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1POU
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BU of 1pou by Molmil
THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN
Descriptor: OCT-1
Authors:Assa-Munt, N, Mortishire-Smith, R.J, Aurora, R, Herr, W, Wright, P.E.
Deposit date:1993-06-14
Release date:1994-10-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.
Cell(Cambridge,Mass.), 73, 1993
1GT0
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BU of 1gt0 by Molmil
Crystal structure of a POU/HMG/DNA ternary complex
Descriptor: 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ...
Authors:Remenyi, A, Wilmanns, M.
Deposit date:2002-01-09
Release date:2003-01-30
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers
Genes Dev., 17, 2003
1AU7
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BU of 1au7 by Molmil
PIT-1 MUTANT/DNA COMPLEX
Descriptor: CONSENSUS DNA 25-MER, DNA (5'-D(*CP*TP*TP*CP*CP*TP*CP*AP*TP*GP*TP*AP*TP*AP*TP*AP*C P*AP*TP*GP*AP*GP* GP*A)-3'), PROTEIN PIT-1
Authors:Jacobson, E.M, Li, P, Leon-Del-Rio, A, Rosenfeld, M.G, Aggarwal, A.K.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.
Genes Dev., 11, 1997
5WC9
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BU of 5wc9 by Molmil
Human Pit-1 and 4xCATT DNA complex
Descriptor: DNA (5'-D(*CP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*GP*GP*A)-3'), DNA (5'-D(*CP*CP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*GP*T)-3'), Pituitary-specific positive transcription factor 1
Authors:Agarwal, S, Cho, T.Y.
Deposit date:2017-06-29
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.
Nucleic Acids Res., 46, 2018
6T90
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BU of 6t90 by Molmil
OCT4-SOX2-bound nucleosome - SHL-6
Descriptor: DNA (146-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2019-10-25
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
6HT5
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BU of 6ht5 by Molmil
Oct4/Sox2:UTF1 structure
Descriptor: DNA (5'-D(*TP*TP*CP*AP*CP*TP*AP*GP*CP*AP*TP*AP*AP*CP*AP*AP*TP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*CP*AP*TP*TP*GP*TP*TP*AP*TP*GP*CP*TP*AP*GP*TP*GP*AP*AP*G)-3'), POU domain, ...
Authors:Vahokoski, J, Meusch, D, Groves, M, Pogenberg, V, Wilmanns, M.
Deposit date:2018-10-03
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.451 Å)
Cite:Oct4/Sox2:UTF1 structure
To Be Published
6YOV
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BU of 6yov by Molmil
OCT4-SOX2-bound nucleosome - SHL+6
Descriptor: DNA (142-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2020-04-15
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
8OTS
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BU of 8ots by Molmil
OCT4 and MYC-MAX co-bound to a nucleosome
Descriptor: DNA (127-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.
Deposit date:2023-04-21
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
3D1N
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BU of 3d1n by Molmil
Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
Descriptor: 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DA)-3', 5'-D(*DTP*DTP*DAP*DTP*DTP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DCP*DT)-3', POU domain, ...
Authors:Pereira, J.H, Ha, S.C, Kim, S.-H.
Deposit date:2008-05-06
Release date:2009-05-26
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of human Brn-5 transcription factor in complex with CRH gene promoter.
J.Struct.Biol., 167, 2009
7XRC
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BU of 7xrc by Molmil
Crystal Structure of the dimeric Brn2 (Pou3f2) POU domain bound to palindromic MORE DNA
Descriptor: More palindromic Oct factor Recognition Element (MORE), POU domain protein
Authors:Tan, D.S.Y, Jauch, R.
Deposit date:2022-05-10
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The homeodomain of Oct4 is a dimeric binder of methylated CpG elements.
Nucleic Acids Res., 51, 2023
2XSD
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BU of 2xsd by Molmil
Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA
Descriptor: 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ...
Authors:Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R.
Deposit date:2010-09-28
Release date:2010-10-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA.
Proteins, 79, 2011
3L1P
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BU of 3l1p by Molmil
POU protein:DNA complex
Descriptor: DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ...
Authors:Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M.
Deposit date:2009-12-14
Release date:2010-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat.Cell Biol., 15, 2013
8SPS
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BU of 8sps by Molmil
High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b
Descriptor: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2023-05-03
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
8SPU
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BU of 8spu by Molmil
Structure of ESRRB nucleosome bound OCT4 at site c
Descriptor: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2023-05-03
Release date:2023-06-28
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
8BX1
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BU of 8bx1 by Molmil
Oct4/Sox2 protein:DNA complex
Descriptor: HOXB1_f, HOXB1_r, POU domain, ...
Authors:Chojnowski, G, Wilmanns, M, Round, E.
Deposit date:2022-12-07
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Oct4-Soc2-HoxB1 complex
To Be Published
8BX2
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BU of 8bx2 by Molmil
Oct4/Sox2 protein:DNA complex
Descriptor: POU domain, class 5, transcription factor 1, ...
Authors:Chojnowski, G, Wilmanns, M, Round, E.
Deposit date:2022-12-07
Release date:2023-12-20
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of Oct4-Soc2-UTF1 complex
To Be Published
7U0G
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BU of 7u0g by Molmil
structure of LIN28b nucleosome bound 3 OCT4
Descriptor: DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Lian, T, Guan, R, Bai, Y.
Deposit date:2022-02-18
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
7U0I
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BU of 7u0i by Molmil
Structure of LIN28b nucleosome bound 2 OCT4
Descriptor: DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ...
Authors:Tengfei, L, Guan, R, Bai, Y.
Deposit date:2022-02-18
Release date:2023-06-28
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
1CQT
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BU of 1cqt by Molmil
CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT
Descriptor: DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), POU DOMAIN, ...
Authors:Chasman, D.I, Cepek, K, Sharp, P.A, Pabo, C.O.
Deposit date:1999-08-11
Release date:1999-11-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.
Genes Dev., 13, 1999
1O4X
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BU of 1o4x by Molmil
TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Descriptor: 5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3', Transcription factor SOX-2, ...
Authors:Clore, G.M, Williams, D.C.
Deposit date:2003-07-17
Release date:2004-01-27
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.
J.Biol.Chem., 279, 2004
1E3O
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BU of 1e3o by Molmil
Crystal structure of Oct-1 POU dimer bound to MORE
Descriptor: 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1
Authors:Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M.
Deposit date:2000-06-20
Release date:2001-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping
Mol.Cell, 8, 2001
1OCT
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BU of 1oct by Molmil
CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES
Descriptor: DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), PROTEIN (OCT-1 POU DOMAIN)
Authors:Klemm, J.D, Rould, M.A, Aurora, R, Herr, W, Pabo, C.O.
Deposit date:1994-05-09
Release date:1994-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.
Cell(Cambridge,Mass.), 77, 1994
1HF0
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BU of 1hf0 by Molmil
Crystal structure of the DNA-binding domain of Oct-1 bound to DNA as a dimer
Descriptor: DNA 5'-D(*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP* CP*AP*AP*AP*TP*GP*GP*AP*G)-3', DNA 5'-D(*CP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP* TP*CP*AP*AP*AP*TP*GP*TP*G)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1
Authors:Remenyi, A, Tomilin, A, Pohl, E, Scholer, H.R, Wilmanns, M.
Deposit date:2000-11-27
Release date:2001-11-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping
Mol.Cell, 8, 2001
8G87
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BU of 8g87 by Molmil
Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region)
Descriptor: POU domain, class 5, transcription factor 1, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G8E
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BU of 8g8e by Molmil
Human Oct4 bound to nucleosome with human LIN28B sequence
Descriptor: LIN28B DNA (32-MER), POU domain, class 5, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023

 

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