6QTP
2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 9 |
| 詳細 | binding site for residue MN B 701 |
| 鎖名 | 残基 |
| B | GLU435 |
| B | ASP508 |
| B | ASP510 |
| B | HOH806 |
| B | HOH810 |
| B | HOH825 |
| B | HOH831 |
| E | DA9 |
| E | HOH223 |
| site_id | AC2 |
| 残基数 | 2 |
| 詳細 | binding site for residue NA B 702 |
| 鎖名 | 残基 |
| B | GLU427 |
| B | GLU428 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | binding site for residue GOL A 501 |
| 鎖名 | 残基 |
| A | ASP96 |
| A | PHE97 |
| A | MET113 |
| A | PRO219 |
| A | THR220 |
| A | ARG485 |
| site_id | AC4 |
| 残基数 | 7 |
| 詳細 | binding site for residue MN D 701 |
| 鎖名 | 残基 |
| A | TYR123 |
| A | HOH609 |
| D | GLU435 |
| D | ASP508 |
| D | HOH807 |
| F | DC8 |
| F | DA9 |
| site_id | AC5 |
| 残基数 | 4 |
| 詳細 | binding site for residue SO4 C 501 |
| 鎖名 | 残基 |
| A | ARG429 |
| C | ARG429 |
| C | HOH739 |
| C | HOH800 |
| site_id | AC6 |
| 残基数 | 14 |
| 詳細 | binding site for residue JHN E 101 |
| 鎖名 | 残基 |
| A | ALA68 |
| A | MET75 |
| A | ASP83 |
| A | MET121 |
| A | HOH797 |
| C | ALA68 |
| C | MET75 |
| C | ASP83 |
| C | MET121 |
| E | DG10 |
| E | DC11 |
| E | HOH235 |
| F | DG10 |
| F | DC11 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897 |
| 鎖名 | 残基 | 詳細 |
| A | TYR123 | |
| C | TYR123 | |
| B | ASP510 | |
| D | GLU435 | |
| D | ASP508 | |
| D | ASP510 |
| site_id | SWS_FT_FI2 |
| 残基数 | 4 |
| 詳細 | SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898 |
| 鎖名 | 残基 | 詳細 |
| B | LYS460 | |
| B | ASN463 | |
| D | LYS460 | |
| D | ASN463 |
