Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6N3P

Crosslinked AcpP=FabZ complex from E. coli Type II FAS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
A	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
A	0009245	biological_process	lipid A biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0042802	molecular_function	identical protein binding
A	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
A	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
B	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
B	0009245	biological_process	lipid A biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0042802	molecular_function	identical protein binding
B	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
B	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
C	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
C	0009245	biological_process	lipid A biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0042802	molecular_function	identical protein binding
C	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
C	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
D	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
D	0009245	biological_process	lipid A biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0042802	molecular_function	identical protein binding
D	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
D	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0006629	biological_process	lipid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
E	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
E	0009245	biological_process	lipid A biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0042802	molecular_function	identical protein binding
E	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
E	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0006629	biological_process	lipid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0008659	molecular_function	(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
F	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
F	0009245	biological_process	lipid A biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0042802	molecular_function	identical protein binding
F	0047450	molecular_function	(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity
F	0047451	molecular_function	(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G	0000035	molecular_function	acyl binding
G	0000036	molecular_function	acyl carrier activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0008289	molecular_function	lipid binding
G	0008610	biological_process	lipid biosynthetic process
G	0009245	biological_process	lipid A biosynthetic process
G	0009410	biological_process	response to xenobiotic stimulus
G	0031177	molecular_function	phosphopantetheine binding
H	0000035	molecular_function	acyl binding
H	0000036	molecular_function	acyl carrier activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0008289	molecular_function	lipid binding
H	0008610	biological_process	lipid biosynthetic process
H	0009245	biological_process	lipid A biosynthetic process
H	0009410	biological_process	response to xenobiotic stimulus
H	0031177	molecular_function	phosphopantetheine binding
I	0000035	molecular_function	acyl binding
I	0000036	molecular_function	acyl carrier activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0008289	molecular_function	lipid binding
I	0008610	biological_process	lipid biosynthetic process
I	0009245	biological_process	lipid A biosynthetic process
I	0009410	biological_process	response to xenobiotic stimulus
I	0031177	molecular_function	phosphopantetheine binding
J	0000035	molecular_function	acyl binding
J	0000036	molecular_function	acyl carrier activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0008289	molecular_function	lipid binding
J	0008610	biological_process	lipid biosynthetic process
J	0009245	biological_process	lipid A biosynthetic process
J	0009410	biological_process	response to xenobiotic stimulus
J	0031177	molecular_function	phosphopantetheine binding
K	0000035	molecular_function	acyl binding
K	0000036	molecular_function	acyl carrier activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0006633	biological_process	fatty acid biosynthetic process
K	0008289	molecular_function	lipid binding
K	0008610	biological_process	lipid biosynthetic process
K	0009245	biological_process	lipid A biosynthetic process
K	0009410	biological_process	response to xenobiotic stimulus
K	0031177	molecular_function	phosphopantetheine binding
L	0000035	molecular_function	acyl binding
L	0000036	molecular_function	acyl carrier activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006629	biological_process	lipid metabolic process
L	0006631	biological_process	fatty acid metabolic process
L	0006633	biological_process	fatty acid biosynthetic process
L	0008289	molecular_function	lipid binding
L	0008610	biological_process	lipid biosynthetic process
L	0009245	biological_process	lipid A biosynthetic process
L	0009410	biological_process	response to xenobiotic stimulus
L	0031177	molecular_function	phosphopantetheine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for Di-peptide XLN A 400 and SER I 36

Chain	Residue
A	GLU33
A	LYS102
A	ARG103
A	PRO104
A	THR116
A	PHE117
B	HIS19
B	GLU68
B	TYR91
B	TYR92
B	PHE93
A	GLU34
B	LEU124
B	ALA146
I	ASP35
I	LEU37
I	ASP38
I	VAL40
J	ASN24
J	ASN25
A	GLY35
A	PHE37
A	HIS54
A	PHE55
A	PHE61
A	GLY63
A	PHE101

site_id	AC2
Number of Residues	27
Details	binding site for Di-peptide XLN A 400 and SER I 36

Chain	Residue
A	GLU33
A	GLU34
A	GLY35
A	PHE37
A	HIS54
A	PHE55
A	PHE61
A	GLY63
A	PHE101
A	LYS102
A	ARG103
A	PRO104
A	THR116
A	PHE117
B	HIS19
B	GLU68
B	TYR91
B	TYR92
B	PHE93
B	LEU124
B	ALA146
I	ASP35
I	LEU37
I	ASP38
I	VAL40
J	ASN24
J	ASN25

site_id	AC3
Number of Residues	23
Details	binding site for Di-peptide XLN B 400 and SER K 36

Chain	Residue
A	GLU68
A	TYR91
A	TYR92
A	PHE93
A	HOH503
B	GLU33
B	GLU34
B	GLY35
B	PHE37
B	HIS54
B	PHE55
B	PHE61
B	PRO62
B	GLY63
B	PHE101
B	LYS102
B	PRO104
B	THR116
B	PHE117
H	ASP70
K	ASP35
K	LEU37
K	ASP38

site_id	AC4
Number of Residues	23
Details	binding site for Di-peptide XLN B 400 and SER K 36

Chain	Residue
K	ASP38
A	GLU68
A	TYR91
A	TYR92
A	PHE93
A	HOH503
B	GLU33
B	GLU34
B	GLY35
B	PHE37
B	HIS54
B	PHE55
B	PHE61
B	PRO62
B	GLY63
B	PHE101
B	LYS102
B	PRO104
B	THR116
B	PHE117
H	ASP70
K	ASP35
K	LEU37

site_id	AC5
Number of Residues	19
Details	binding site for Di-peptide XLN C 400 and HIS C 54

Chain	Residue
C	PHE50
C	GLY53
C	PHE55
C	PRO56
C	ILE60
C	PHE61
C	PRO62
C	GLY63
C	PHE101
C	LYS102
C	PRO104
C	HOH502
D	HIS19
D	GLU68
D	TYR91
D	TYR92
D	PHE93
L	SER36
L	LEU37

site_id	AC6
Number of Residues	19
Details	binding site for Di-peptide XLN C 400 and HIS C 54

Chain	Residue
C	PHE50
C	GLY53
C	PHE55
C	PRO56
C	ILE60
C	PHE61
C	PRO62
C	GLY63
C	PHE101
C	LYS102
C	PRO104
C	HOH502
D	HIS19
D	GLU68
D	TYR91
D	TYR92
D	PHE93
L	SER36
L	LEU37

site_id	AC7
Number of Residues	26
Details	binding site for Di-peptide XLN C 400 and SER L 36

Chain	Residue
C	GLU33
C	GLU34
C	GLY35
C	PHE37
C	HIS54
C	PHE55
C	PHE61
C	PRO62
C	GLY63
C	PHE101
C	LYS102
C	PRO104
C	THR116
C	PHE117
C	HOH502
D	HIS19
D	GLU68
D	TYR91
D	TYR92
D	PHE93
L	ASP35
L	LEU37
L	ASP38
L	THR39
L	VAL40
L	GLN66

site_id	AC8
Number of Residues	26
Details	binding site for Di-peptide XLN C 400 and SER L 36

Chain	Residue
C	GLU33
C	GLU34
C	GLY35
C	PHE37
C	HIS54
C	PHE55
C	PHE61
C	PRO62
C	GLY63
C	PHE101
C	LYS102
C	PRO104
C	THR116
C	PHE117
C	HOH502
D	HIS19
D	GLU68
D	TYR91
D	TYR92
D	PHE93
L	ASP35
L	LEU37
L	ASP38
L	THR39
L	VAL40
L	GLN66

site_id	AC9
Number of Residues	25
Details	binding site for Di-peptide XLN D 400 and SER H 36

Chain	Residue
C	HIS19
C	GLU68
C	TYR91
C	TYR92
C	PHE93
D	GLU33
D	GLU34
D	GLY35
D	PHE37
D	HIS54
D	PHE55
D	PHE61
D	PRO62
D	GLY63
D	PHE101
D	LYS102
D	ARG103
D	PRO104
D	THR116
D	PHE117
H	ASP35
H	LEU37
H	ASP38
H	THR39
H	VAL40

site_id	AD1
Number of Residues	25
Details	binding site for Di-peptide XLN D 400 and SER H 36

Chain	Residue
C	HIS19
C	GLU68
C	TYR91
C	TYR92
C	PHE93
D	GLU33
D	GLU34
D	GLY35
D	PHE37
D	HIS54
D	PHE55
D	PHE61
D	PRO62
D	GLY63
D	PHE101
D	LYS102
D	ARG103
D	PRO104
D	THR116
D	PHE117
H	ASP35
H	LEU37
H	ASP38
H	THR39
H	VAL40

site_id	AD2
Number of Residues	19
Details	binding site for Di-peptide XLN D 400 and HIS D 54

Chain	Residue
C	HIS19
C	PHE23
C	GLU68
C	TYR91
C	TYR92
C	PHE93
D	PHE50
D	GLY53
D	PHE55
D	PRO56
D	ILE60
D	PHE61
D	PRO62
D	GLY63
D	PHE101
D	LYS102
D	ARG103
D	PRO104
H	SER36

site_id	AD3
Number of Residues	19
Details	binding site for Di-peptide XLN D 400 and HIS D 54

Chain	Residue
C	HIS19
C	PHE23
C	GLU68
C	TYR91
C	TYR92
C	PHE93
D	PHE50
D	GLY53
D	PHE55
D	PRO56
D	ILE60
D	PHE61
D	PRO62
D	GLY63
D	PHE101
D	LYS102
D	ARG103
D	PRO104
H	SER36

site_id	AD4
Number of Residues	30
Details	binding site for Di-peptide XLN E 400 and SER G 36

Chain	Residue
E	GLU33
E	GLU34
E	GLY35
E	PHE37
E	HIS54
E	PRO62
E	GLY63
E	PHE101
E	LYS102
E	ARG103
E	PRO104
E	THR116
E	PHE117
E	HOH507
F	HIS19
F	GLU68
F	TYR91
F	TYR92
F	PHE93
F	ARG122
G	ASP35
G	LEU37
G	ASP38
G	THR39
G	VAL40
I	LYS61
I	THR63
I	THR64
I	ALA67
K	ALA0

site_id	AD5
Number of Residues	30
Details	binding site for Di-peptide XLN E 400 and SER G 36

Chain	Residue
E	GLU33
E	GLU34
E	GLY35
E	PHE37
E	HIS54
E	PRO62
E	GLY63
E	PHE101
E	LYS102
E	ARG103
E	PRO104
E	THR116
E	PHE117
E	HOH507
F	HIS19
F	GLU68
F	TYR91
F	TYR92
F	PHE93
F	ARG122
G	ASP35
G	LEU37
G	ASP38
G	THR39
G	VAL40
I	LYS61
I	THR63
I	THR64
I	ALA67
K	ALA0

site_id	AD6
Number of Residues	21
Details	binding site for Di-peptide XLN E 400 and HIS E 54

Chain	Residue
E	PHE50
E	GLY53
E	PHE55
E	PRO56
E	ILE60
E	PRO62
E	GLY63
E	PHE101
E	LYS102
E	ARG103
E	PRO104
E	HOH507
F	HIS19
F	PHE23
F	GLU68
F	TYR91
F	TYR92
F	PHE93
F	ARG122
G	SER36
K	ALA0

site_id	AD7
Number of Residues	21
Details	binding site for Di-peptide XLN E 400 and HIS E 54

Chain	Residue
E	PHE50
E	GLY53
E	PHE55
E	PRO56
E	ILE60
E	PRO62
E	GLY63
E	PHE101
E	LYS102
E	ARG103
E	PRO104
E	HOH507
F	HIS19
F	PHE23
F	GLU68
F	TYR91
F	TYR92
F	PHE93
F	ARG122
G	SER36
K	ALA0

site_id	AD8
Number of Residues	22
Details	binding site for Di-peptide XLN F 400 and SER J 36

Chain	Residue
E	HIS19
E	GLU68
E	TYR91
E	TYR92
E	PHE93
E	SER148
E	GLU150
F	GLU33
F	GLU34
F	GLY35
F	PHE37
F	HIS54
F	PHE55
F	ILE60
F	GLY63
F	ARG103
F	PRO104
F	THR116
F	PHE117
J	ASP35
J	LEU37
J	HOH501

site_id	AD9
Number of Residues	18
Details	binding site for Di-peptide XLN F 400 and HIS F 54

Chain	Residue
E	HIS19
E	GLU68
E	TYR91
E	TYR92
E	PHE93
E	SER148
E	GLU150
F	PHE50
F	GLY53
F	PHE55
F	PRO56
F	ILE60
F	GLY63
F	ARG103
F	PRO104
J	ASP35
J	SER36
J	HOH501

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL

Chain	Residue	Details
G	ASP31-LEU46

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255\|PROSITE-ProRule:PRU00258, ECO:0000269\|PubMed:4882207

Chain	Residue	Details
G	SER36
H	SER36
I	SER36
J	SER36
K	SER36
L	SER36

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)