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4JSV
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BU of 4jsv by Molmil
mTOR kinase structure, mechanism and regulation.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ...
Authors:Pavletich, N.P, Yang, H.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
5FLC
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BU of 5flc by Molmil
Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction
Descriptor: FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ...
Authors:Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T.
Deposit date:2015-10-23
Release date:2015-12-30
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Architecture of Human Mtor Complex 1
Science, 351, 2016
7PEC
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BU of 7pec by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PEB
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BU of 7peb by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE9
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BU of 7pe9 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE8
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BU of 7pe8 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PEA
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BU of 7pea by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE7
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BU of 7pe7 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-15
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
5ZCS
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BU of 5zcs by Molmil
4.9 Angstrom Cryo-EM structure of human mTOR complex 2
Descriptor: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ...
Authors:Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y.
Deposit date:2018-02-20
Release date:2018-03-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cryo-EM structure of human mTOR complex 2.
Cell Res., 28, 2018
4JSN
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BU of 4jsn by Molmil
structure of mTORdeltaN-mLST8 complex
Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JSP
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BU of 4jsp by Molmil
structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ...
Authors:Pavletich, N.P, Yang, H.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JT5
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BU of 4jt5 by Molmil
mTORdeltaN-mLST8-pp242 complex
Descriptor: 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P, Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JSX
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BU of 4jsx by Molmil
structure of mTORDeltaN-mLST8-Torin2 complex
Descriptor: 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P, Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JT6
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BU of 4jt6 by Molmil
structure of mTORDeltaN-mLST8-PI-103 complex
Descriptor: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR
Authors:Pavletich, N.P, Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
5H64
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BU of 5h64 by Molmil
Cryo-EM structure of mTORC1
Descriptor: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
7OWG
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BU of 7owg by Molmil
human DEPTOR in a complex with mutant human mTORC1 A1459P
Descriptor: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ...
Authors:Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife, 10, 2021
8PPZ
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BU of 8ppz by Molmil
Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
Descriptor: (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, CALCIUM ION, ...
Authors:Meyners, C, Deutscher, R.C.E, Hausch, F.
Deposit date:2023-07-10
Release date:2023-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
Chemrxiv, 2023
3JBZ
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BU of 3jbz by Molmil
Crystal structure of mTOR docked into EM map of dimeric ATM kinase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ...
Authors:Lau, W.C.Y.
Deposit date:2015-11-03
Release date:2016-11-16
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (28 Å)
Cite:Structure of the human dimeric ATM kinase.
Cell Cycle, 15, 2016
2NPU
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BU of 2npu by Molmil
The solution structure of the rapamycin-binding domain of mTOR (FRB)
Descriptor: FKBP12-rapamycin complex-associated protein
Authors:Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
6ZWO
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BU of 6zwo by Molmil
cryo-EM structure of human mTOR complex 2, focused on one half
Descriptor: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T.
Deposit date:2020-07-28
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
2GAQ
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BU of 2gaq by Molmil
NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR
Descriptor: FKBP12-rapamycin complex-associated protein
Authors:Leone, M, Pellecchia, M.
Deposit date:2006-03-09
Release date:2006-08-08
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design.
Biochemistry, 45, 2006
6ZWM
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BU of 6zwm by Molmil
cryo-EM structure of human mTOR complex 2, overall refinement
Descriptor: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T.
Deposit date:2020-07-28
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
2RSE
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BU of 2rse by Molmil
NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, TERBIUM(III) ION
Authors:Kobashigawa, Y, Ushio, M, Saio, T, Inagaki, F.
Deposit date:2012-01-25
Release date:2012-05-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination.
J.Biomol.Nmr, 53, 2012
5WBH
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BU of 5wbh by Molmil
Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
Descriptor: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR
Authors:Pavletich, N.P, Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5OQ4
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BU of 5oq4 by Molmil
PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
Descriptor: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Williams, R.L, Zhang, X.
Deposit date:2017-08-10
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.
J. Med. Chem., 60, 2017

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