6MSO

Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0003824	molecular_function	catalytic activity
A	0004333	molecular_function	fumarate hydratase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006099	biological_process	tricarboxylic acid cycle
A	0006106	biological_process	fumarate metabolic process
A	0006108	biological_process	malate metabolic process
A	0008152	biological_process	metabolic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0003824	molecular_function	catalytic activity
B	0004333	molecular_function	fumarate hydratase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006091	biological_process	generation of precursor metabolites and energy
B	0006099	biological_process	tricarboxylic acid cycle
B	0006106	biological_process	fumarate metabolic process
B	0006108	biological_process	malate metabolic process
B	0008152	biological_process	metabolic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0003824	molecular_function	catalytic activity
C	0004333	molecular_function	fumarate hydratase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006099	biological_process	tricarboxylic acid cycle
C	0006106	biological_process	fumarate metabolic process
C	0006108	biological_process	malate metabolic process
C	0008152	biological_process	metabolic process
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0003824	molecular_function	catalytic activity
D	0004333	molecular_function	fumarate hydratase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006099	biological_process	tricarboxylic acid cycle
D	0006106	biological_process	fumarate metabolic process
D	0006108	biological_process	malate metabolic process
D	0008152	biological_process	metabolic process
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding

PDBデータベースに由来する情報

site_id	AC1
残基数	8
詳細	binding site for residue SF4 A 601

鎖名	残基
A	CYS114
A	GLN115
A	GLY195
A	CYS233
A	CYS328
A	ALA330
A	LYS474
A	JYD608

site_id	AC2
残基数	3
詳細	binding site for residue GOL A 602

鎖名	残基
A	TYR28
A	LYS337
A	HIS23

site_id	AC3
残基数	3
詳細	binding site for residue GOL A 603

鎖名	残基
A	LYS288
A	GLN291
A	LYS302

site_id	AC4
残基数	2
詳細	binding site for residue GOL A 604

鎖名	残基
A	LYS150
A	ARG151

site_id	AC5
残基数	4
詳細	binding site for residue GOL A 605

鎖名	残基
A	ARG278
A	ASP307
A	ARG309
A	HOH890

site_id	AC6
残基数	2
詳細	binding site for residue GOL A 606

鎖名	残基
A	GLN438
A	HOH878

site_id	AC7
残基数	4
詳細	binding site for residue 1PE A 607

鎖名	残基
A	LEU30
A	LYS33
A	ASP341
A	TRP344

site_id	AC8
残基数	12
詳細	binding site for residue JYD A 608

鎖名	残基
A	GLN115
A	ASP116
A	ARG154
A	GLY196
A	GLY197
A	ARG404
A	THR450
A	THR451
A	ARG454
A	LYS474
A	SF4601
A	HOH826

site_id	AC9
残基数	3
詳細	binding site for residue 1PE A 609

鎖名	残基
A	GLN354
B	GLN354
B	TYR355

site_id	AD1
残基数	7
詳細	binding site for residue 1PE A 610

鎖名	残基
A	ALA409
A	ARG412
A	GLU413
A	GLU416
A	HOH827
B	ASN213
B	SER216

site_id	AD2
残基数	4
詳細	binding site for residue 1PE A 611

鎖名	残基
A	GLN463
A	GLY466
A	TYR488
A	HOH892

site_id	AD3
残基数	8
詳細	binding site for residue SF4 B 601

鎖名	残基
B	CYS114
B	GLN115
B	GLY195
B	CYS233
B	CYS328
B	ALA330
B	LYS474
B	JYD604

site_id	AD4
残基数	3
詳細	binding site for residue GOL B 602

鎖名	残基
B	HIS23
B	TYR28
B	LYS337

site_id	AD5
残基数	3
詳細	binding site for residue GOL B 603

鎖名	残基
B	GLY520
B	MET521
B	HOH816

site_id	AD6
残基数	12
詳細	binding site for residue JYD B 604

鎖名	残基
B	GLN115
B	ASP116
B	ARG154
B	GLY196
B	GLY197
B	ARG404
B	THR450
B	THR451
B	ARG454
B	LYS474
B	SF4601
B	HOH717

site_id	AD7
残基数	2
詳細	binding site for residue 1PE B 605

鎖名	残基
B	LYS33
B	ASP341

site_id	AD8
残基数	6
詳細	binding site for residue 1PE B 606

鎖名	残基
B	GLU87
B	GLN291
B	LYS302
B	HOH774
B	HOH793
B	HOH794

site_id	AD9
残基数	9
詳細	binding site for residue SF4 C 601

鎖名	残基
C	CYS114
C	GLN115
C	GLY195
C	ALA232
C	CYS233
C	CYS328
C	ALA330
C	LYS474
C	JYD604

site_id	AE1
残基数	5
詳細	binding site for residue GOL C 602

鎖名	残基
D	HOH775
C	LYS215
C	SER216
C	ASN219
C	HOH802

site_id	AE2
残基数	2
詳細	binding site for residue 1PE C 603

鎖名	残基
C	GLN354
D	ARG80

site_id	AE3
残基数	12
詳細	binding site for residue JYD C 604

鎖名	残基
C	GLN115
C	ASP116
C	ARG154
C	GLY196
C	GLY197
C	ARG404
C	THR450
C	THR451
C	ARG454
C	LYS474
C	SF4601
C	HOH718

site_id	AE4
残基数	6
詳細	binding site for residue 1PE C 605

鎖名	残基
C	GLU87
C	GLU284
C	LYS288
C	GLN291
C	LYS302
C	HOH764

site_id	AE5
残基数	7
詳細	binding site for residue 1PE C 606

鎖名	残基
C	SER78
C	LYS81
C	TYR303
C	HIS306
C	ASP307
C	ARG309
C	HOH764

site_id	AE6
残基数	8
詳細	binding site for residue SF4 D 601

鎖名	残基
D	CYS114
D	GLN115
D	ALA232
D	CYS233
D	CYS328
D	ALA330
D	LYS474
D	JYD602

site_id	AE7
残基数	10
詳細	binding site for residue JYD D 602

鎖名	残基
D	GLN115
D	ASP116
D	ARG154
D	GLY197
D	ARG404
D	THR450
D	THR451
D	ARG454
D	LYS474
D	SF4601

site_id	AE8
残基数	4
詳細	binding site for residue 1PE D 603

鎖名	残基
B	LYS487
B	TYR488
D	LYS33
D	ASP341

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00163
残基数	10
詳細	FUMARATE_LYASES Fumarate lyases signature. GSmvMlAKgN

鎖名	残基	詳細
A	GLY467-ASN476

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	12
詳細	BINDING: BINDING => ECO:0000269\|PubMed:30645090, ECO:0007744\|PDB:6MSO

鎖名	残基	詳細
A	CYS114
D	CYS114
D	CYS233
D	CYS328
A	CYS233
A	CYS328
B	CYS114
B	CYS233
B	CYS328
C	CYS114
C	CYS233
C	CYS328

site_id	SWS_FT_FI2
残基数	28
詳細	BINDING: BINDING => ECO:0000250\|UniProtKB:E9AE57

鎖名	残基	詳細
A	GLN115
B	GLY197
B	ASN200
B	ARG404
B	THR450
B	LYS474
C	GLN115
C	ARG154
C	GLY197
C	ASN200
C	ARG404
A	ARG154
C	THR450
C	LYS474
D	GLN115
D	ARG154
D	GLY197
D	ASN200
D	ARG404
D	THR450
D	LYS474
A	GLY197
A	ASN200
A	ARG404
A	THR450
A	LYS474
B	GLN115
B	ARG154

		Sequence (fasta)
		PDBx/mmCIF
		PDBML (ヘッダのみ (no-atom))
		PDB形式 (全ての情報)
		検証レポート (PDF)
		EDMap 2fo-fc (MTZ)