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2MI1	Somatostatin-14 solution structure in 5% D-mannitol Descriptor: Somatostatin-14 Authors: Anoop, A, Ranganathan, S, Pratihar, S. Deposit date: 2013-12-08 Release date: 2014-05-07 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: relevance to its storage and secretion. J.Biol.Chem., 289, 2014
7S8L	CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14 Descriptor: Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. Deposit date: 2021-09-18 Release date: 2021-11-17 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (2.45 Å) Cite: Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7S8M	CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 Descriptor: Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. Deposit date: 2021-09-18 Release date: 2021-11-17 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7T10	CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ... Authors: Robertson, M.J, Skinotis, G. Deposit date: 2021-11-30 Release date: 2022-03-09 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Plasticity in ligand recognition at somatostatin receptors. Nat.Struct.Mol.Biol., 29, 2022
7VDL	Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14 Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Li, Y, Yang, F. Deposit date: 2021-09-07 Release date: 2021-12-01 Last modified: 2022-07-20 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
7VV4	Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local Descriptor: CHOLESTEROL, Mas-related G-protein coupled receptor member X2, circular cortistatin-14 Authors: Li, Y, Yang, F. Deposit date: 2021-11-04 Release date: 2021-12-01 Last modified: 2022-07-20 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
7WIC	Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. Deposit date: 2022-01-03 Release date: 2022-06-01 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
7WJ5	Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity Descriptor: Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T. Deposit date: 2022-01-05 Release date: 2022-07-13 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. Elife, 11, 2022
7XMR	CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. Deposit date: 2022-04-26 Release date: 2022-08-03 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
7XMS	CryoEM structure of somatostatin receptor 4 (SSTR4) in complex with Gi1 and its endogeneous ligand SST-14 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q. Deposit date: 2022-04-26 Release date: 2022-08-03 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Res., 32, 2022
7XAT	Structure of somatostatin receptor 2 bound with SST14. Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. Deposit date: 2022-03-19 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
7Y27	Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex Descriptor: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Chen, S, Zheng, S. Deposit date: 2022-06-09 Release date: 2022-10-19 Last modified: 2023-02-15 Method: ELECTRON MICROSCOPY (3.48 Å) Cite: Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023