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1BYU
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BU of 1byu by Molmil
CANINE GDP-RAN
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (GTP-BINDING PROTEIN RAN)
Authors:Stewart, M, Kent, H.M, Mccoy, A.J.
Deposit date:1998-10-18
Release date:1998-12-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
J.Mol.Biol., 284, 1998
821P
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BU of 821p by Molmil
THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
Descriptor: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Scheidig, A.J, Krengel, U, Pai, E.F, Kabsch, W, Wittinghofer, A, Goody, R.S.
Deposit date:1993-03-29
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
8AFD
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BU of 8afd by Molmil
CRYSTAL STRUCTURE OF BIT-BLOCKED KRAS-G12V-S39C IN COMPLEX WITH COMPOUND 20a
Descriptor: (4~{S})-4-[3-(4-aminophenyl)-1,2,4-oxadiazol-5-yl]-2-azanyl-4-methyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile, 1H-benzimidazol-2-ylmethanethiol, GTPase KRas, ...
Authors:Boettcher, J, Kessler, D.
Deposit date:2022-07-16
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.633 Å)
Cite:Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
J.Med.Chem., 65, 2022
8AFB
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CRYSTAL STRUCTURE OF KRAS-G12C IN COMPLEX WITH COMPOUND 23 (BI-0474)
Descriptor: (4~{S})-2-azanyl-4-[3-[6-[(2~{S})-2,4-dimethylpiperazin-1-yl]-4-(4-prop-2-enoylpiperazin-1-yl)pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-4-methyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Boettcher, J, Kessler, D.
Deposit date:2022-07-16
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
J.Med.Chem., 65, 2022
8AFC
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CRYSTAL STRUCTURE OF KRAS-G12C IN COMPLEX WITH COMPOUND 12
Descriptor: 2-azanyl-4,4-dimethyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Boettcher, J, Kessler, D.
Deposit date:2022-07-16
Release date:2022-11-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
J.Med.Chem., 65, 2022
121P
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BU of 121p by Molmil
STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS
Descriptor: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Krengel, U, Scheffzek, K, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Struktur Und Guanosintriphosphat-Hydrolysemechanismus Des C-Terminal Verkuerzten Menschlichen Krebsproteins P21-H-Ras
Thesis, 1991
1A4R
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BU of 1a4r by Molmil
G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM
Descriptor: AMINOPHOSPHONIC ACID-GUANYLATE ESTER, G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Rudolph, M.G, Vetter, I.R, Wittinghofer, A.
Deposit date:1998-02-02
Release date:1999-03-02
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein Sci., 8, 1999
4WA7
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BU of 4wa7 by Molmil
Crystal Structure of a GDP-bound Q61L Oncogenic Mutant of Human GT- Pase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-08-28
Release date:2015-06-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
1AGP
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BU of 1agp by Molmil
THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS
Descriptor: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Franken, S.M, Scheidig, A.J, Wittinghofer, A, Goody, R.S.
Deposit date:1993-03-29
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1AN0
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BU of 1an0 by Molmil
CDC42HS-GDP COMPLEX
Descriptor: CDC42HS-GDP, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kongsaeree, P, Cerione, R, Clardy, J.
Deposit date:1997-06-26
Release date:1999-01-13
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure Determination of Cdc42Hs and Gdp Complex
To be Published
1A2B
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BU of 1a2b by Molmil
HUMAN RHOA COMPLEXED WITH GTP ANALOGUE
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN RHOA
Authors:Ihara, K, Muraguchi, S, Kato, M, Shimizu, T, Shirakawa, M, Kuroda, S, Kaibuchi, K, Hakoshima, T.
Deposit date:1997-12-26
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J.Biol.Chem., 273, 1998
1AJE
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BU of 1aje by Molmil
CDC42 FROM HUMAN, NMR, 20 STRUCTURES
Descriptor: CDC42HS
Authors:Feltham, J.L, Dotsch, V, Raza, S, Manor, D, Cerione, R.A, Sutcliffe, M.J, Wagner, G, Oswald, R.E.
Deposit date:1997-05-02
Release date:1997-11-12
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry, 36, 1997
1AA9
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BU of 1aa9 by Molmil
HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: C-HA-RAS, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Ito, Y, Yamasaki, Y, Muto, Y, Kawai, G, Nishimura, S, Miyazawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1997-01-27
Release date:1997-07-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
Biochemistry, 36, 1997
5KYK
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BU of 5kyk by Molmil
Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Descriptor: 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas
Authors:Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S.
Deposit date:2016-07-21
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
5LEF
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BU of 5lef by Molmil
Rab6A:Kif20A complex
Descriptor: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ISOPROPYL ALCOHOL, ...
Authors:Bressanelli, G, Pylypenko, O, Houdusse, A.
Deposit date:2016-06-29
Release date:2017-11-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.
Nat Commun, 8, 2017
5MLB
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BU of 5mlb by Molmil
Crystal structure of human RAS in complex with darpin K27
Descriptor: DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2016-12-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5MLA
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BU of 5mla by Molmil
Crystal structure of human RAS in complex with darpin K55
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2016-12-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5N6O
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BU of 5n6o by Molmil
Wild type human Rac1-GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1
Authors:Cherfils, J, Ferrandez, Y.
Deposit date:2017-02-15
Release date:2017-12-27
Last modified:2020-11-18
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.
Sci Rep, 7, 2017
4XVQ
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BU of 4xvq by Molmil
H-Ras Y137E
Descriptor: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Mattos, C.
Deposit date:2015-01-27
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
4XVR
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BU of 4xvr by Molmil
H-Ras Y137F
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Mattos, C.
Deposit date:2015-01-27
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
4Z8Y
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BU of 4z8y by Molmil
Crystal structure of Rab GTPase Sec4p mutant - S29V
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein SEC4, ...
Authors:Rinadi, F.C, Collins, R.N.
Deposit date:2015-04-09
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Bmc Struct.Biol., 15, 2015
5A0F
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BU of 5a0f by Molmil
Crystal structure of Yersinia Afp18-modified RhoA
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Jank, T, Schimpl, M, van Aalten, D.M.
Deposit date:2015-04-20
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.
Nat Commun, 6, 2015
521P
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BU of 521p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, H-RAS P21 PROTEIN, MAGNESIUM ION
Authors:Schlichting, I, Krengel, U, Kabsch, W, Wittinghofer, A, Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
7OK4
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BU of 7ok4 by Molmil
Crystal Structure of KRasG13C in Complex with Nucleotide-based covalent Inhibitor bdaGDP
Descriptor: Isoform 2B of GTPase KRas, bdaGDP
Authors:Goebel, L, Mueller, M.P, Rauh, D.
Deposit date:2021-05-17
Release date:2022-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.
Elife, 12, 2023
7OK3
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Crystal Structure of KRasG13C in Complex with Nucleotide-based Covalent Inhibitor edaGDP
Descriptor: Isoform 2B of GTPase KRas, edaGDP
Authors:Goebel, L, Mueller, M.P, Rauh, D.
Deposit date:2021-05-17
Release date:2022-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.
Elife, 12, 2023

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