6NKJ
1.3 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with (2R)-2-(phosphonooxy)propanoic acid.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007049 | biological_process | cell cycle |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0008760 | molecular_function | UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019277 | biological_process | UDP-N-acetylgalactosamine biosynthetic process |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0007049 | biological_process | cell cycle |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0008760 | molecular_function | UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019277 | biological_process | UDP-N-acetylgalactosamine biosynthetic process |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 0V5 A 501 |
| Chain | Residue |
| A | ARG96 |
| A | CYS120 |
| A | THR121 |
| A | ARG401 |
| A | CIT502 |
| A | HOH609 |
| A | HOH642 |
| A | HOH679 |
| A | HOH790 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue CIT A 502 |
| Chain | Residue |
| A | LYS23 |
| A | ASN24 |
| A | ILE122 |
| A | ARG125 |
| A | ASP309 |
| A | ARG335 |
| A | LEU374 |
| A | ARG375 |
| A | ARG401 |
| A | 0V5501 |
| A | HOH636 |
| A | HOH647 |
| A | HOH652 |
| A | HOH670 |
| A | HOH736 |
| A | HOH742 |
| A | HOH865 |
| A | HOH1066 |
| A | HOH1154 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | SER115 |
| A | GLY146 |
| A | TYR147 |
| B | ARG344 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | HIS226 |
| B | LYS299 |
| B | HOH908 |
| B | HOH952 |
| B | HOH1058 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | binding site for residue CIT B 503 |
| Chain | Residue |
| B | LYS23 |
| B | ASN24 |
| B | ILE122 |
| B | ARG125 |
| B | ASP309 |
| B | PHE332 |
| B | ARG335 |
| B | LEU374 |
| B | ARG375 |
| B | ARG401 |
| B | 0V5501 |
| B | HOH633 |
| B | HOH638 |
| B | HOH665 |
| B | HOH705 |
| B | HOH716 |
| B | HOH746 |
| B | HOH774 |
| B | HOH779 |
| B | HOH827 |
| B | HOH912 |
| B | HOH927 |
| B | HOH1039 |
| B | HOH1091 |
| B | HOH1169 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | ASN203 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide 0V5 B 501 and CYS B 120 |
| Chain | Residue |
| A | GLU340 |
| A | HOH646 |
| B | ARG96 |
| B | GLY119 |
| B | THR121 |
| B | ILE122 |
| B | GLY123 |
| B | ARG125 |
| B | ARG401 |
| B | CIT503 |
| B | HOH674 |
| B | HOH679 |
| B | HOH686 |
| B | HOH776 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00111 |
| Chain | Residue | Details |
| A | CYS120 | |
| B | CYS120 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00111 |
| Chain | Residue | Details |
| A | LYS23 | |
| B | VAL331 | |
| A | ARG96 | |
| A | ARG125 | |
| A | ASP309 | |
| A | VAL331 | |
| B | LYS23 | |
| B | ARG96 | |
| B | ARG125 | |
| B | ASP309 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: 2-(S-cysteinyl)pyruvic acid O-phosphothioketal => ECO:0000255|HAMAP-Rule:MF_00111 |
| Chain | Residue | Details |
| A | CYS120 | |
| B | CYS120 |
