trotta, R. | Deposit date: | 2018-11-22 | Release date: | 2019-03-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA. Nucleic Acids Res., 47, 2019
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2CQK
| Solution structure of the La domain of c-Mpl binding protein | Descriptor: | C-Mpl binding protein | Authors: | Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-20 | Release date: | 2005-11-20 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of the La domain of c-Mpl binding protein To be Published
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1S29
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1S7A
| NMR structure of the La motif of human La protein | Descriptor: | Lupus La protein | Authors: | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | Deposit date: | 2004-01-29 | Release date: | 2004-04-06 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat.Struct.Mol.Biol., 11, 2004
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2M5W
| NMR Solution Structure of the La motif (N-terminal Domain, NTD) of Dictyostelium discoideum La protein | Descriptor: | Lupus La protein | Authors: | Vourtsis, D.J, Chasapis, C.T, Apostolidi, M, Stathopoulos, C, Bentrop, D, Spyroulias, G.A. | Deposit date: | 2013-03-11 | Release date: | 2014-03-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of the La motif (N-terminal Domain, NTD) of Dictyostelium discoideum La protein To be Published
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2MTF
| Solution structure of the La motif of human LARP6 | Descriptor: | La-related protein 6 | Authors: | Martino, L, Salisbury, N.JH, Atkinson, A.R, Kelly, G, Conte, M.R. | Deposit date: | 2014-08-18 | Release date: | 2014-12-24 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Nucleic Acids Res., 43, 2015
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7SOW
| LaM domain of human LARP1 in complex with UUUUUU | Descriptor: | 1,2-ETHANEDIOL, Isoform 2 of La-related protein 1, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | Authors: | Kozlov, G, Gehring, K. | Deposit date: | 2021-11-01 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of 3'-end RNA recognition by LARP1 To Be Published
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8EY7
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8EY8
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8EY6
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4WKR
| LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332) | Descriptor: | 7SK GGHP4 (300-332), La-related protein 7 | Authors: | Uchikawa, E, Natchiar, K.S, Han, X, Proux, F, Roblin, P, Zhang, E, Durand, A, Klaholz, B.P, Dock-Bregeon, A.-C. | Deposit date: | 2014-10-03 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. Nucleic Acids Res., 43, 2015
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6D6V
| CryoEM structure of Tetrahymena telomerase with telomeric DNA at 4.8 Angstrom resolution | Descriptor: | DNA (5'-D(P*GP*TP*TP*GP*GP*GP*GP*TP*TP*GP*GP*GP*GP*TP*TP*GP*GP*GP*G)-3'), RNA (159-MER), Telomerase associated protein p65, ... | Authors: | Jiang, J, Wang, Y, Susac, L, Chan, H, Basu, R, Zhou, Z.H, Feigon, J. | Deposit date: | 2018-04-22 | Release date: | 2018-05-30 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structure of Telomerase with Telomeric DNA. Cell, 173, 2018
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2VON
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU | Descriptor: | 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3', LUPUS LA PROTEIN | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | Deposit date: | 2008-02-19 | Release date: | 2008-05-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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7UY6
| Tetrahymena telomerase at 2.9 Angstrom resolution | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
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7UY5
| Tetrahymena telomerase with CST | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J. | Deposit date: | 2022-05-06 | Release date: | 2022-07-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase. Nature, 608, 2022
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7LMA
| Tetrahymena telomerase T3D2 structure at 3.3 Angstrom | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-02-05 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of telomerase at several steps of telomere repeat synthesis. Nature, 593, 2021
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7LMB
| Tetrahymena telomerase T5D5 structure at 3.8 Angstrom | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-02-05 | Release date: | 2021-05-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of telomerase at several steps of telomere repeat synthesis. Nature, 593, 2021
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1YTY
| Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen | Descriptor: | 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein | Authors: | Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J. | Deposit date: | 2005-02-11 | Release date: | 2006-01-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen. Mol.Cell, 21, 2006
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1ZH5
| Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen | Descriptor: | 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein, SULFATE ION | Authors: | Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J. | Deposit date: | 2005-04-22 | Release date: | 2006-01-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen. Mol.Cell, 21, 2006
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2VOO
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | Deposit date: | 2008-02-19 | Release date: | 2008-05-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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2VOD
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU | Descriptor: | 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | Deposit date: | 2008-02-15 | Release date: | 2008-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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2VOP
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU | Descriptor: | 5'-R(*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN, SULFATE ION | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | Deposit date: | 2008-02-19 | Release date: | 2008-05-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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7SLP
| Cryo-EM structure of 7SK core RNP with linear RNA | Descriptor: | 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Linear 7SK RNA, ... | Authors: | Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-10-24 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
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7SLQ
| Cryo-EM structure of 7SK core RNP with circular RNA | Descriptor: | 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Minimal circular 7SK RNA, ... | Authors: | Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. | Deposit date: | 2021-10-24 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
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8GAP
| Structure of LARP7 protein p65-telomerase RNA complex in telomerase | Descriptor: | Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ... | Authors: | Wang, Y, He, Y, Wang, Y, Yang, Y, Singh, M, Eichhorn, C.D, Zhou, Z.H, Feigon, J. | Deposit date: | 2023-02-23 | Release date: | 2023-06-28 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. J.Mol.Biol., 435, 2023
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