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6OJV

Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0000900molecular_functionmRNA regulatory element binding translation repressor activity
A0003729molecular_functionmRNA binding
A0004146molecular_functiondihydrofolate reductase activity
A0004799molecular_functionthymidylate synthase activity
A0005542molecular_functionfolic acid binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006206biological_processpyrimidine nucleobase metabolic process
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0006417biological_processregulation of translation
A0007623biological_processcircadian rhythm
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0017148biological_processnegative regulation of translation
A0019860biological_processuracil metabolic process
A0032259biological_processmethylation
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0035999biological_processtetrahydrofolate interconversion
A0042803molecular_functionprotein homodimerization activity
A0045471biological_processresponse to ethanol
A0046653biological_processtetrahydrofolate metabolic process
A0046683biological_processresponse to organophosphorus
A0048589biological_processdevelopmental growth
A0051216biological_processcartilage development
A0051384biological_processresponse to glucocorticoid
A0051593biological_processresponse to folic acid
A0060574biological_processintestinal epithelial cell maturation
A0071897biological_processDNA biosynthetic process
A0097421biological_processliver regeneration
A1901363molecular_functionheterocyclic compound binding
A1990825molecular_functionsequence-specific mRNA binding
B0000900molecular_functionmRNA regulatory element binding translation repressor activity
B0003729molecular_functionmRNA binding
B0004146molecular_functiondihydrofolate reductase activity
B0004799molecular_functionthymidylate synthase activity
B0005542molecular_functionfolic acid binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006206biological_processpyrimidine nucleobase metabolic process
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0006417biological_processregulation of translation
B0007623biological_processcircadian rhythm
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0017148biological_processnegative regulation of translation
B0019860biological_processuracil metabolic process
B0032259biological_processmethylation
B0032570biological_processresponse to progesterone
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0035999biological_processtetrahydrofolate interconversion
B0042803molecular_functionprotein homodimerization activity
B0045471biological_processresponse to ethanol
B0046653biological_processtetrahydrofolate metabolic process
B0046683biological_processresponse to organophosphorus
B0048589biological_processdevelopmental growth
B0051216biological_processcartilage development
B0051384biological_processresponse to glucocorticoid
B0051593biological_processresponse to folic acid
B0060574biological_processintestinal epithelial cell maturation
B0071897biological_processDNA biosynthetic process
B0097421biological_processliver regeneration
B1901363molecular_functionheterocyclic compound binding
B1990825molecular_functionsequence-specific mRNA binding
C0000900molecular_functionmRNA regulatory element binding translation repressor activity
C0003729molecular_functionmRNA binding
C0004146molecular_functiondihydrofolate reductase activity
C0004799molecular_functionthymidylate synthase activity
C0005542molecular_functionfolic acid binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006206biological_processpyrimidine nucleobase metabolic process
C0006231biological_processdTMP biosynthetic process
C0006235biological_processdTTP biosynthetic process
C0006417biological_processregulation of translation
C0007623biological_processcircadian rhythm
C0008168molecular_functionmethyltransferase activity
C0009165biological_processnucleotide biosynthetic process
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016741molecular_functiontransferase activity, transferring one-carbon groups
C0017148biological_processnegative regulation of translation
C0019860biological_processuracil metabolic process
C0032259biological_processmethylation
C0032570biological_processresponse to progesterone
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0035999biological_processtetrahydrofolate interconversion
C0042803molecular_functionprotein homodimerization activity
C0045471biological_processresponse to ethanol
C0046653biological_processtetrahydrofolate metabolic process
C0046683biological_processresponse to organophosphorus
C0048589biological_processdevelopmental growth
C0051216biological_processcartilage development
C0051384biological_processresponse to glucocorticoid
C0051593biological_processresponse to folic acid
C0060574biological_processintestinal epithelial cell maturation
C0071897biological_processDNA biosynthetic process
C0097421biological_processliver regeneration
C1901363molecular_functionheterocyclic compound binding
C1990825molecular_functionsequence-specific mRNA binding
D0000900molecular_functionmRNA regulatory element binding translation repressor activity
D0003729molecular_functionmRNA binding
D0004146molecular_functiondihydrofolate reductase activity
D0004799molecular_functionthymidylate synthase activity
D0005542molecular_functionfolic acid binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006206biological_processpyrimidine nucleobase metabolic process
D0006231biological_processdTMP biosynthetic process
D0006235biological_processdTTP biosynthetic process
D0006417biological_processregulation of translation
D0007623biological_processcircadian rhythm
D0008168molecular_functionmethyltransferase activity
D0009165biological_processnucleotide biosynthetic process
D0009410biological_processresponse to xenobiotic stimulus
D0009636biological_processresponse to toxic substance
D0014070biological_processresponse to organic cyclic compound
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016741molecular_functiontransferase activity, transferring one-carbon groups
D0017148biological_processnegative regulation of translation
D0019860biological_processuracil metabolic process
D0032259biological_processmethylation
D0032570biological_processresponse to progesterone
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0035999biological_processtetrahydrofolate interconversion
D0042803molecular_functionprotein homodimerization activity
D0045471biological_processresponse to ethanol
D0046653biological_processtetrahydrofolate metabolic process
D0046683biological_processresponse to organophosphorus
D0048589biological_processdevelopmental growth
D0051216biological_processcartilage development
D0051384biological_processresponse to glucocorticoid
D0051593biological_processresponse to folic acid
D0060574biological_processintestinal epithelial cell maturation
D0071897biological_processDNA biosynthetic process
D0097421biological_processliver regeneration
D1901363molecular_functionheterocyclic compound binding
D1990825molecular_functionsequence-specific mRNA binding
PDBデータベースに由来する情報
site_idAC1
残基数12
詳細binding site for residue UMP B 600
鎖名残基
BARG50
BHIS256
BTYR258
B2XB601
BCYS195
BHIS196
BGLN214
BARG215
BSER216
BGLY217
BASP218
BASN226

site_idAC2
残基数11
詳細binding site for residue 2XB B 601
鎖名残基
BILE108
BASN112
BLEU192
BASP218
BLEU221
BGLY222
BPHE225
BTYR258
BMET311
BALA312
BUMP600

site_idAC3
残基数15
詳細binding site for residue UMP A 600
鎖名残基
AARG50
ACYS195
AHIS196
AGLN214
AARG215
ASER216
AGLY217
AASP218
AASN226
AHIS256
ATYR258
A2XB601
DARG175
DARG176
DHOH705

site_idAC4
残基数10
詳細binding site for residue 2XB A 601
鎖名残基
AILE108
ATRP109
AASN112
ALEU192
AASP218
AGLY222
ATYR258
AMET311
AALA312
AUMP600

site_idAC5
残基数13
詳細binding site for residue UMP C 600
鎖名残基
CARG50
CLEU192
CCYS195
CHIS196
CGLN214
CARG215
CSER216
CGLY217
CASP218
CASN226
CHIS256
CTYR258
C2XB601

site_idAC6
残基数9
詳細binding site for residue 2XB C 601
鎖名残基
CILE108
CASN112
CASP218
CLEU221
CGLY222
CTYR258
CMET311
CALA312
CUMP600

site_idAC7
残基数13
詳細binding site for residue UMP D 600
鎖名残基
AARG175
AARG176
DARG50
DCYS195
DHIS196
DGLN214
DARG215
DSER216
DASP218
DASN226
DHIS256
DTYR258
D2XB601

site_idAC8
残基数10
詳細binding site for residue 2XB D 601
鎖名残基
DLYS77
DPHE80
DILE108
DASN112
DASP218
DGLY222
DPHE225
DMET311
DALA312
DUMP600

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00091
残基数29
詳細THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNprdlplma.....LpPCHalcQFyV
鎖名残基詳細
BARG175-VAL203

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数4
詳細ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884
鎖名残基詳細
BCYS195
ACYS195
CCYS195
DCYS195

site_idSWS_FT_FI2
残基数8
詳細BINDING: in other chain => ECO:0000250|UniProtKB:P0A884
鎖名残基詳細
BARG50
BASN226
AARG50
AASN226
CARG50
CASN226
DARG50
DASN226

site_idSWS_FT_FI3
残基数4
詳細BINDING: BINDING => ECO:0000250|UniProtKB:P45352
鎖名残基詳細
BARG175
AARG175
CARG175
DARG175

site_idSWS_FT_FI4
残基数12
詳細BINDING: in other chain => ECO:0000250|UniProtKB:P45352
鎖名残基詳細
BCYS195
DCYS195
DARG215
DHIS256
BARG215
BHIS256
ACYS195
AARG215
AHIS256
CCYS195
CARG215
CHIS256

site_idSWS_FT_FI5
残基数8
詳細BINDING: BINDING => ECO:0000250|UniProtKB:P0A884
鎖名残基詳細
BASP218
BALA312
AASP218
AALA312
CASP218
CALA312
DASP218
DALA312

site_idSWS_FT_FI6
残基数4
詳細MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
鎖名残基詳細
BSER114
ASER114
CSER114
DSER114

site_idSWS_FT_FI7
残基数16
詳細CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
鎖名残基詳細
BLYS287
CLYS292
CLYS308
DLYS287
DLYS292
DLYS308
BLYS292
BLYS308
ALYS287
ALYS292
ALYS308
CLYS287

218853

件を2024-04-24に公開中

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