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5NNU
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BU of 5nnu by Molmil
KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping
Descriptor: DNA, DNA containing an abasic site, Uracil-DNA glycosylase
Authors:Earl, C, Bagneris, C, Barrett, T, Savva, R.
Deposit date:2017-04-10
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
1AKZ
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BU of 1akz by Molmil
HUMAN URACIL-DNA GLYCOSYLASE
Descriptor: URACIL-DNA GLYCOSYLASE
Authors:Tainer, J.A, Mol, C.D.
Deposit date:1997-05-27
Release date:1997-08-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
Embo J., 17, 1998
5T2W
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BU of 5t2w by Molmil
Structure of thymine DNA glycosylase bound to substrate analog 2'-F-5-formyl-dC
Descriptor: DNA (27-MER), DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2016-08-24
Release date:2016-11-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.
Biochemistry, 55, 2016
4SKN
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BU of 4skn by Molmil
A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA
Descriptor: DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ...
Authors:Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A.
Deposit date:1999-02-20
Release date:1999-02-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature, 384, 1996
3IKB
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BU of 3ikb by Molmil
The structure of a conserved protein from Streptococcus mutans UA159.
Descriptor: CITRATE ANION, uncharacterized conserved protein
Authors:Tan, K, Hatzos, C, Buck, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-08-05
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:The structure of a conserved protein from Streptococcus mutans UA159.
To be Published
4FNC
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BU of 4fnc by Molmil
Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
Descriptor: 5-HYDROXYMETHYL URACIL, DNA (28-MER), DNA (29-MER), ...
Authors:Hashimoto, H, Hong, S, Bhagwat, A.S, Zhang, X, Cheng, X.
Deposit date:2012-06-19
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
4JGC
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BU of 4jgc by Molmil
Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)
Descriptor: 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ...
Authors:Hashimoto, H, Zhang, X, Cheng, X.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.582 Å)
Cite:Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.
Dna Repair, 12, 2013
3A7N
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BU of 3a7n by Molmil
Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis
Descriptor: CITRATE ANION, Uracil-DNA glycosylase
Authors:Kaushal, P.S, Talawar, R.K, Varshney, U, Vijayan, M.
Deposit date:2009-09-29
Release date:2010-08-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands
Acta Crystallogr.,Sect.F, 66, 2010
5JXY
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BU of 5jxy by Molmil
Enzyme-substrate complex of TDG catalytic domain bound to a G/U analog
Descriptor: DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
Authors:Pidugu, L.S, Pozharski, E, Malik, S.S, Drohat, A.C.
Deposit date:2016-05-13
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.
Nucleic Acids Res., 44, 2016
3ZOR
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BU of 3zor by Molmil
Structure of BsUDG
Descriptor: URACIL-DNA GLYCOSYLASE
Authors:Banos-Sanz, J.I, Mojardin, L, Sanz-Aparicio, J, Gonzalez, B, Salas, M.
Deposit date:2013-02-22
Release date:2013-05-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal Structure and Functional Insights Into Uracil-DNA Glycosylase Inhibition by Phage Phi29 DNA Mimic Protein P56
Nucleic Acids Res., 41, 2013
4UQM
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BU of 4uqm by Molmil
Crystal structure determination of uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans in complex with DNA - new insights into the role of the Leucine-loop for damage recognition and repair
Descriptor: 5'-D(*CP*CP*TP*AP*TP*CP*CP*AP*AAB*GP*TP*CP*TP*CP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*GP*AP*CP*AP*TP*GP*GP*AP*CP*AP*G)-3', CHLORIDE ION, ...
Authors:Pedersen, H.L, Johnson, K.A, McVey, C.E, Leiros, I, Moe, E.
Deposit date:2014-06-24
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4WS6
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BU of 4ws6 by Molmil
Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-aminouracil, Form I
Descriptor: 1,2-ETHANEDIOL, 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, CHLORIDE ION, ...
Authors:Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M.
Deposit date:2014-10-25
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
Acta Crystallogr.,Sect.D, 71, 2015
4WPL
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BU of 4wpl by Molmil
Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with uracil, Form I
Descriptor: ACETATE ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M.
Deposit date:2014-10-20
Release date:2015-07-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
Acta Crystallogr.,Sect.D, 71, 2015
5NNH
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BU of 5nnh by Molmil
KSHV uracil-DNA glycosylase, apo form
Descriptor: SULFATE ION, Uracil-DNA glycosylase
Authors:Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R.
Deposit date:2017-04-09
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
5NN7
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BU of 5nn7 by Molmil
KSHV uracil-DNA glycosylase, apo form
Descriptor: Uracil-DNA glycosylase
Authors:Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R.
Deposit date:2017-04-08
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
4EUG
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BU of 4eug by Molmil
Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex
Descriptor: PROTEIN (GLYCOSYLASE)
Authors:Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.
Biochemistry, 38, 1999
6U17
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BU of 6u17 by Molmil
Human thymine DNA glycosylase bound to DNA with 2'-F-5-carboxyl-dC substrate analog
Descriptor: ACETATE ION, DNA (28-MER), DNA (30-MER), ...
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2019-08-15
Release date:2019-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
J.Am.Chem.Soc., 141, 2019
6U16
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BU of 6u16 by Molmil
Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate
Descriptor: 1,2-ETHANEDIOL, DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2019-08-15
Release date:2019-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
J.Am.Chem.Soc., 141, 2019
6U15
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BU of 6u15 by Molmil
Human thymine DNA glycosylase N140A mutant bound to DNA with 2'-F-5-carboxyl-dC substrate analog
Descriptor: DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
Authors:Pidugu, L.S, Pozharski, E, Drohat, A.C.
Deposit date:2019-08-15
Release date:2019-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
J.Am.Chem.Soc., 141, 2019
6VBA
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BU of 6vba by Molmil
Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA)
Descriptor: 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase
Authors:Moiani, D, Arvai, A.S, Tainer, J.A.
Deposit date:2019-12-18
Release date:2021-03-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog.Biophys.Mol.Biol., 163, 2021
2EUG
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BU of 2eug by Molmil
CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor: PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G, Tordova, M, Jagadeesh, J, Drohat, A.C, Stivers, J.T, Gilliland, G.L.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
1EMH
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BU of 1emh by Molmil
CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA
Descriptor: DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*(P2U)P*AP*TP*CP*TP*T)-3'), URACIL-DNA GLYCOSYLASE
Authors:Parikh, S.S, Slupphaug, G, Krokan, H.E, Blackburn, G.M, Tainer, J.A.
Deposit date:2000-03-16
Release date:2000-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA, 97, 2000
5CYS
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BU of 5cys by Molmil
Structure of the enzyme-product complex resulting from TDG action on a GcaC mismatch
Descriptor: ACETIC ACID, DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase
Authors:Pozharski, E, Malik, S.S, Drohat, A.C.
Deposit date:2015-07-30
Release date:2015-09-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Characterizing the enzyme-product complexes of thymine DNA glycosylase using crystallography and NMR
Nucleic Acids Res., 2015
1EUG
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BU of 1eug by Molmil
CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor: PROTEIN (GLYCOSYLASE)
Authors:Xiao, G, Tordova, M, Jagadeesh, J, Drohat, A.C, Stivers, J.T, Gilliland, G.L.
Deposit date:1998-10-12
Release date:1999-10-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
1EMJ
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BU of 1emj by Molmil
URACIL-DNA GLYCOSYLASE BOUND TO DNA CONTAINING A 4'-THIO-2'DEOXYURIDINE ANALOG PRODUCT
Descriptor: DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*(ASU)P*AP*TP*CP*TP*T)-3'), URACIL, ...
Authors:Parikh, S.S, Walcher, G, Jones, G.D, Slupphaug, G, Krokan, H.E, Blackburn, G.M, Tainer, J.A.
Deposit date:2000-03-16
Release date:2000-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA, 97, 2000

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