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8SBS
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BU of 8sbs by Molmil
Fumarate C - R126A in (3-(N-morpholino)propanesulfonic acid) at pH 7.5
Descriptor: Fumarate hydratase class II
Authors:Weaver, T.M, May, J, Bhattacharyya, B.
Deposit date:2023-04-04
Release date:2023-11-15
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Fumarate C - R126A in (3-(N-morpholino)propanesulfonic acid) at pH 7.5
To Be Published
8JBD
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BU of 8jbd by Molmil
Crystal structure of Adenylosuccinate lyase from Thermus thermophilus HB8, TtPurB
Descriptor: Adenylosuccinate lyase
Authors:Nemoto, N, Kawai, G, Sampei, G.
Deposit date:2023-05-08
Release date:2023-11-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of adenylosuccinate lyase from the thermophilic bacterium Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 79, 2023
7T93
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Crystal Structure of Fumarate hydratase class II from Mycobacterium ulcerans in complex with L-Malate
Descriptor: (2S)-2-hydroxybutanedioic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Fumarate hydratase class II
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-17
Release date:2022-04-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Fumarate hydratase class II from Mycobacterium ulcerans in complex with L-Malate
to be published
7LUB
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BU of 7lub by Molmil
Crystal structure of recombinant human fumarase in complex with D-2-amino-3-phosphono-propionic acid
Descriptor: D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID, Fumarate hydratase, mitochondrial, ...
Authors:Cardoso, I.A, Nonato, M.C.
Deposit date:2021-02-21
Release date:2022-02-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
Science, 379, 2023
7T24
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BU of 7t24 by Molmil
Crystal Structure of Adenylosuccinate lyase (ASL) from Pseudomonas aeruginosa
Descriptor: Adenylosuccinate lyase, IMIDAZOLE, ISOPROPYL ALCOHOL
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-03
Release date:2021-12-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure of Adenylosuccinate lyase (ASL) from Pseudomonas aeruginosa
to be published
7T29
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BU of 7t29 by Molmil
Crystal Structure of Adenylosuccinate lyase (ASL) from Pseudomonas aeruginosa complexed with AMP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-12-03
Release date:2021-12-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Adenylosuccinate lyase (ASL) from Pseudomonas aeruginosa complexed with AMP
to be published
7C1C
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BU of 7c1c by Molmil
Crystal structure of FumaraseC from Mannheimia succiniciproducens
Descriptor: Fumarate hydratase class II, GLYCEROL
Authors:Kim, B, Lee, S.H, Kim, K.-J.
Deposit date:2020-05-02
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Biochemical analysis of FumaraseC from Mannheimia succiniciproducens
To Be Published
7C18
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BU of 7c18 by Molmil
Crystal structure of FumaraseC from Mannheimia succiniciproducens in complex with Fumarate
Descriptor: FUMARIC ACID, Fumarate hydratase class II
Authors:Kim, B, Lee, S.H, Kim, K.-J.
Deposit date:2020-05-02
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural studies reveal the molecular mechanism of isocitrate lyase from Chloroflexus aurantiacus
To Be Published
7C1A
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BU of 7c1a by Molmil
Crystal structure of FumaraseC (S319C) from Mannheimia succiniciproducens in complex with malate
Descriptor: (2S)-2-hydroxybutanedioic acid, Fumarate hydratase class II
Authors:Kim, B, Lee, S.H, Kim, K.-J.
Deposit date:2020-05-02
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.144 Å)
Cite:Structural and Biochemical analysis of FumaraseC from Mannheimia succiniciproducens
To Be Published
7MIW
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BU of 7miw by Molmil
Crystal Structure of Fumarate hydratase class II from Elizabethkingia anophelis NUHP1
Descriptor: 1,2-ETHANEDIOL, Fumarate hydratase class II
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-04-18
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of Fumarate hydratase class II from Elizabethkingia anophelis NUHP1
to be published
6VBE
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BU of 6vbe by Molmil
Crystal structure of recombinant mutant H180R of human fumarase
Descriptor: Fumarate hydratase, mitochondrial, GLYCEROL, ...
Authors:Ajalla, M.A.A, Nonato, M.C.
Deposit date:2019-12-18
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Crystal structure of recombinant mutant H180R of human fumarase
To Be Published
6V8F
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BU of 6v8f by Molmil
Crystal structure of recombinat mutant Q185R of human fumarase
Descriptor: CHLORIDE ION, Fumarate hydratase, mitochondrial, ...
Authors:Ajalla, M.A.A, Nonato, M.C.
Deposit date:2019-12-11
Release date:2020-12-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of recombinat mutant Q185R of human fumarase
To Be Published
6U4O
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BU of 6u4o by Molmil
Crystal structure of recombinant class II fumarase from Schistosoma mansoni
Descriptor: (2S)-2-hydroxybutanedioic acid, ACETATE ION, Fumarate hydratase, ...
Authors:Cardoso, I.A, Nonato, M.C.
Deposit date:2019-08-26
Release date:2020-09-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition.
Int.J.Biol.Macromol., 175, 2021
6P3C
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BU of 6p3c by Molmil
E. coli fumarase mutant - T187A
Descriptor: CITRATE ANION, Fumarate hydratase class II
Authors:May, J.F, Bhattcharyya, B, Weaver, T.M.
Deposit date:2019-05-23
Release date:2020-05-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.459 Å)
Cite:Fumarase C variant at the active site
To Be Published
6OS7
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BU of 6os7 by Molmil
E. coli fumarase mutant - R126A
Descriptor: CITRATE ANION, Fumarate hydratase class II, GLYCEROL
Authors:Stuttgen, G.M, May, J.F, Bhattcharyya, B, Weaver, T.M.
Deposit date:2019-05-01
Release date:2020-05-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Fumarase C variant that eliminates the B-site
To Be Published
6WNG
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BU of 6wng by Molmil
Crystal structure of an aspartate ammonia-lyase from Elizabethkingia anophelis NUHP1
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aspartate ammonia-lyase, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-04-22
Release date:2020-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of an aspartate ammonia-lyase from Elizabethkingia anophelis NUHP1
To Be Published
6RX8
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BU of 6rx8 by Molmil
EDDS lyase variant D290M/Y320M with bound fumarate
Descriptor: Argininosuccinate lyase, FUMARIC ACID, SODIUM ION
Authors:Grandi, E, Poelarends, G.J, Thunnissen, A.M.W.H.
Deposit date:2019-06-07
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.
Angew.Chem.Int.Ed.Engl., 59, 2020
6RXA
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BU of 6rxa by Molmil
EDDS lyase variant D290M/Y320M with bound formate
Descriptor: Argininosuccinate lyase, FORMIC ACID, GLYCEROL, ...
Authors:Grandi, E, Poelarends, G.J, Thunnissen, A.M.W.H.
Deposit date:2019-06-07
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.
Angew.Chem.Int.Ed.Engl., 59, 2020
6S7Z
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BU of 6s7z by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-07
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7U
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BU of 6s7u by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-06
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7W
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BU of 6s7w by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(quinolin-4-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-07
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S43
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BU of 6s43 by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azocan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-06-26
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7K
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BU of 6s7k by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-methylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S7S
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BU of 6s7s by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-(N-phenylsulfamoyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, ~{N}-[2-methoxy-5-(phenylsulfamoyl)phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-05
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019
6S88
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BU of 6s88 by Molmil
Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(2-Methoxy-5-((1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ...
Authors:Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C.
Deposit date:2019-07-08
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode.
J.Med.Chem., 62, 2019

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