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8H9H
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BU of 8h9h by Molmil
Crystal structure of ZBTB7A in complex with GACCC-containing sequence
Descriptor: DNA (5'-D(*TP*AP*AP*GP*GP*AP*CP*CP*CP*AP*GP*AP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*GP*GP*GP*TP*CP*CP*TP*T)-3'), ZINC ION, ...
Authors:Yang, Y.
Deposit date:2022-10-25
Release date:2023-04-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ZBTB7A regulates primed-to-naive transition of pluripotent stem cells via recognition of the PNT-associated sequence by zinc fingers 1-2 and recognition of gamma-globin -200 gene element by zinc fingers 1-4.
Febs J., 290, 2023
8A4I
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BU of 8a4i by Molmil
Crystal structure of SALL4 zinc finger cluster 4 with AT-rich DNA
Descriptor: DNA (5'-D(*GP*AP*TP*AP*TP*TP*AP*AP*TP*AP*TP*C)-3'), MAGNESIUM ION, Sal-like protein 4, ...
Authors:Watson, J.A, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A, Cook, A.G.
Deposit date:2022-06-11
Release date:2023-01-11
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.
Life Sci Alliance, 6, 2023
7EYI
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BU of 7eyi by Molmil
Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation
Descriptor: BORIC ACID, DNA (5'-D(*AP*TP*AP*GP*GP*GP*CP*CP*CP*CP*TP*TP*CP*CP*CP*AP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*GP*GP*AP*AP*GP*GP*GP*GP*CP*CP*CP*TP*A)-3'), ...
Authors:Yang, Y, Shi, Y.Y.
Deposit date:2021-05-31
Release date:2021-09-01
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structural basis for human ZBTB7A action at the fetal globin promoter.
Cell Rep, 36, 2021
7TXC
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BU of 7txc by Molmil
HIC2 zinc finger domain in complex with the DNA binding motif-2 of the BCL11A enhancer
Descriptor: DNA (5'-D(*AP*CP*TP*GP*TP*TP*GP*GP*CP*AP*TP*TP*AP*TP*CP*T)-3'), DNA (5'-D(*AP*GP*AP*TP*AP*AP*TP*GP*CP*CP*AP*AP*CP*AP*GP*T)-3'), Hypermethylated in cancer 2 protein, ...
Authors:Horton, J.R, Ren, R, Cheng, X.
Deposit date:2022-02-08
Release date:2022-06-01
Last modified:2022-09-28
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
Nat.Genet., 54, 2022
1ARF
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BU of 1arf by Molmil
STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
Descriptor: YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
Authors:Hoffman, R.C, Xu, R.X, Horvath, S.J, Herriott, J.R, Klevit, R.E.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
3ZNF
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BU of 3znf by Molmil
HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION
Descriptor: ZINC FINGER, ZINC ION
Authors:Gronenborn, A.M, Clore, G.M, Omichinski, J.G.
Deposit date:1990-07-09
Release date:1992-01-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.
Biochemistry, 29, 1990
1BBO
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BU of 1bbo by Molmil
HIGH-RESOLUTION SOLUTION STRUCTURE OF THE DOUBLE CYS2*HIS2 ZINC FINGER FROM THE HUMAN ENHANCER BINDING PROTEIN MBP-1
Descriptor: HUMAN ENHANCER-BINDING PROTEIN MBP-1, ZINC ION
Authors:Clore, G.M, Omichinski, J.G, Gronenborn, A.M.
Deposit date:1992-05-01
Release date:1993-10-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1.
Biochemistry, 31, 1992
4M9E
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BU of 4m9e by Molmil
Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA
Descriptor: ACETATE ION, DNA (5'-D(*GP*AP*GP*GP*(5CM)P*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*(5CM)P*GP*CP*CP*TP*C)-3'), ...
Authors:Liu, Y, Olanrewaju, Y.O, Blumenthal, R.M, Zhang, X, Cheng, X.
Deposit date:2013-08-14
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for Klf4 recognition of methylated DNA.
Nucleic Acids Res., 42, 2014
4M9V
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BU of 4m9v by Molmil
Zfp57 mutant (E182Q) in complex with 5-carboxylcytosine DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Liu, Y, Olanrewaju, Y.O, Zhang, X, Cheng, X.
Deposit date:2013-08-15
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (0.969 Å)
Cite:DNA recognition of 5-carboxylcytosine by a zfp57 mutant at an atomic resolution of 0.97 angstrom.
Biochemistry, 52, 2013
6E93
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BU of 6e93 by Molmil
Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 in complex with methylated DNA
Descriptor: DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ...
Authors:Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A.
Deposit date:2018-07-31
Release date:2018-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38.
J. Biol. Chem., 293, 2018
6E94
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BU of 6e94 by Molmil
Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R in complex with methylated DNA
Descriptor: DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ...
Authors:Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A.
Deposit date:2018-07-31
Release date:2018-11-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38.
J. Biol. Chem., 293, 2018
3UK3
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BU of 3uk3 by Molmil
Crystal structure of ZNF217 bound to DNA
Descriptor: 5'-D(*AP*AP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', CHLORIDE ION, ...
Authors:Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P.
Deposit date:2011-11-08
Release date:2012-12-05
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rediscovering DNA recognition by classical Zinc Fingers.
To be Published
6VTX
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BU of 6vtx by Molmil
Crystal structure of human KLF4 zinc finger DNA binding domain in complex with NANOG DNA
Descriptor: DNA (5'-D(*AP*GP*GP*GP*GP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*CP*AP*CP*CP*CP*CP*CP*T)-3'), Krueppel-like factor 4, ...
Authors:Sharma, R, Sharma, S, Choi, K.J, Ferreon, A.C.M, Ferreon, J.C, Sankaran, B, MacKenzie, K.R, Kim, C.
Deposit date:2020-02-13
Release date:2021-09-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.
Nat Commun, 12, 2021
4F2J
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BU of 4f2j by Molmil
Crystal structure of ZNF217 bound to DNA, P6522 crystal form
Descriptor: 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', ZINC ION, Zinc finger protein 217
Authors:Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P.
Deposit date:2012-05-08
Release date:2013-02-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217
J.Biol.Chem., 288, 2013
4X9J
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BU of 4x9j by Molmil
EGR-1 with Doubly Methylated DNA
Descriptor: DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), Early growth response protein 1, ...
Authors:White, M.A, Zandarashvili, L, Iwahara, J.
Deposit date:2014-12-11
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.412 Å)
Cite:Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.
Febs Lett., 589, 2015
6WMI
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BU of 6wmi by Molmil
ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*CP*AP*TP*AP*AP*TP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*TP*AP*TP*GP*GP*GP*AP*TP*GP*TP*G)-3'), ...
Authors:Ren, R, Horton, J.R, Cheng, X.
Deposit date:2020-04-21
Release date:2020-12-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Mol.Cell, 81, 2021
6WLH
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BU of 6wlh by Molmil
RNA complex of WT1 zinc finger transcription factor
Descriptor: RNA (29-MER), Wilms tumor protein, ZINC ION
Authors:Wright, P.E, Dyson, H.J.
Deposit date:2020-04-20
Release date:2021-03-03
Method:SOLUTION NMR
Cite:RNA Binding by the KTS Splice Variants of Wilms' Tumor Suppressor Protein WT1.
Biochemistry, 59, 2020
1JK1
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BU of 1jk1 by Molmil
Zif268 D20A Mutant Bound to WT DNA Site
Descriptor: 5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*GP*G)-3', 5'-D(*TP*CP*CP*GP*CP*CP*CP*AP*CP*GP*C)-3', ZIF268, ...
Authors:Miller, J.C, Pabo, C.O.
Deposit date:2001-07-11
Release date:2001-10-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition.
J.Mol.Biol., 313, 2001
4GZN
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BU of 4gzn by Molmil
Mouse ZFP57 zinc fingers in complex with methylated DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Liu, Y, Zhang, X, Cheng, X.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence.
Genes Dev., 26, 2012
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-05-17
Release date:2023-05-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
1F2I
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BU of 1f2i by Molmil
COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA
Descriptor: 5'-D(*AP*TP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*AP*T)-3', FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, ZINC ION
Authors:Wang, B.S, Grant, R.A, Pabo, C.O.
Deposit date:2000-05-25
Release date:2001-09-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA.
Nat.Struct.Biol., 8, 2001
1JK2
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BU of 1jk2 by Molmil
Zif268 D20A mutant bound to the GCT DNA site
Descriptor: 5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*CP*CP*CP*AP*CP*GP*C)-3', ZIF268, ...
Authors:Miller, J.C, Pabo, C.O.
Deposit date:2001-07-11
Release date:2001-10-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition.
J.Mol.Biol., 313, 2001
4ZNF
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BU of 4znf by Molmil
HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION
Descriptor: ZINC FINGER, ZINC ION
Authors:Gronenborn, A.M, Clore, G.M, Omichinski, J.G.
Deposit date:1990-07-09
Release date:1992-01-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.
Biochemistry, 29, 1990
5A7U
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BU of 5a7u by Molmil
Single-particle cryo-EM of co-translational folded adr1 domain inside the E. coli ribosome exit tunnel.
Descriptor: REGULATORY PROTEIN ADR1, ZINC ION
Authors:Nilsson, O.B, Hedman, R, Marino, J, Wickles, S, Bischoff, L, Johansson, M, Muller-Lucks, A, Trovato, F, Puglisi, J.D, O'Brien, E, Beckmann, R, von Heijne, G.
Deposit date:2015-07-10
Release date:2015-09-16
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cotranslational Protein Folding Inside the Ribosome Exit Tunnel.
Cell Rep., 12, 2015
5EH2
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BU of 5eh2 by Molmil
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III
Descriptor: DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ...
Authors:Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X.
Deposit date:2015-10-27
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for human PRDM9 action at recombination hot spots.
Genes Dev., 30, 2016

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