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7KFN
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BU of 7kfn by Molmil
Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base
Descriptor: Double-stranded RNA-specific editase 1, Gli1 1W5 23mer RNA, Gli1 8AZ 23mer RNA, ...
Authors:Wilcox, X.E, Fisher, A.J, Beal, P.A.
Deposit date:2020-10-14
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.
J.Am.Chem.Soc., 143, 2021
6D06
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BU of 6d06 by Molmil
Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*NP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2018-04-10
Release date:2019-02-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Bump-Hole Approach for Directed RNA Editing.
Cell Chem Biol, 26, 2019
1ZY7
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BU of 1zy7 by Molmil
Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)
Descriptor: INOSITOL HEXAKISPHOSPHATE, RNA-specific adenosine deaminase B1, isoform DRADA2a, ...
Authors:Macbeth, M.R, Schubert, H.L, Vandemark, A.P, Lingam, A.T, Hill, C.P, Bass, B.L.
Deposit date:2005-06-09
Release date:2005-09-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
Science, 309, 2005
5HP2
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BU of 5hp2 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AU basepair at reaction site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*UP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2016-01-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.983 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5HP3
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BU of 5hp3 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2016-01-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.091 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5ED2
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BU of 5ed2 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ...
Authors:Matthews, M.M, Fisher, A.J.
Deposit date:2015-10-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5ED1
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BU of 5ed1 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from S. cerevisiae BDF2 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2015-10-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
6VFF
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BU of 6vff by Molmil
Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Thuy-boun, A.S, Fisher, A.J, Beal, P.A.
Deposit date:2020-01-03
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Nucleic Acids Res., 48, 2020
8E4X
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BU of 8e4x by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Fisher, A.J, Mendoza, H.G.
Deposit date:2022-08-19
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Nucleic Acids Res., 50, 2022
8E0F
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BU of 8e0f by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Wilcox, X.E, Fisher, A.J, Beal, P.A.
Deposit date:2022-08-09
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Nucleic Acids Res., 50, 2022

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PDB entries from 2024-03-27

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