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8PAY
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BU of 8pay by Molmil
Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 2.
Descriptor: ACE-GLN-ALC-GLC-LEU-PHE, Beta sliding clamp, GLYCEROL, ...
Authors:Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, wagner, J, Guichard, G.
Deposit date:2023-06-08
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Jacs Au, 4, 2024
8PAT
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BU of 8pat by Molmil
Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 3.
Descriptor: ACE-GLN-ALC-GLX-LEU-PHE, Beta sliding clamp
Authors:Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, Guichard, G.
Deposit date:2023-06-08
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Jacs Au, 4, 2024
4K3L
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BU of 4k3l by Molmil
E. coli sliding clamp in complex with AcLF dipeptide
Descriptor: 1,2-ETHANEDIOL, ACETYL GROUP, CALCIUM ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-04-10
Release date:2013-05-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp
J.Med.Chem., 56, 2013
4TR6
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BU of 4tr6 by Molmil
Crystal structure of DNA polymerase sliding clamp from Bacillus subtilis
Descriptor: DNA polymerase III subunit beta, SODIUM ION
Authors:Burnouf, D, Olieric, V, Ennifar, E, Wolff, P.
Deposit date:2014-06-14
Release date:2014-09-10
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
8CIY
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BU of 8ciy by Molmil
DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin.
Descriptor: ACETATE ION, Beta sliding clamp, CALCIUM ION, ...
Authors:Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R.
Deposit date:2023-02-11
Release date:2023-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
7AZ8
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BU of 7az8 by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 43 bound
Descriptor: Beta sliding clamp, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
Deposit date:2020-11-16
Release date:2021-12-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
4MJR
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BU of 4mjr by Molmil
E. coli sliding clamp in complex with (S)-Carprofen
Descriptor: (2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid, CALCIUM ION, CHLORIDE ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-09-04
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.
Chem.Biol., 21, 2014
6FVM
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BU of 6fvm by Molmil
Mutant DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide
Descriptor: Beta sliding clamp, CALCIUM ION, GLYCEROL, ...
Authors:Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D.
Deposit date:2018-03-04
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.631 Å)
Cite:Peptide Interactions on Bacterial Sliding Clamps.
Acs Infect Dis., 2019
3D1G
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BU of 3d1g by Molmil
Structure of a small molecule inhibitor bound to a DNA sliding clamp
Descriptor: DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
Authors:Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M.
Deposit date:2008-05-05
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1OK7
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BU of 1ok7 by Molmil
A Conserved protein binding-site on Bacterial Sliding Clamps
Descriptor: DNA POLYMERASE III, DNA POLYMERASE IV
Authors:Burnouf, D.Y, Olieric, V, Wagner, J, Fujii, S, Reinbolt, J, Fuchs, R.P.P, Dumas, P.
Deposit date:2003-07-18
Release date:2004-07-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and Biochemical Analysis of Sliding Clamp/Ligand Interactions Suggest a Competition between Replicative and Translesion DNA Polymerases
J.Mol.Biol., 335, 2004
7AZ7
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BU of 7az7 by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 37 bound
Descriptor: Beta sliding clamp, FORMIC ACID, PENTAETHYLENE GLYCOL, ...
Authors:Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
Deposit date:2020-11-16
Release date:2021-12-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
4N96
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BU of 4n96 by Molmil
E. coli sliding clamp in complex with 6-nitroindazole
Descriptor: 6-NITROINDAZOLE, CALCIUM ION, CHLORIDE ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-10-19
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
4N98
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BU of 4n98 by Molmil
E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid
Descriptor: 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-10-19
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
5W7Z
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BU of 5w7z by Molmil
Crystal structure of DNA polymerase III subunit beta from Rickettsia conorii
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, DNA polymerase III subunit beta
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-06-21
Release date:2017-07-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of DNA polymerase III subunit beta from Rickettsia conorii
to be published
4MJQ
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BU of 4mjq by Molmil
E. coli sliding clamp in complex with Bromfenac
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-09-04
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.
Chem.Biol., 21, 2014
4N94
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BU of 4n94 by Molmil
E. coli sliding clamp in complex with 3,4-difluorobenzamide
Descriptor: 1,2-ETHANEDIOL, 3,4-difluorobenzamide, CALCIUM ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-10-19
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
4K3S
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BU of 4k3s by Molmil
E. coli sliding clamp in P1 crystal space group
Descriptor: CALCIUM ION, DNA polymerase III subunit beta, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-04-11
Release date:2013-05-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp
J.Med.Chem., 56, 2013
6PTR
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BU of 6ptr by Molmil
Crystal structure of a DnaN sliding clamp (DNA polymerase III subunit beta) from Bartonella birtlesii bound to griselimycin
Descriptor: 1,2-ETHANEDIOL, ACE-MVA-MP8-NZC-LEU-MP8-LEU-MVA-PRO-MLU-GLY, Beta sliding clamp, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-07-16
Release date:2019-08-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a DnaN sliding clamp (DNA polymerase III subunit beta) from Bartonella birtlesii bound to griselimycin
To Be Published
8CIX
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BU of 8cix by Molmil
DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Griselimycin.
Descriptor: ACETATE ION, Beta sliding clamp, CALCIUM ION, ...
Authors:Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R.
Deposit date:2023-02-11
Release date:2023-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
7AZC
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BU of 7azc by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 22 bound
Descriptor: Beta sliding clamp, GLYCEROL, Peptide 22
Authors:Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
Deposit date:2020-11-16
Release date:2021-12-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
3F1V
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BU of 3f1v by Molmil
E. coli Beta Sliding Clamp, 148-153 Ala Mutant
Descriptor: CALCIUM ION, CHLORIDE ION, DNA polymerase III subunit beta
Authors:Cody, V.
Deposit date:2008-10-28
Release date:2009-09-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.
J.Mol.Biol., 387, 2009
4TR8
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BU of 4tr8 by Molmil
Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa
Descriptor: DNA polymerase III subunit beta, SODIUM ION
Authors:Olieric, V, Burnouf, D, Ennifar, E, Wolff, P.
Deposit date:2014-06-15
Release date:2014-09-10
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
4N95
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BU of 4n95 by Molmil
E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione
Descriptor: 5-chloro-1H-indole-2,3-dione, CALCIUM ION, CHLORIDE ION, ...
Authors:Yin, Z, Oakley, A.J.
Deposit date:2013-10-19
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
7AZE
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BU of 7aze by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound
Descriptor: Beta sliding clamp, GLYCEROL, MALONATE ION, ...
Authors:Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
Deposit date:2020-11-16
Release date:2021-12-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
1MMI
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BU of 1mmi by Molmil
E. COLI DNA POLYMERASE BETA SUBUNIT
Descriptor: DNA polymerase III, beta chain
Authors:Oakley, A.J, Prosselkov, P, Wijffels, G, Beck, J.L, Wilce, M.C.J, Dixon, N.E.
Deposit date:2002-09-04
Release date:2003-09-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III.
Acta Crystallogr.,Sect.D, 59, 2003

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