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3T1U
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Crystal Structure of the complex of Cyclophilin-A enzyme from Azotobacter vinelandii with sucAFPFpNA peptide
Descriptor: Peptidyl-prolyl cis-trans isomerase, succinyl-Ala-Phe-Pro-Phe-p-nitroanilide
Authors:Karpusas, M, Christoforides, E, Bethanis, K, Dimou, M, Katinakis, P.
Deposit date:2011-07-22
Release date:2012-03-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a bacterial cytoplasmic cyclophilin A in complex with a tetrapeptide.
Acta Crystallogr.,Sect.F, 68, 2012
3UCH
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BU of 3uch by Molmil
Crystal structure of a peptidyl-prolyl cis-trans isomerase E (PPIE) from Homo sapiens at 2.50 A resolution
Descriptor: Peptidyl-prolyl cis-trans isomerase E
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2011-10-26
Release date:2011-11-16
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a Hypotherical Peptidyl-prolyl cis-trans isomerase E (PPIE) from Homo sapiens at 2.50 A resolution
To be published
8EJX
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Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor
Descriptor: N-phenyl-2-selanylbenzamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Lovell, S, Battaile, K.P, Yan, S.
Deposit date:2022-09-19
Release date:2023-10-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.
Brain, 2023
8HZ8
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Structure of PPIA in complex with the peptide of NRF2
Descriptor: NRF2 peptide, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Authors:Wanyan, W, Hui, M, Jin, H, Lu, W.
Deposit date:2023-01-08
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structure of PPIA in complex with the peptide of NRF2
To Be Published
5WC7
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BU of 5wc7 by Molmil
CypA Mutant - I97V S99T C115S
Descriptor: Peptidyl-prolyl cis-trans isomerase A
Authors:Fraser, J.S.
Deposit date:2017-06-29
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Rescue of conformational dynamics in enzyme catalysis by directed evolution.
Nat Commun, 9, 2018
5YB9
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BU of 5yb9 by Molmil
Crystal structure of a dimeric cyclophilin A from T.vaginalis
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Cho, C.C, Lin, M.H, Chou, C.C, Martin, T, Chen, C, Hsu, C.H.
Deposit date:2017-09-04
Release date:2018-07-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.276 Å)
Cite:Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
Sci Rep, 8, 2018
4R3F
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BU of 4r3f by Molmil
Structure of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27 from Chaetomium thermophilum
Descriptor: 1,2-ETHANEDIOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ACETATE ION, ...
Authors:Ulrich, A, Wahl, M.C.
Deposit date:2014-08-15
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27.
Acta Crystallogr.,Sect.D, 70, 2014
7L6Y
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Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes.
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Minasov, G, Shuvalova, L, Kiryukhina, O, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-12-24
Release date:2021-12-01
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Crystal Structure of the Peptidyl-Prolyl Cis-Trans Isomerase (PpiB) from Streptococcus pyogenes.
To Be Published
7L6Z
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Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-12-24
Release date:2021-12-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of Peptidyl-Prolyl Cis-Trans Isomerasefrom (PpiB) Streptococcus pneumoniae R6
To Be Published
4TOT
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Crystal structure of rat cyclophilin D in complex with a potent nonimmunosuppressive inhibitor
Descriptor: HEXAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase F, mitochondrial, ...
Authors:Knapp, M.S, Elling, R.A.
Deposit date:2014-06-06
Release date:2014-11-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
J.Med.Chem., 57, 2014
4S1E
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Crystal structure of cyclophilin mutant L120A from Leishmania donovani at 2.22 angstrom.
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Roy, S, Datta, A.K, Banerjee, R.
Deposit date:2015-01-13
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Characterization and prediction of thermal stability of cyclophilin mutants from L.donovani
To be Published
4S1J
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Crystal structure of cyclophilin mutant V33A from Leishmania donovani at 2.3 angstrom.
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Roy, S, Datta, A.K, Banerjee, R.
Deposit date:2015-01-14
Release date:2015-03-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization and prediction of thermal stability of cyclophilin mutants from L.donovani
To be Published
8B58
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Crystal Structure of Cyclophilin TgCyp23 from Toxoplasma gondii in complex with Cyclosporin A
Descriptor: Cyclosporin A, Peptidyl-prolyl cis-trans isomerase
Authors:Jimenez-Faraco, E, Hermoso, J.A.
Deposit date:2022-09-22
Release date:2023-02-01
Last modified:2023-02-22
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural Basis for Cyclosporin Isoform-Specific Inhibition of Cyclophilins from Toxoplasma gondii .
Acs Infect Dis., 9, 2023
7N3J
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BU of 7n3j by Molmil
E. coli peptidyl-prolyl cis-trans isomerase, mutant Phe27CF3-Tyr/Phe98CF3-Tyr
Descriptor: Peptidyl-prolyl cis-trans isomerase B
Authors:Frkic, R.L, Otting, G, Jackson, C.J.
Deposit date:2021-06-01
Release date:2021-09-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Through-Space Scalar 19 F- 19 F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins.
J.Am.Chem.Soc., 143, 2021
8CU5
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BU of 8cu5 by Molmil
Crystal Structure of Putative Cyclophilin B from Brugia malayi
Descriptor: 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-05-16
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Putative Cyclophilin B from Brugia malayi
to be published
1DYW
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BU of 1dyw by Molmil
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans
Descriptor: CYCLOPHILIN 3
Authors:Dornan, J, Page, A.P, Taylor, P, Wu, S.Y, Winter, A.D, Husi, H, Walkinshaw, M.D.
Deposit date:2000-02-10
Release date:2000-06-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis Elegans
J.Biol.Chem., 274, 1999
3BO7
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Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136
Descriptor: 1,2-ETHANEDIOL, CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYCLOPHILIN-TYPE, ...
Authors:Wernimont, A.K, Lew, J, Kozieradzki, I, Lin, Y.H, Sun, X, Khuu, C, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Hui, R, Artz, J.D, Xiao, T, Structural Genomics Consortium (SGC)
Deposit date:2007-12-17
Release date:2008-02-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of Toxoplasma Gondii Peptidyl-Prolyl Cis-Trans Isomerase, 541.M00136.
To be Published
1E3B
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CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3
Descriptor: CYCLOPHILIN 3, GOLD ION, TRIETHYLPHOSPHANE
Authors:Zou, J, Taylor, P, Dornan, J, Robinson, S.P, Walkinshaw, M.D, Sadler, P.J.
Deposit date:2000-06-08
Release date:2000-10-22
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:First Crystal Structure of a Medicinally Relevant Gold Protein Complex:Unexpected Binding of [Au(Pet (3))](+) to Histidine
Angew.Chem.Int.Ed.Engl., 39, 2000
3BT8
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BU of 3bt8 by Molmil
Crystal Structure of Mutant Cyclophilin (R147A) from Leishmania donovani
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Venugopal, V, Sen, B, Datta, A.K, Banerjee, R.
Deposit date:2007-12-28
Release date:2008-01-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Mutant Cyclophilin from Leishmania Donovani
To be Published
1E8K
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Cyclophilin 3 Complexed With Dipeptide Ala-Pro
Descriptor: ALANINE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3, PROLINE
Authors:Wu, S.Y, Dornan, J, Kontopidis, G, Taylor, P, Walkinshaw, M.D.
Deposit date:2000-09-25
Release date:2001-09-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The First Direct Determination of a Ligand Binding Constant in Protein Crystals
Angew.Chem.Int.Ed.Engl., 40, 2001
3CYH
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BU of 3cyh by Molmil
CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO
Descriptor: CYCLOPHILIN A, PROLINE, SERINE
Authors:Zhao, Y, Ke, H.
Deposit date:1996-02-27
Release date:1996-07-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry, 35, 1996
3CYS
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BU of 3cys by Molmil
DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
Authors:Spitzfaden, C, Braun, W, Wider, G, Widmer, H, Wuthrich, K.
Deposit date:1994-02-28
Release date:1994-08-31
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Determination of the NMR Solution Structure of the Cyclophilin A-Cyclosporin a Complex.
J.Biomol.NMR, 4, 1994
1FGL
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Cyclophilin A complexed with a fragment of HIV-1 GAG protein
Descriptor: CYCLOPHILIN A, HIV-1 GAG PROTEIN
Authors:Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H.
Deposit date:1996-11-18
Release date:1997-04-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.
Structure, 5, 1997
3EOV
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Crystal structure of cyclophilin from Leishmania donovani ligated with cyclosporin A
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
Authors:Venugopal, V, Dasgupta, D, Datta, A.K, Banerjee, R.
Deposit date:2008-09-29
Release date:2008-11-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Cyclophilin from Leishmania Donovani Bound to Cyclosporin at 2.6 A Resolution: Correlation between Structure and Thermodynamic Data.
Acta Crystallogr.,Sect.D, 65, 2009
1H0P
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Cyclophilin_5 from C. elegans
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 5
Authors:Picken, N.C, Eschenlauer, S, Taylor, P, Page, A.P, Walkinshaw, M.D.
Deposit date:2002-06-26
Release date:2002-09-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Biological Characterisation of the Gut-Associated Cyclophilin B Isoforms from Caenorhabditis Elegans
J.Mol.Biol., 322, 2002

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