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8XQK
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BU of 8xqk by Molmil
The Crystal Structure of Apaf from Biortus.
Descriptor: Apoptotic protease-activating factor 1, PHOSPHATE ION
Authors:Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C.
Deposit date:2024-01-05
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Crystal Structure of Apaf from Biortus.
To Be Published
8JOL
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BU of 8jol by Molmil
cryo-EM structure of the CED-4/CED-3 holoenzyme
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 3, Cell death protein 4, ...
Authors:Li, Y, Tian, L, Zhang, Y, Shi, Y.
Deposit date:2023-06-07
Release date:2023-06-28
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8JO0
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BU of 8jo0 by Molmil
The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Li, Y, Shi, Y.
Deposit date:2023-06-06
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8JNS
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BU of 8jns by Molmil
cryo-EM structure of a CED-4 hexamer
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION
Authors:Li, Y, Shi, Y.
Deposit date:2023-06-06
Release date:2023-06-28
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into CED-3 activation.
Life Sci Alliance, 6, 2023
8FW9
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BU of 8fw9 by Molmil
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Descriptor: NLR family CARD domain-containing protein 4
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-20
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (4.46 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
8FW2
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BU of 8fw2 by Molmil
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
Descriptor: NLR family CARD domain-containing protein 4
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-20
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
8FVU
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BU of 8fvu by Molmil
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1, Lethal factor,Type III secretion system protein, ...
Authors:Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S.
Deposit date:2023-01-19
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing.
Nat.Struct.Mol.Biol., 31, 2024
8CZO
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BU of 8czo by Molmil
Cryo-EM structure of BCL10 CARD - MALT1 DD filament
Descriptor: B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:David, L, Wu, H.
Deposit date:2022-05-25
Release date:2022-06-22
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
8CZD
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BU of 8czd by Molmil
Cryo-EM structure of BCL10 R58Q filament
Descriptor: B-cell lymphoma/leukemia 10
Authors:David, L, Wu, H.
Deposit date:2022-05-24
Release date:2022-06-22
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer Discov, 12, 2022
7NIQ
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BU of 7niq by Molmil
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3'), ...
Authors:Yu, Q, Modis, Y.
Deposit date:2021-02-13
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
7NIC
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BU of 7nic by Molmil
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), ...
Authors:Yu, Q, Modis, Y.
Deposit date:2021-02-11
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
7NGA
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BU of 7nga by Molmil
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*G)-3'), ...
Authors:Yu, Q, Modis, Y.
Deposit date:2021-02-08
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
7KEU
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BU of 7keu by Molmil
Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
Descriptor: Apoptosis-associated speck-like protein containing a CARD, Caspase-1
Authors:Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H.
Deposit date:2020-10-12
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
7JN7
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BU of 7jn7 by Molmil
Human DPP9-CARD8 complex
Descriptor: Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9, [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid
Authors:Sharif, H, Hollingsworth, L.R.
Deposit date:2020-08-04
Release date:2021-05-19
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
7JKQ
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BU of 7jkq by Molmil
Human DPP9-CARD8 complex
Descriptor: Caspase recruitment domain-containing protein 8, Dipeptidyl peptidase 9
Authors:Sharif, H, Hollingsworth, L.R.
Deposit date:2020-07-28
Release date:2021-05-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
Immunity, 54, 2021
7DNJ
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BU of 7dnj by Molmil
K63-polyUb MDA5CARDs complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7DNI
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BU of 7dni by Molmil
MDA5 CARDs-MAVS CARD polyUb complex
Descriptor: Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin
Authors:Song, B, Chen, Y, Luo, D.H, Zheng, J.
Deposit date:2020-12-09
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7CRW
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BU of 7crw by Molmil
Cryo-EM structure of rNLRP1-rDPP9 complex
Descriptor: Dipeptidyl peptidase 9, NLR family protein 1
Authors:Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J.
Deposit date:2020-08-14
Release date:2021-03-24
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Nature, 592, 2021
7BKP
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BU of 7bkp by Molmil
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ...
Authors:Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y.
Deposit date:2021-01-16
Release date:2021-11-17
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Nat Commun, 12, 2021
6XKK
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BU of 6xkk by Molmil
Cryo-EM structure of the NLRP1-CARD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
Deposit date:2020-06-26
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6XKJ
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BU of 6xkj by Molmil
Cryo-EM structure of CARD8-CARD filament
Descriptor: Caspase recruitment domain-containing protein 8
Authors:Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
Deposit date:2020-06-26
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6N2P
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BU of 6n2p by Molmil
Helical assembly of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-11-13
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
6N2M
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BU of 6n2m by Molmil
NMR solution structure of the homodimeric, autoinhibited state of the CARD9 CARD and first coiled-coil
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Fairbrother, W.J, Dueber, E.C.
Deposit date:2018-11-13
Release date:2019-07-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019

 

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