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7P3F
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BU of 7p3f by Molmil
Streptomyces coelicolor dATP/ATP-loaded NrdR in complex with its cognate DNA
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-07
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
7P3Q
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BU of 7p3q by Molmil
Streptomyces coelicolor dATP/ATP-loaded NrdR octamer
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ...
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-08
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
7P37
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BU of 7p37 by Molmil
Streptomyces coelicolor ATP-loaded NrdR
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Transcriptional repressor NrdR, ZINC ION
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2021-07-07
Release date:2022-05-11
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Nat Commun, 13, 2022
8P28
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BU of 8p28 by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its tetrameric, dATP-bound state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION
Authors:Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-15
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
To Be Published
8P27
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BU of 8p27 by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, dATP-bound state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION
Authors:Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-15
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
Elife, 2023
8P23
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BU of 8p23 by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, ATP/CTP-bound state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-14
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
Elife, 2023
8P2C
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BU of 8p2c by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its tetrameric state produced in the presence of dATP and CTP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION
Authors:Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-15
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
eLife, 2023
8P2S
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BU of 8p2s by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, ATP/dTTP/GTP-bound state
Descriptor: Anaerobic ribonucleoside-triphosphate reductase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bimai, O, Banerjee, I, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-16
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
eLife, 2023
8P39
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BU of 8p39 by Molmil
Cryo-EM structure of the anaerobic ribonucleotide reductase from Prevotella copri in its dimeric, dGTP/ATP-bound state
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, ...
Authors:Bimai, O, Banerjee, I, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-17
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
To be published
8P2D
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BU of 8p2d by Molmil
Cryo-EM structure of the dimeric form of the anaerobic ribonucleotide reductase from Prevotella copri produced in the presence of dATP and CTP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Anaerobic ribonucleoside-triphosphate reductase, MAGNESIUM ION
Authors:Banerjee, I, Bimai, O, Sjoberg, B.M, Logan, D.T.
Deposit date:2023-05-15
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
eLife, 2023
4ERM
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BU of 4erm by Molmil
Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zimanyi, C.M, Drennan, C.L.
Deposit date:2012-04-20
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.
Structure, 20, 2012
4X3V
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BU of 4x3v by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to inhibitor
Descriptor: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE
Authors:Dealwis, C.G, Ahmad, M.F, Alam, I.
Deposit date:2014-12-01
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58, 2015
4R1R
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BU of 4r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI
Descriptor: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ...
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-07-22
Release date:1998-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
5TUS
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BU of 5tus by Molmil
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
Descriptor: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
Authors:Mohammed, F.A, Alam, I, Dealwis, C.G.
Deposit date:2016-11-07
Release date:2017-08-02
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5IM3
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BU of 5im3 by Molmil
Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase
Authors:Johansson, R, Logan, D.T.
Deposit date:2016-03-05
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.
Structure, 24, 2016
7AGJ
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BU of 7agj by Molmil
Ribonucleotide Reductase R1 protein from Aquifex aeolicus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Rehling, D, Scaletti, E.R, Stenmark, P.
Deposit date:2020-09-22
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
6R1R
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BU of 6r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
7MDI
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BU of 7mdi by Molmil
Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Levitz, T.S, Drennan, C.L, Brignole, E.J.
Deposit date:2021-04-05
Release date:2022-01-05
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.
J.Struct.Biol., 214, 2021
6W4X
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BU of 6w4x by Molmil
Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ...
Authors:Kang, G, Taguchi, A, Stubbe, J, Drennan, C.
Deposit date:2020-03-11
Release date:2020-04-08
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.
Science, 368, 2020
6AUI
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BU of 6aui by Molmil
Human ribonucleotide reductase large subunit (alpha) with dATP and CDP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A.
Deposit date:2017-09-01
Release date:2018-04-18
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
Elife, 7, 2018
4ERP
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BU of 4erp by Molmil
Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 subunit alpha, ...
Authors:Zimanyi, C.M, Drennan, C.L.
Deposit date:2012-04-20
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.45 Å)
Cite:Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.
Structure, 20, 2012
2R1R
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BU of 2r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-07-21
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
5OLK
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BU of 5olk by Molmil
Crystal structure of the ATP-cone-containing NrdB from Leeuwenhoekiella blandensis
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ...
Authors:Hasan, M, Grinberg, A.R, Sjoberg, B.M, Logan, D.T.
Deposit date:2017-07-28
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
Elife, 7, 2018
5R1R
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BU of 5r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
1R1R
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BU of 1r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-07-15
Release date:1998-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997

 

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