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6O4W

Binary complex of native hAChE with Donepezil

Functional Information from GO Data
ChainGOidnamespacecontents
A0001507biological_processacetylcholine catabolic process in synaptic cleft
A0001540molecular_functionamyloid-beta binding
A0001919biological_processregulation of receptor recycling
A0002076biological_processosteoblast development
A0003990molecular_functionacetylcholinesterase activity
A0004104molecular_functioncholinesterase activity
A0005515molecular_functionprotein binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005604cellular_componentbasement membrane
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006581biological_processacetylcholine catabolic process
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0007416biological_processsynapse assembly
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017171molecular_functionserine hydrolase activity
A0019695biological_processcholine metabolic process
A0031594cellular_componentneuromuscular junction
A0031623biological_processreceptor internalization
A0032223biological_processnegative regulation of synaptic transmission, cholinergic
A0042166molecular_functionacetylcholine binding
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042982biological_processamyloid precursor protein metabolic process
A0043083cellular_componentsynaptic cleft
A0043236molecular_functionlaminin binding
A0043621molecular_functionobsolete protein self-association
A0045202cellular_componentsynapse
A0048471cellular_componentperinuclear region of cytoplasm
A0050714biological_processpositive regulation of protein secretion
A0052689molecular_functioncarboxylic ester hydrolase activity
A0060041biological_processretina development in camera-type eye
A0095500biological_processacetylcholine receptor signaling pathway
A0098552cellular_componentside of membrane
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001507biological_processacetylcholine catabolic process in synaptic cleft
B0001540molecular_functionamyloid-beta binding
B0001919biological_processregulation of receptor recycling
B0002076biological_processosteoblast development
B0003990molecular_functionacetylcholinesterase activity
B0004104molecular_functioncholinesterase activity
B0005515molecular_functionprotein binding
B0005518molecular_functioncollagen binding
B0005576cellular_componentextracellular region
B0005604cellular_componentbasement membrane
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006581biological_processacetylcholine catabolic process
B0007155biological_processcell adhesion
B0007399biological_processnervous system development
B0007416biological_processsynapse assembly
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017171molecular_functionserine hydrolase activity
B0019695biological_processcholine metabolic process
B0031594cellular_componentneuromuscular junction
B0031623biological_processreceptor internalization
B0032223biological_processnegative regulation of synaptic transmission, cholinergic
B0042166molecular_functionacetylcholine binding
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042982biological_processamyloid precursor protein metabolic process
B0043083cellular_componentsynaptic cleft
B0043236molecular_functionlaminin binding
B0043621molecular_functionobsolete protein self-association
B0045202cellular_componentsynapse
B0048471cellular_componentperinuclear region of cytoplasm
B0050714biological_processpositive regulation of protein secretion
B0052689molecular_functioncarboxylic ester hydrolase activity
B0060041biological_processretina development in camera-type eye
B0095500biological_processacetylcholine receptor signaling pathway
B0098552cellular_componentside of membrane
B0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue GOL A 601
ChainResidue
AGLU81
AMET85
ATHR436
ALEU437
ASER438
ATYR449
AGLU452
AHOH842

site_idAC2
Number of Residues4
Detailsbinding site for residue GOL A 602
ChainResidue
AE20604
AHOH718
AHOH788
ATYR341

site_idAC3
Number of Residues5
Detailsbinding site for residue GOL A 603
ChainResidue
AARG46
AARG274
ATHR275
APRO277
AHOH833

site_idAC4
Number of Residues13
Detailsbinding site for residue E20 A 604
ChainResidue
ATYR72
ATRP86
ATYR124
AGLU202
ATRP286
ASER293
APHE295
ATYR337
APHE338
ATYR341
AGOL602
AHOH708
AHOH832

site_idAC5
Number of Residues3
Detailsbinding site for residue NO3 A 605
ChainResidue
AASP333
ATRP442
AHOH755

site_idAC6
Number of Residues8
Detailsbinding site for residue GOL B 601
ChainResidue
BGLU81
BMET85
BTHR436
BLEU437
BSER438
BTYR449
BGLU452
BHOH846

site_idAC7
Number of Residues6
Detailsbinding site for residue GOL B 602
ChainResidue
BLEU76
BTYR341
BE20604
BHOH712
BHOH789
BHOH811

site_idAC8
Number of Residues3
Detailsbinding site for residue GOL B 603
ChainResidue
BARG274
BPRO277
BHOH755

site_idAC9
Number of Residues13
Detailsbinding site for residue E20 B 604
ChainResidue
BTYR72
BTRP86
BTYR124
BGLU202
BTRP286
BSER293
BPHE295
BTYR337
BPHE338
BTYR341
BGOL602
BHOH701
BHOH847

site_idAD1
Number of Residues4
Detailsbinding site for residue NO3 B 605
ChainResidue
BLYS332
BASP333
BGLU396
BTRP442

site_idAD2
Number of Residues2
Detailsbinding site for residue NO3 B 606
ChainResidue
BPRO36
BTYR98

site_idAD3
Number of Residues4
Detailsbinding site for residue NO3 B 607
ChainResidue
BPRO88
BASN89
BARG90
BGLU91

Functional Information from PROSITE/UniProt
site_idPS00122
Number of Residues16
DetailsCARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdptsVtLfGeSAG
ChainResidueDetails
APHE190-GLY205

site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP
ChainResidueDetails
AGLU94-PRO104

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Acyl-ester intermediate
ChainResidueDetails
ASER203
BSER203

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AGLU334
AHIS447
BGLU334
BHIS447

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:4EY5
ChainResidueDetails
ATRP86
ATYR133
ATYR337
BTRP86
BTYR133
BTYR337

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:4BDT
ChainResidueDetails
ATRP439
AHIS447
BGLY122
BSER203
BTRP439
BHIS447
AGLY122
ASER203

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:4EY6
ChainResidueDetails
AGLU202
BGLU202

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7
ChainResidueDetails
AASN265
BASN265

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11053835, ECO:0000269|PubMed:20408548, ECO:0000269|PubMed:23035744, ECO:0000269|PubMed:23679855, ECO:0007744|PDB:1B41, ECO:0007744|PDB:1F8U, ECO:0007744|PDB:2X8B, ECO:0007744|PDB:4BDT, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7, ECO:0007744|PDB:4EY8
ChainResidueDetails
AASN350
BASN350

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY8
ChainResidueDetails
AASN464
BASN464

218500

건을2024-04-17부터공개중

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