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6OKK

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit

Functional Information from GO Data
ChainGOidnamespacecontents
B0003735molecular_functionstructural constituent of ribosome
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005840cellular_componentribosome
B0006412biological_processtranslation
B0022627cellular_componentcytosolic small ribosomal subunit
B1990904cellular_componentribonucleoprotein complex
C0000028biological_processribosomal small subunit assembly
C0002181biological_processcytoplasmic translation
C0003735molecular_functionstructural constituent of ribosome
C0005737cellular_componentcytoplasm
C0005840cellular_componentribosome
C0006412biological_processtranslation
C0015935cellular_componentsmall ribosomal subunit
C0022627cellular_componentcytosolic small ribosomal subunit
C0030686cellular_component90S preribosome
C1990904cellular_componentribonucleoprotein complex
D0003723molecular_functionRNA binding
D0003735molecular_functionstructural constituent of ribosome
D0005634cellular_componentnucleus
D0005840cellular_componentribosome
D0006412biological_processtranslation
D0015935cellular_componentsmall ribosomal subunit
D0022627cellular_componentcytosolic small ribosomal subunit
D1990904cellular_componentribonucleoprotein complex
D2001235biological_processpositive regulation of apoptotic signaling pathway
E0003723molecular_functionRNA binding
E0003735molecular_functionstructural constituent of ribosome
E0005840cellular_componentribosome
E0006412biological_processtranslation
E0015935cellular_componentsmall ribosomal subunit
E0019843molecular_functionrRNA binding
E0022627cellular_componentcytosolic small ribosomal subunit
E0042274biological_processribosomal small subunit biogenesis
E0043226cellular_componentorganelle
E1990904cellular_componentribonucleoprotein complex
F0003723molecular_functionRNA binding
F0003735molecular_functionstructural constituent of ribosome
F0005840cellular_componentribosome
F0006412biological_processtranslation
F0015935cellular_componentsmall ribosomal subunit
F0019843molecular_functionrRNA binding
F0022627cellular_componentcytosolic small ribosomal subunit
F1990904cellular_componentribonucleoprotein complex
G0003723molecular_functionRNA binding
G0003735molecular_functionstructural constituent of ribosome
G0005840cellular_componentribosome
G0006412biological_processtranslation
G0015935cellular_componentsmall ribosomal subunit
G0022627cellular_componentcytosolic small ribosomal subunit
G1990904cellular_componentribonucleoprotein complex
H0003735molecular_functionstructural constituent of ribosome
H0005840cellular_componentribosome
H0006412biological_processtranslation
H0022627cellular_componentcytosolic small ribosomal subunit
H1990904cellular_componentribonucleoprotein complex
I0000028biological_processribosomal small subunit assembly
I0003723molecular_functionRNA binding
I0003729molecular_functionmRNA binding
I0003735molecular_functionstructural constituent of ribosome
I0005840cellular_componentribosome
I0006412biological_processtranslation
I0015935cellular_componentsmall ribosomal subunit
I0019843molecular_functionrRNA binding
I0022627cellular_componentcytosolic small ribosomal subunit
I1990904cellular_componentribonucleoprotein complex
J0003735molecular_functionstructural constituent of ribosome
J0005840cellular_componentribosome
J0006364biological_processrRNA processing
J0006412biological_processtranslation
J0022627cellular_componentcytosolic small ribosomal subunit
J0030686cellular_component90S preribosome
J0032040cellular_componentsmall-subunit processome
J0042274biological_processribosomal small subunit biogenesis
J1990904cellular_componentribonucleoprotein complex
K0003735molecular_functionstructural constituent of ribosome
K0005840cellular_componentribosome
K0006412biological_processtranslation
K0022627cellular_componentcytosolic small ribosomal subunit
K1990904cellular_componentribonucleoprotein complex
L0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L0003735molecular_functionstructural constituent of ribosome
L0005840cellular_componentribosome
L0006412biological_processtranslation
L0022627cellular_componentcytosolic small ribosomal subunit
L1990904cellular_componentribonucleoprotein complex
M0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M0003723molecular_functionRNA binding
M0003735molecular_functionstructural constituent of ribosome
M0005840cellular_componentribosome
M0006412biological_processtranslation
M0022627cellular_componentcytosolic small ribosomal subunit
M1990904cellular_componentribonucleoprotein complex
N0003735molecular_functionstructural constituent of ribosome
N0005840cellular_componentribosome
N0006412biological_processtranslation
N0015935cellular_componentsmall ribosomal subunit
N0022627cellular_componentcytosolic small ribosomal subunit
N1990904cellular_componentribonucleoprotein complex
O0003723molecular_functionRNA binding
O0003735molecular_functionstructural constituent of ribosome
O0005737cellular_componentcytoplasm
O0005840cellular_componentribosome
O0006412biological_processtranslation
O0022627cellular_componentcytosolic small ribosomal subunit
P0003735molecular_functionstructural constituent of ribosome
P0005840cellular_componentribosome
P0006412biological_processtranslation
Q0003735molecular_functionstructural constituent of ribosome
Q0005840cellular_componentribosome
Q0006412biological_processtranslation
Q0015935cellular_componentsmall ribosomal subunit
Q0022627cellular_componentcytosolic small ribosomal subunit
Q1990904cellular_componentribonucleoprotein complex
R0003735molecular_functionstructural constituent of ribosome
R0005737cellular_componentcytoplasm
R0005840cellular_componentribosome
R0006412biological_processtranslation
R0022627cellular_componentcytosolic small ribosomal subunit
R0042274biological_processribosomal small subunit biogenesis
R1990145biological_processmaintenance of translational fidelity
R1990904cellular_componentribonucleoprotein complex
S0003676molecular_functionnucleic acid binding
S0003723molecular_functionRNA binding
S0003735molecular_functionstructural constituent of ribosome
S0005829cellular_componentcytosol
S0005840cellular_componentribosome
S0006412biological_processtranslation
S0015935cellular_componentsmall ribosomal subunit
S1990904cellular_componentribonucleoprotein complex
T0002181biological_processcytoplasmic translation
T0003735molecular_functionstructural constituent of ribosome
T0005840cellular_componentribosome
T0006412biological_processtranslation
T0008270molecular_functionzinc ion binding
T0022627cellular_componentcytosolic small ribosomal subunit
T1990904cellular_componentribonucleoprotein complex
U0003735molecular_functionstructural constituent of ribosome
U0005730cellular_componentnucleolus
U0005840cellular_componentribosome
U0006412biological_processtranslation
U0022627cellular_componentcytosolic small ribosomal subunit
U0070181molecular_functionsmall ribosomal subunit rRNA binding
U1990904cellular_componentribonucleoprotein complex
V0003735molecular_functionstructural constituent of ribosome
V0005840cellular_componentribosome
V0006412biological_processtranslation
V0022627cellular_componentcytosolic small ribosomal subunit
V1990904cellular_componentribonucleoprotein complex
W0003735molecular_functionstructural constituent of ribosome
W0005739cellular_componentmitochondrion
W0005829cellular_componentcytosol
W0005840cellular_componentribosome
W0006412biological_processtranslation
W0022627cellular_componentcytosolic small ribosomal subunit
W1990904cellular_componentribonucleoprotein complex
X0000028biological_processribosomal small subunit assembly
X0003723molecular_functionRNA binding
X0003735molecular_functionstructural constituent of ribosome
X0005840cellular_componentribosome
X0006412biological_processtranslation
X0015935cellular_componentsmall ribosomal subunit
X0022627cellular_componentcytosolic small ribosomal subunit
X1990904cellular_componentribonucleoprotein complex
Y0000028biological_processribosomal small subunit assembly
Y0003723molecular_functionRNA binding
Y0003735molecular_functionstructural constituent of ribosome
Y0005840cellular_componentribosome
Y0006412biological_processtranslation
Y0022627cellular_componentcytosolic small ribosomal subunit
Y1990904cellular_componentribonucleoprotein complex
Z0000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z0000461biological_processendonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z0003735molecular_functionstructural constituent of ribosome
Z0005840cellular_componentribosome
Z0006412biological_processtranslation
Z0022627cellular_componentcytosolic small ribosomal subunit
Z1990904cellular_componentribonucleoprotein complex
a0003735molecular_functionstructural constituent of ribosome
a0005840cellular_componentribosome
a0006412biological_processtranslation
a0022627cellular_componentcytosolic small ribosomal subunit
a1990904cellular_componentribonucleoprotein complex
b0003735molecular_functionstructural constituent of ribosome
b0005840cellular_componentribosome
b0006412biological_processtranslation
b0022627cellular_componentcytosolic small ribosomal subunit
b1990904cellular_componentribonucleoprotein complex
c0003729molecular_functionmRNA binding
c0003735molecular_functionstructural constituent of ribosome
c0005840cellular_componentribosome
c0006412biological_processtranslation
c0022627cellular_componentcytosolic small ribosomal subunit
c1990904cellular_componentribonucleoprotein complex
d0000028biological_processribosomal small subunit assembly
d0003723molecular_functionRNA binding
d0003735molecular_functionstructural constituent of ribosome
d0005840cellular_componentribosome
d0006412biological_processtranslation
d0022627cellular_componentcytosolic small ribosomal subunit
e0000028biological_processribosomal small subunit assembly
e0003735molecular_functionstructural constituent of ribosome
e0005840cellular_componentribosome
e0006412biological_processtranslation
e0022627cellular_componentcytosolic small ribosomal subunit
e0030490biological_processmaturation of SSU-rRNA
e1990904cellular_componentribonucleoprotein complex
f0003735molecular_functionstructural constituent of ribosome
f0005737cellular_componentcytoplasm
f0005829cellular_componentcytosol
f0005840cellular_componentribosome
f0006412biological_processtranslation
f0022627cellular_componentcytosolic small ribosomal subunit
f1990904cellular_componentribonucleoprotein complex
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MG A 2101
ChainResidue
AG10
AA1930

site_idAC2
Number of Residues1
Detailsbinding site for residue MG A 2102
ChainResidue
AG16

site_idAC3
Number of Residues2
Detailsbinding site for residue MG A 2103
ChainResidue
AA102
AC367

site_idAC4
Number of Residues5
Detailsbinding site for residue MG A 2104
ChainResidue
AC367
AA102
AU103
AU104
AA366

site_idAC5
Number of Residues2
Detailsbinding site for residue MG A 2105
ChainResidue
AC49
AA431

site_idAC6
Number of Residues2
Detailsbinding site for residue MG A 2106
ChainResidue
AA452
AU454

site_idAC7
Number of Residues2
Detailsbinding site for residue MG A 2107
ChainResidue
AA60
AA459

site_idAC8
Number of Residues1
Detailsbinding site for residue MG A 2108
ChainResidue
AA87

site_idAC9
Number of Residues1
Detailsbinding site for residue MG A 2109
ChainResidue
AG97

site_idAD1
Number of Residues1
Detailsbinding site for residue MG A 2111
ChainResidue
AU408

site_idAD2
Number of Residues3
Detailsbinding site for residue MG A 2112
ChainResidue
AG328
AG343
AA347

site_idAD3
Number of Residues3
Detailsbinding site for residue MG A 2113
ChainResidue
AG42
AA43
AU100

site_idAD4
Number of Residues2
Detailsbinding site for residue MG A 2114
ChainResidue
AU44
AA47

site_idAD5
Number of Residues1
Detailsbinding site for residue MG A 2115
ChainResidue
AG435

site_idAD6
Number of Residues3
Detailsbinding site for residue MG A 2116
ChainResidue
AG383
AA384
AU385

site_idAD7
Number of Residues2
Detailsbinding site for residue MG A 2117
ChainResidue
AA407
AU408

site_idAD8
Number of Residues2
Detailsbinding site for residue MG A 2118
ChainResidue
AC430
AG432

site_idAD9
Number of Residues2
Detailsbinding site for residue MG A 2119
ChainResidue
AA466
AG467

site_idAE1
Number of Residues1
Detailsbinding site for residue MG A 2120
ChainResidue
AA28

site_idAE2
Number of Residues3
Detailsbinding site for residue MG A 2121
ChainResidue
AU35
AG522
AC537

site_idAE3
Number of Residues1
Detailsbinding site for residue MG A 2123
ChainResidue
AG568

site_idAE4
Number of Residues2
Detailsbinding site for residue MG A 2124
ChainResidue
AA577
AG578

site_idAE5
Number of Residues1
Detailsbinding site for residue MG A 2125
ChainResidue
AA611

site_idAE6
Number of Residues3
Detailsbinding site for residue MG A 2126
ChainResidue
AG377
AA612
AA614

site_idAE7
Number of Residues1
Detailsbinding site for residue MG A 2127
ChainResidue
AC621

site_idAE8
Number of Residues4
Detailsbinding site for residue MG A 2128
ChainResidue
AU625
AA626
AA627
AA628

site_idAE9
Number of Residues1
Detailsbinding site for residue MG A 2129
ChainResidue
AC630

site_idAF1
Number of Residues4
Detailsbinding site for residue MG A 2130
ChainResidue
AA629
AC630
AC632
AU1100

site_idAF2
Number of Residues2
Detailsbinding site for residue MG A 2131
ChainResidue
AA637
AG638

site_idAF3
Number of Residues2
Detailsbinding site for residue MG A 2132
ChainResidue
AA642
AA643

site_idAF4
Number of Residues2
Detailsbinding site for residue MG A 2133
ChainResidue
AA930
AA931

site_idAF5
Number of Residues1
Detailsbinding site for residue MG A 2135
ChainResidue
AG1007

site_idAF6
Number of Residues3
Detailsbinding site for residue MG A 2136
ChainResidue
AU1059
AG1060
AG1080

site_idAF7
Number of Residues1
Detailsbinding site for residue MG A 2137
ChainResidue
AU1081

site_idAF8
Number of Residues1
Detailsbinding site for residue MG A 2138
ChainResidue
AG1054

site_idAF9
Number of Residues5
Detailsbinding site for residue MG A 2139
ChainResidue
AG964
AU965
AG983
AA984
AU986

site_idAG1
Number of Residues2
Detailsbinding site for residue MG A 2140
ChainResidue
AG997
AA998

site_idAG2
Number of Residues1
Detailsbinding site for residue MG A 2141
ChainResidue
AG945

site_idAG3
Number of Residues2
Detailsbinding site for residue MG A 2142
ChainResidue
AG1011
cGLY16

site_idAG4
Number of Residues1
Detailsbinding site for residue MG A 2143
ChainResidue
AA1047

site_idAG5
Number of Residues1
Detailsbinding site for residue MG A 2144
ChainResidue
AU1037

site_idAG6
Number of Residues1
Detailsbinding site for residue MG A 2145
ChainResidue
AA1094

site_idAG7
Number of Residues2
Detailsbinding site for residue MG A 2146
ChainResidue
AG1210
AG1211

site_idAG8
Number of Residues3
Detailsbinding site for residue MG A 2147
ChainResidue
AA1261
AG1876
MTYR143

site_idAG9
Number of Residues3
Detailsbinding site for residue MG A 2148
ChainResidue
AG1926
AU1927
AG2085

site_idAH1
Number of Residues5
Detailsbinding site for residue MG A 2149
ChainResidue
AA2055
AG2059
AG2060
AU2062
AU2063

site_idAH2
Number of Residues1
Detailsbinding site for residue MG A 2150
ChainResidue
AU2062

site_idAH3
Number of Residues5
Detailsbinding site for residue MG A 2151
ChainResidue
AA2055
AG2059
AG2060
AU2053
AA2054

site_idAH4
Number of Residues2
Detailsbinding site for residue MG A 2152
ChainResidue
AG20
AU21

site_idAH5
Number of Residues1
Detailsbinding site for residue MG A 2153
ChainResidue
AG521

site_idAH6
Number of Residues2
Detailsbinding site for residue MG A 2154
ChainResidue
AU1405
AG1406

site_idAH7
Number of Residues2
Detailsbinding site for residue MG A 2155
ChainResidue
AA169
AC170

site_idAH8
Number of Residues2
Detailsbinding site for residue MG A 2156
ChainResidue
AG394
AU408

site_idAH9
Number of Residues5
Detailsbinding site for residue MG A 2157
ChainResidue
AG559
AG560
AC561
AA562
AA563

site_idAI1
Number of Residues3
Detailsbinding site for residue MG A 2158
ChainResidue
AA1062
AA1074
AMG2159

site_idAI2
Number of Residues3
Detailsbinding site for residue MG A 2159
ChainResidue
AG1063
AA1074
AMG2158

site_idAI3
Number of Residues1
Detailsbinding site for residue MG A 2160
ChainResidue
AU1084

site_idAI4
Number of Residues1
Detailsbinding site for residue MG A 2161
ChainResidue
AG1432

site_idAI5
Number of Residues2
Detailsbinding site for residue MG A 2162
ChainResidue
AG1430
AG1432

site_idAI6
Number of Residues4
Detailsbinding site for residue MG A 2163
ChainResidue
AG1374
AC1375
AG1674
AG1675

site_idAI7
Number of Residues4
Detailsbinding site for residue MG A 2164
ChainResidue
AA1305
AC1306
AU1307
AG1701

site_idAI8
Number of Residues3
Detailsbinding site for residue MG A 2165
ChainResidue
AA1303
AA1304
AC1896

site_idAI9
Number of Residues1
Detailsbinding site for residue MG A 2166
ChainResidue
AU1703

site_idAJ1
Number of Residues1
Detailsbinding site for residue MG A 2167
ChainResidue
AG1302

site_idAJ2
Number of Residues7
Detailsbinding site for residue 34G P 201
ChainResidue
AG973
AU1068
AC1075
AC1076
AG2060
AU2061
PLEU151

site_idAJ3
Number of Residues5
Detailsbinding site for residue ZN T 100
ChainResidue
TCYS19
TCYS22
TASN24
TCYS37
TCYS40

Functional Information from PROSITE/UniProt
site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. IaKMLICKVHIG
ChainResidueDetails
CILE14-GLY25

site_idPS00963
Number of Residues25
DetailsRIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLIVtDprtDaqsVkEsayaNIP
ChainResidueDetails
CPRO118-PRO142

site_idPS00529
Number of Residues23
DetailsRIBOSOMAL_S24E Ribosomal protein S24e signature. FGggRTkGFGlIYKNvdavkkfE
ChainResidueDetails
aPHE65-GLU87

site_idPS00056
Number of Residues13
DetailsRIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgQcRPLS
ChainResidueDetails
VGLY123-SER135

site_idPS00052
Number of Residues27
DetailsRIBOSOMAL_S7 Ribosomal protein S7 signature. ErLvnsMMmhgrnnGKKlkairIVayA
ChainResidueDetails
IGLU61-ALA87

site_idPS00632
Number of Residues25
DetailsRIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtkVFKlglAkSvhhARvLI
ChainResidueDetails
ELEU105-ILE129

site_idPS01189
Number of Residues19
DetailsRIBOSOMAL_S12E Ribosomal protein S12e signature. AIQkvIknAhvhDGLkiGI
ChainResidueDetails
RALA24-ILE42

site_idPS00171
Number of Residues11
DetailsTIM_1 Triosephosphate isomerase active site. VYEPLWLIGSG
ChainResidueDetails
MVAL49-GLY59

site_idPS00360
Number of Residues19
DetailsRIBOSOMAL_S9 Ribosomal protein S9 signature. GGGqtSQiyAirqAiGKGI
ChainResidueDetails
MGLY72-ILE90

site_idPS00323
Number of Residues25
DetailsRIBOSOMAL_S19 Ribosomal protein S19 signature. NGKqytnveIkpemIGyyLGEFsiT
ChainResidueDetails
XASN98-THR122

site_idPS00646
Number of Residues14
DetailsRIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHhwGlrVRGQ
ChainResidueDetails
SARG123-GLN136

site_idPS00053
Number of Residues18
DetailsRIBOSOMAL_S8 Ribosomal protein S8 signature. GhlILTTPyGIMdheeAR
ChainResidueDetails
KGLY100-ARG117

site_idPS00054
Number of Residues23
DetailsRIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GLkIgrieDvTPiPTD
ChainResidueDetails
PLEU116-ASP138

site_idPS00712
Number of Residues16
DetailsRIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKrMKNkVAGFvTH
ChainResidueDetails
WILE41-HIS56

site_idPS00961
Number of Residues9
DetailsRIBOSOMAL_S28E Ribosomal protein S28e signature. ETEREARrL
ChainResidueDetails
eGLU58-LEU66

site_idPS00528
Number of Residues15
DetailsRIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVNaPshWmLnK
ChainResidueDetails
FHIS8-LYS22

site_idPS00055
Number of Residues8
DetailsRIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAyR
ChainResidueDetails
QLYS62-ARG69

site_idPS00527
Number of Residues23
DetailsRIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsnkhaiirkyn.INICRqCFR
ChainResidueDetails
TARG20-ARG42

site_idPS00733
Number of Residues8
DetailsRIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH
ChainResidueDetails
cTYR73-HIS80

site_idPS00628
Number of Residues20
DetailsRIBOSOMAL_S19E Ribosomal protein S19e signature. PnhtslaSgkIlRsILQqLE
ChainResidueDetails
YPRO112-GLU131

site_idPS00578
Number of Residues12
DetailsRIBOSOMAL_S6E Ribosomal protein S6e signature. ITGGnDkqGfPM
ChainResidueDetails
HILE52-MET63

217705

数据于2024-03-27公开中

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