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6MSD

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000502cellular_componentproteasome complex
A0000932cellular_componentP-body
A0001649biological_processosteoblast differentiation
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0008540cellular_componentproteasome regulatory particle, base subcomplex
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0022624cellular_componentproteasome accessory complex
A0034774cellular_componentsecretory granule lumen
A0036402molecular_functionproteasome-activating activity
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A1901800biological_processpositive regulation of proteasomal protein catabolic process
A1904813cellular_componentficolin-1-rich granule lumen
B0000166molecular_functionnucleotide binding
B0000502cellular_componentproteasome complex
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005838cellular_componentproteasome regulatory particle
B0008540cellular_componentproteasome regulatory particle, base subcomplex
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0022624cellular_componentproteasome accessory complex
B0036402molecular_functionproteasome-activating activity
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B1901800biological_processpositive regulation of proteasomal protein catabolic process
C0000166molecular_functionnucleotide binding
C0000502cellular_componentproteasome complex
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005838cellular_componentproteasome regulatory particle
C0006357biological_processregulation of transcription by RNA polymerase II
C0008134molecular_functiontranscription factor binding
C0008540cellular_componentproteasome regulatory particle, base subcomplex
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0022624cellular_componentproteasome accessory complex
C0031410cellular_componentcytoplasmic vesicle
C0031531molecular_functionthyrotropin-releasing hormone receptor binding
C0036402molecular_functionproteasome-activating activity
C0043069biological_processnegative regulation of programmed cell death
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0070062cellular_componentextracellular exosome
C0072562cellular_componentblood microparticle
C0140296molecular_functiongeneral transcription initiation factor binding
C0140297molecular_functionDNA-binding transcription factor binding
C1901800biological_processpositive regulation of proteasomal protein catabolic process
D0000166molecular_functionnucleotide binding
D0000502cellular_componentproteasome complex
D0001824biological_processblastocyst development
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0008540cellular_componentproteasome regulatory particle, base subcomplex
D0016020cellular_componentmembrane
D0016234cellular_componentinclusion body
D0016887molecular_functionATP hydrolysis activity
D0022624cellular_componentproteasome accessory complex
D0031597cellular_componentcytosolic proteasome complex
D0036402molecular_functionproteasome-activating activity
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045202cellular_componentsynapse
D1901800biological_processpositive regulation of proteasomal protein catabolic process
E0000166molecular_functionnucleotide binding
E0000502cellular_componentproteasome complex
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0008540cellular_componentproteasome regulatory particle, base subcomplex
E0016020cellular_componentmembrane
E0016234cellular_componentinclusion body
E0016887molecular_functionATP hydrolysis activity
E0022624cellular_componentproteasome accessory complex
E0030674molecular_functionprotein-macromolecule adaptor activity
E0031597cellular_componentcytosolic proteasome complex
E0036402molecular_functionproteasome-activating activity
E0036503biological_processERAD pathway
E0042802molecular_functionidentical protein binding
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
E0070062cellular_componentextracellular exosome
E0090261biological_processpositive regulation of inclusion body assembly
E1901800biological_processpositive regulation of proteasomal protein catabolic process
F0000166molecular_functionnucleotide binding
F0000502cellular_componentproteasome complex
F0000932cellular_componentP-body
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0008540cellular_componentproteasome regulatory particle, base subcomplex
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0022624cellular_componentproteasome accessory complex
F0034774cellular_componentsecretory granule lumen
F0036402molecular_functionproteasome-activating activity
F0042802molecular_functionidentical protein binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043921biological_processmodulation by host of viral transcription
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F1901800biological_processpositive regulation of proteasomal protein catabolic process
F1904813cellular_componentficolin-1-rich granule lumen
G0000502cellular_componentproteasome complex
G0000932cellular_componentP-body
G0003723molecular_functionRNA binding
G0004175molecular_functionendopeptidase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005839cellular_componentproteasome core complex
G0005840cellular_componentribosome
G0006511biological_processubiquitin-dependent protein catabolic process
G0010498biological_processproteasomal protein catabolic process
G0016363cellular_componentnuclear matrix
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0030016cellular_componentmyofibril
G0030017cellular_componentsarcomere
G0035639molecular_functionpurine ribonucleoside triphosphate binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0050727biological_processregulation of inflammatory response
G0051059molecular_functionNF-kappaB binding
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0051603biological_processproteolysis involved in protein catabolic process
G0070062cellular_componentextracellular exosome
H0000502cellular_componentproteasome complex
H0000932cellular_componentP-body
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005839cellular_componentproteasome core complex
H0006511biological_processubiquitin-dependent protein catabolic process
H0009615biological_processresponse to virus
H0010498biological_processproteasomal protein catabolic process
H0019773cellular_componentproteasome core complex, alpha-subunit complex
H0034774cellular_componentsecretory granule lumen
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
H0070062cellular_componentextracellular exosome
H1904813cellular_componentficolin-1-rich granule lumen
I0000502cellular_componentproteasome complex
I0000932cellular_componentP-body
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005839cellular_componentproteasome core complex
I0006511biological_processubiquitin-dependent protein catabolic process
I0010498biological_processproteasomal protein catabolic process
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043231cellular_componentintracellular membrane-bounded organelle
I0051603biological_processproteolysis involved in protein catabolic process
I0070062cellular_componentextracellular exosome
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0006511biological_processubiquitin-dependent protein catabolic process
J0010498biological_processproteasomal protein catabolic process
J0019773cellular_componentproteasome core complex, alpha-subunit complex
J0042802molecular_functionidentical protein binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0070062cellular_componentextracellular exosome
J0098794cellular_componentpostsynapse
K0000502cellular_componentproteasome complex
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005839cellular_componentproteasome core complex
K0006511biological_processubiquitin-dependent protein catabolic process
K0010498biological_processproteasomal protein catabolic process
K0019773cellular_componentproteasome core complex, alpha-subunit complex
K0034774cellular_componentsecretory granule lumen
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
K0070062cellular_componentextracellular exosome
K1904813cellular_componentficolin-1-rich granule lumen
L0000502cellular_componentproteasome complex
L0001530molecular_functionlipopolysaccharide binding
L0002376biological_processimmune system process
L0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005829cellular_componentcytosol
L0005839cellular_componentproteasome core complex
L0006511biological_processubiquitin-dependent protein catabolic process
L0010498biological_processproteasomal protein catabolic process
L0019773cellular_componentproteasome core complex, alpha-subunit complex
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
L0070062cellular_componentextracellular exosome
M0000502cellular_componentproteasome complex
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005839cellular_componentproteasome core complex
M0006511biological_processubiquitin-dependent protein catabolic process
M0010498biological_processproteasomal protein catabolic process
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0031625molecular_functionubiquitin protein ligase binding
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0045202cellular_componentsynapse
M0051603biological_processproteolysis involved in protein catabolic process
M0052548biological_processregulation of endopeptidase activity
M0070062cellular_componentextracellular exosome
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005839cellular_componentproteasome core complex
N0006508biological_processproteolysis
N0008233molecular_functionpeptidase activity
N0016787molecular_functionhydrolase activity
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0045296molecular_functioncadherin binding
N0051603biological_processproteolysis involved in protein catabolic process
N0070062cellular_componentextracellular exosome
O0000502cellular_componentproteasome complex
O0004175molecular_functionendopeptidase activity
O0004298molecular_functionthreonine-type endopeptidase activity
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005839cellular_componentproteasome core complex
O0006508biological_processproteolysis
O0008233molecular_functionpeptidase activity
O0016604cellular_componentnuclear body
O0016787molecular_functionhydrolase activity
O0019774cellular_componentproteasome core complex, beta-subunit complex
O0034774cellular_componentsecretory granule lumen
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
O1904813cellular_componentficolin-1-rich granule lumen
P0000502cellular_componentproteasome complex
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005839cellular_componentproteasome core complex
P0019774cellular_componentproteasome core complex, beta-subunit complex
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0051603biological_processproteolysis involved in protein catabolic process
P0070062cellular_componentextracellular exosome
Q0000502cellular_componentproteasome complex
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005839cellular_componentproteasome core complex
Q0010243biological_processresponse to organonitrogen compound
Q0010498biological_processproteasomal protein catabolic process
Q0014070biological_processresponse to organic cyclic compound
Q0016020cellular_componentmembrane
Q0019774cellular_componentproteasome core complex, beta-subunit complex
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
Q0070062cellular_componentextracellular exosome
R0000502cellular_componentproteasome complex
R0004175molecular_functionendopeptidase activity
R0004298molecular_functionthreonine-type endopeptidase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005813cellular_componentcentrosome
R0005829cellular_componentcytosol
R0005839cellular_componentproteasome core complex
R0006508biological_processproteolysis
R0006979biological_processresponse to oxidative stress
R0008233molecular_functionpeptidase activity
R0016787molecular_functionhydrolase activity
R0019774cellular_componentproteasome core complex, beta-subunit complex
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
R0070062cellular_componentextracellular exosome
S0000502cellular_componentproteasome complex
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0005839cellular_componentproteasome core complex
S0019774cellular_componentproteasome core complex, beta-subunit complex
S0034774cellular_componentsecretory granule lumen
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
S0070062cellular_componentextracellular exosome
S1904813cellular_componentficolin-1-rich granule lumen
T0000502cellular_componentproteasome complex
T0001530molecular_functionlipopolysaccharide binding
T0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005737cellular_componentcytoplasm
T0005739cellular_componentmitochondrion
T0005829cellular_componentcytosol
T0005839cellular_componentproteasome core complex
T0019774cellular_componentproteasome core complex, beta-subunit complex
T0036064cellular_componentciliary basal body
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0051603biological_processproteolysis involved in protein catabolic process
T0070062cellular_componentextracellular exosome
U0000502cellular_componentproteasome complex
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005829cellular_componentcytosol
U0005838cellular_componentproteasome regulatory particle
U0008540cellular_componentproteasome regulatory particle, base subcomplex
U0016020cellular_componentmembrane
U0022624cellular_componentproteasome accessory complex
U0030234molecular_functionenzyme regulator activity
U0031625molecular_functionubiquitin protein ligase binding
U0034515cellular_componentproteasome storage granule
U0035578cellular_componentazurophil granule lumen
U0042176biological_processregulation of protein catabolic process
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0000502cellular_componentproteasome complex
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005829cellular_componentcytosol
V0005838cellular_componentproteasome regulatory particle
V0006511biological_processubiquitin-dependent protein catabolic process
V0008541cellular_componentproteasome regulatory particle, lid subcomplex
V0016020cellular_componentmembrane
V0022624cellular_componentproteasome accessory complex
V0030234molecular_functionenzyme regulator activity
V0032991cellular_componentprotein-containing complex
V0034774cellular_componentsecretory granule lumen
V0042176biological_processregulation of protein catabolic process
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0070062cellular_componentextracellular exosome
V1904813cellular_componentficolin-1-rich granule lumen
W0000502cellular_componentproteasome complex
W0005515molecular_functionprotein binding
W0005576cellular_componentextracellular region
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0005838cellular_componentproteasome regulatory particle
W0008541cellular_componentproteasome regulatory particle, lid subcomplex
W0016020cellular_componentmembrane
W0022624cellular_componentproteasome accessory complex
W0034774cellular_componentsecretory granule lumen
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0070062cellular_componentextracellular exosome
W1904813cellular_componentficolin-1-rich granule lumen
X0000502cellular_componentproteasome complex
X0005198molecular_functionstructural molecule activity
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005838cellular_componentproteasome regulatory particle
X0006511biological_processubiquitin-dependent protein catabolic process
X0008541cellular_componentproteasome regulatory particle, lid subcomplex
X0016020cellular_componentmembrane
X0022624cellular_componentproteasome accessory complex
X0032991cellular_componentprotein-containing complex
X0034774cellular_componentsecretory granule lumen
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0043248biological_processproteasome assembly
X0048863biological_processstem cell differentiation
X1904813cellular_componentficolin-1-rich granule lumen
Y0000502cellular_componentproteasome complex
Y0005515molecular_functionprotein binding
Y0005576cellular_componentextracellular region
Y0005654cellular_componentnucleoplasm
Y0005829cellular_componentcytosol
Y0005838cellular_componentproteasome regulatory particle
Y0022624cellular_componentproteasome accessory complex
Y0034774cellular_componentsecretory granule lumen
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y1904813cellular_componentficolin-1-rich granule lumen
Z0000502cellular_componentproteasome complex
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005829cellular_componentcytosol
Z0005838cellular_componentproteasome regulatory particle
Z0008233molecular_functionpeptidase activity
Z0008237molecular_functionmetallopeptidase activity
Z0016020cellular_componentmembrane
Z0034774cellular_componentsecretory granule lumen
Z0042803molecular_functionprotein homodimerization activity
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0070062cellular_componentextracellular exosome
Z0140492molecular_functionmetal-dependent deubiquitinase activity
Z1904813cellular_componentficolin-1-rich granule lumen
a0000502cellular_componentproteasome complex
a0005198molecular_functionstructural molecule activity
a0005576cellular_componentextracellular region
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005829cellular_componentcytosol
a0005838cellular_componentproteasome regulatory particle
a0006511biological_processubiquitin-dependent protein catabolic process
a0007127biological_processmeiosis I
a0008541cellular_componentproteasome regulatory particle, lid subcomplex
a0016020cellular_componentmembrane
a0022624cellular_componentproteasome accessory complex
a0034774cellular_componentsecretory granule lumen
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a1904813cellular_componentficolin-1-rich granule lumen
b0000502cellular_componentproteasome complex
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005829cellular_componentcytosol
b0008540cellular_componentproteasome regulatory particle, base subcomplex
b0022624cellular_componentproteasome accessory complex
b0031593molecular_functionpolyubiquitin modification-dependent protein binding
b0042802molecular_functionidentical protein binding
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0060090molecular_functionmolecular adaptor activity
c0000502cellular_componentproteasome complex
c0000724biological_processdouble-strand break repair via homologous recombination
c0005515molecular_functionprotein binding
c0005576cellular_componentextracellular region
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005829cellular_componentcytosol
c0006281biological_processDNA repair
c0006303biological_processdouble-strand break repair via nonhomologous end joining
c0006508biological_processproteolysis
c0006511biological_processubiquitin-dependent protein catabolic process
c0006974biological_processDNA damage response
c0008233molecular_functionpeptidase activity
c0008237molecular_functionmetallopeptidase activity
c0008541cellular_componentproteasome regulatory particle, lid subcomplex
c0016787molecular_functionhydrolase activity
c0022624cellular_componentproteasome accessory complex
c0031597cellular_componentcytosolic proteasome complex
c0034774cellular_componentsecretory granule lumen
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0045471biological_processresponse to ethanol
c0046872molecular_functionmetal ion binding
c0061133molecular_functionendopeptidase activator activity
c0061136biological_processregulation of proteasomal protein catabolic process
c0061578molecular_functionK63-linked deubiquitinase activity
c0070536biological_processprotein K63-linked deubiquitination
c0070628molecular_functionproteasome binding
c0140492molecular_functionmetal-dependent deubiquitinase activity
c1904813cellular_componentficolin-1-rich granule lumen
d0000502cellular_componentproteasome complex
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005829cellular_componentcytosol
d0005838cellular_componentproteasome regulatory particle
d0006508biological_processproteolysis
d0008541cellular_componentproteasome regulatory particle, lid subcomplex
d0022624cellular_componentproteasome accessory complex
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
e0000502cellular_componentproteasome complex
e0000724biological_processdouble-strand break repair via homologous recombination
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005829cellular_componentcytosol
e0006406biological_processmRNA export from nucleus
e0008541cellular_componentproteasome regulatory particle, lid subcomplex
e0032039cellular_componentintegrator complex
e0032991cellular_componentprotein-containing complex
e0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
e0043248biological_processproteasome assembly
f0000502cellular_componentproteasome complex
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005829cellular_componentcytosol
f0005838cellular_componentproteasome regulatory particle
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0016020cellular_componentmembrane
f0022624cellular_componentproteasome accessory complex
f0030234molecular_functionenzyme regulator activity
f0034515cellular_componentproteasome storage granule
f0034774cellular_componentsecretory granule lumen
f0042176biological_processregulation of protein catabolic process
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0070062cellular_componentextracellular exosome
f1904813cellular_componentficolin-1-rich granule lumen
g0000502cellular_componentproteasome complex
g0000932cellular_componentP-body
g0003723molecular_functionRNA binding
g0004175molecular_functionendopeptidase activity
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0005839cellular_componentproteasome core complex
g0005840cellular_componentribosome
g0006511biological_processubiquitin-dependent protein catabolic process
g0010498biological_processproteasomal protein catabolic process
g0016363cellular_componentnuclear matrix
g0019773cellular_componentproteasome core complex, alpha-subunit complex
g0030016cellular_componentmyofibril
g0030017cellular_componentsarcomere
g0035639molecular_functionpurine ribonucleoside triphosphate binding
g0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
g0050727biological_processregulation of inflammatory response
g0051059molecular_functionNF-kappaB binding
g0051092biological_processpositive regulation of NF-kappaB transcription factor activity
g0051603biological_processproteolysis involved in protein catabolic process
g0070062cellular_componentextracellular exosome
h0000502cellular_componentproteasome complex
h0000932cellular_componentP-body
h0005515molecular_functionprotein binding
h0005576cellular_componentextracellular region
h0005634cellular_componentnucleus
h0005654cellular_componentnucleoplasm
h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
h0005839cellular_componentproteasome core complex
h0006511biological_processubiquitin-dependent protein catabolic process
h0009615biological_processresponse to virus
h0010498biological_processproteasomal protein catabolic process
h0019773cellular_componentproteasome core complex, alpha-subunit complex
h0034774cellular_componentsecretory granule lumen
h0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
h0051603biological_processproteolysis involved in protein catabolic process
h0070062cellular_componentextracellular exosome
h1904813cellular_componentficolin-1-rich granule lumen
i0000502cellular_componentproteasome complex
i0000932cellular_componentP-body
i0005515molecular_functionprotein binding
i0005634cellular_componentnucleus
i0005654cellular_componentnucleoplasm
i0005737cellular_componentcytoplasm
i0005829cellular_componentcytosol
i0005839cellular_componentproteasome core complex
i0006511biological_processubiquitin-dependent protein catabolic process
i0010498biological_processproteasomal protein catabolic process
i0019773cellular_componentproteasome core complex, alpha-subunit complex
i0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
i0043231cellular_componentintracellular membrane-bounded organelle
i0051603biological_processproteolysis involved in protein catabolic process
i0070062cellular_componentextracellular exosome
j0000502cellular_componentproteasome complex
j0005515molecular_functionprotein binding
j0005634cellular_componentnucleus
j0005654cellular_componentnucleoplasm
j0005737cellular_componentcytoplasm
j0005829cellular_componentcytosol
j0005839cellular_componentproteasome core complex
j0006511biological_processubiquitin-dependent protein catabolic process
j0010498biological_processproteasomal protein catabolic process
j0019773cellular_componentproteasome core complex, alpha-subunit complex
j0042802molecular_functionidentical protein binding
j0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
j0051603biological_processproteolysis involved in protein catabolic process
j0070062cellular_componentextracellular exosome
j0098794cellular_componentpostsynapse
k0000502cellular_componentproteasome complex
k0005515molecular_functionprotein binding
k0005576cellular_componentextracellular region
k0005634cellular_componentnucleus
k0005654cellular_componentnucleoplasm
k0005737cellular_componentcytoplasm
k0005829cellular_componentcytosol
k0005839cellular_componentproteasome core complex
k0006511biological_processubiquitin-dependent protein catabolic process
k0010498biological_processproteasomal protein catabolic process
k0019773cellular_componentproteasome core complex, alpha-subunit complex
k0034774cellular_componentsecretory granule lumen
k0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
k0051603biological_processproteolysis involved in protein catabolic process
k0070062cellular_componentextracellular exosome
k1904813cellular_componentficolin-1-rich granule lumen
l0000502cellular_componentproteasome complex
l0001530molecular_functionlipopolysaccharide binding
l0002376biological_processimmune system process
l0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
l0005515molecular_functionprotein binding
l0005634cellular_componentnucleus
l0005654cellular_componentnucleoplasm
l0005737cellular_componentcytoplasm
l0005813cellular_componentcentrosome
l0005829cellular_componentcytosol
l0005839cellular_componentproteasome core complex
l0006511biological_processubiquitin-dependent protein catabolic process
l0010498biological_processproteasomal protein catabolic process
l0019773cellular_componentproteasome core complex, alpha-subunit complex
l0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
l0051603biological_processproteolysis involved in protein catabolic process
l0070062cellular_componentextracellular exosome
m0000502cellular_componentproteasome complex
m0005515molecular_functionprotein binding
m0005634cellular_componentnucleus
m0005654cellular_componentnucleoplasm
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0005839cellular_componentproteasome core complex
m0006511biological_processubiquitin-dependent protein catabolic process
m0010498biological_processproteasomal protein catabolic process
m0019773cellular_componentproteasome core complex, alpha-subunit complex
m0031625molecular_functionubiquitin protein ligase binding
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m0045202cellular_componentsynapse
m0051603biological_processproteolysis involved in protein catabolic process
m0052548biological_processregulation of endopeptidase activity
m0070062cellular_componentextracellular exosome
n0000502cellular_componentproteasome complex
n0004175molecular_functionendopeptidase activity
n0004298molecular_functionthreonine-type endopeptidase activity
n0005515molecular_functionprotein binding
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005737cellular_componentcytoplasm
n0005739cellular_componentmitochondrion
n0005829cellular_componentcytosol
n0005839cellular_componentproteasome core complex
n0006508biological_processproteolysis
n0008233molecular_functionpeptidase activity
n0016787molecular_functionhydrolase activity
n0019774cellular_componentproteasome core complex, beta-subunit complex
n0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
n0045296molecular_functioncadherin binding
n0051603biological_processproteolysis involved in protein catabolic process
n0070062cellular_componentextracellular exosome
o0000502cellular_componentproteasome complex
o0004175molecular_functionendopeptidase activity
o0004298molecular_functionthreonine-type endopeptidase activity
o0005515molecular_functionprotein binding
o0005576cellular_componentextracellular region
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0005737cellular_componentcytoplasm
o0005829cellular_componentcytosol
o0005839cellular_componentproteasome core complex
o0006508biological_processproteolysis
o0008233molecular_functionpeptidase activity
o0016604cellular_componentnuclear body
o0016787molecular_functionhydrolase activity
o0019774cellular_componentproteasome core complex, beta-subunit complex
o0034774cellular_componentsecretory granule lumen
o0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
o0051603biological_processproteolysis involved in protein catabolic process
o1904813cellular_componentficolin-1-rich granule lumen
p0000502cellular_componentproteasome complex
p0005515molecular_functionprotein binding
p0005634cellular_componentnucleus
p0005654cellular_componentnucleoplasm
p0005737cellular_componentcytoplasm
p0005829cellular_componentcytosol
p0005839cellular_componentproteasome core complex
p0019774cellular_componentproteasome core complex, beta-subunit complex
p0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
p0051603biological_processproteolysis involved in protein catabolic process
p0070062cellular_componentextracellular exosome
q0000502cellular_componentproteasome complex
q0005515molecular_functionprotein binding
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005737cellular_componentcytoplasm
q0005829cellular_componentcytosol
q0005839cellular_componentproteasome core complex
q0010243biological_processresponse to organonitrogen compound
q0010498biological_processproteasomal protein catabolic process
q0014070biological_processresponse to organic cyclic compound
q0016020cellular_componentmembrane
q0019774cellular_componentproteasome core complex, beta-subunit complex
q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
q0051603biological_processproteolysis involved in protein catabolic process
q0070062cellular_componentextracellular exosome
r0000502cellular_componentproteasome complex
r0004175molecular_functionendopeptidase activity
r0004298molecular_functionthreonine-type endopeptidase activity
r0005515molecular_functionprotein binding
r0005634cellular_componentnucleus
r0005654cellular_componentnucleoplasm
r0005737cellular_componentcytoplasm
r0005813cellular_componentcentrosome
r0005829cellular_componentcytosol
r0005839cellular_componentproteasome core complex
r0006508biological_processproteolysis
r0006979biological_processresponse to oxidative stress
r0008233molecular_functionpeptidase activity
r0016787molecular_functionhydrolase activity
r0019774cellular_componentproteasome core complex, beta-subunit complex
r0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
r0051603biological_processproteolysis involved in protein catabolic process
r0070062cellular_componentextracellular exosome
s0000502cellular_componentproteasome complex
s0005515molecular_functionprotein binding
s0005576cellular_componentextracellular region
s0005634cellular_componentnucleus
s0005654cellular_componentnucleoplasm
s0005737cellular_componentcytoplasm
s0005829cellular_componentcytosol
s0005839cellular_componentproteasome core complex
s0019774cellular_componentproteasome core complex, beta-subunit complex
s0034774cellular_componentsecretory granule lumen
s0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
s0051603biological_processproteolysis involved in protein catabolic process
s0070062cellular_componentextracellular exosome
s1904813cellular_componentficolin-1-rich granule lumen
t0000502cellular_componentproteasome complex
t0001530molecular_functionlipopolysaccharide binding
t0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
t0005515molecular_functionprotein binding
t0005634cellular_componentnucleus
t0005654cellular_componentnucleoplasm
t0005737cellular_componentcytoplasm
t0005739cellular_componentmitochondrion
t0005829cellular_componentcytosol
t0005839cellular_componentproteasome core complex
t0019774cellular_componentproteasome core complex, beta-subunit complex
t0036064cellular_componentciliary basal body
t0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
t0051603biological_processproteolysis involved in protein catabolic process
t0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN c 401
ChainResidue
cGLU52
cHIS113
cHIS115
cASP126

site_idAC2
Number of Residues17
Detailsbinding site for residue ATP A 501
ChainResidue
AGLY221
ALYS222
ATHR223
ALEU224
AILE354
AHIS358
AGLY382
AALA383
AMG502
BASP317
BARG343
BARG346
AASP176
AGLY178
APRO218
AGLY219
ATHR220

site_idAC3
Number of Residues2
Detailsbinding site for residue MG A 502
ChainResidue
ATHR223
AATP501

site_idAC4
Number of Residues14
Detailsbinding site for residue ATP B 501
ChainResidue
BILE187
BPRO228
BGLY229
BTHR230
BGLY231
BLYS232
BTHR233
BLEU234
BHIS368
BGLY392
BALA393
BLYS396
BMG502
CARG307

site_idAC5
Number of Residues2
Detailsbinding site for residue MG B 502
ChainResidue
BTHR233
BATP501

site_idAC6
Number of Residues12
Detailsbinding site for residue ADP C 501
ChainResidue
CMET150
CGLY152
CPRO192
CGLY193
CTHR194
CGLY195
CLYS196
CTHR197
CLEU198
CILE328
CGLY356
CLYS360

site_idAC7
Number of Residues15
Detailsbinding site for residue ATP D 501
ChainResidue
DILE167
DGLY168
DPRO208
DGLY209
DCYS210
DGLY211
DLYS212
DTHR213
DMET214
DGLY372
DALA373
DASN376
DMG502
EARG291
EARG294

site_idAC8
Number of Residues2
Detailsbinding site for residue MG D 502
ChainResidue
DTHR213
DATP501

site_idAC9
Number of Residues18
Detailsbinding site for residue ATP E 401
ChainResidue
EILE135
EGLY136
EPRO176
EGLY177
ETHR178
EGLY179
ELYS180
ETHR181
ELEU182
EGLU234
EASN280
EILE312
EHIS316
EGLY340
EALA341
EMG402
FARG344
FARG347

site_idAD1
Number of Residues2
Detailsbinding site for residue MG E 402
ChainResidue
ETHR181
EATP401

site_idAD2
Number of Residues13
Detailsbinding site for residue ADP F 501
ChainResidue
FLYS397
FMG502
FGLY189
FPRO229
FGLY230
FTHR231
FGLY232
FLYS233
FTHR234
FLEU235
FILE365
FHIS369
FGLY393

site_idAD3
Number of Residues4
Detailsbinding site for residue MG F 502
ChainResidue
FTHR234
FASP286
FGLU287
FADP501

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
uLYS27-ASP52

site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV
ChainResidueDetails
dALA-21-VAL-6

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IkVLmATNrpdtLDpALm.R
ChainResidueDetails
AILE315-ARG333
DVAL305-ARG323
BVAL325-ARG343
CILE289-ARG307
FVAL326-ARG344
EVAL273-ARG291

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAMkGknCVAIAADrrfgiqaqmvttdfq.KifpmgdrlyiglaGlaTD
ChainResidueDetails
PMET12-ASP59
iLEU35-ASP82
NMET4-ASP51
SLEU13-ASP60
OALA4-ASP51
TLEU12-ASP59
QILE5-ASP52
RLEU4-ASP51

site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA
ChainResidueDetails
MTYR7-ALA29
jTYR3-ALA25
iTYR5-ALA27
hTYR6-ALA28
lTYR6-ALA28
kTYR8-ALA30
gPHE9-ALA31

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
EGLY174
tSER-19
SSER134
sSER34
sSER40
sSER134

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS72
ELYS206
MLYS229
mLYS56
mLYS205
mLYS229

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER244
sLYS176
iLYS127
iLYS176
hSER14
hSER16

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
SSER30
SSER181
sSER30
sSER181
lLYS208

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
KSER198
kSER198
hLYS70
hLYS171

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HTYR76
hTYR76

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220
ChainResidueDetails
HTYR121
hTYR121
wGLY76

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
ChainResidueDetails
uLYS11
uLYS48
wLYS11
wLYS48

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
ChainResidueDetails
uLYS27
wLYS27

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
ChainResidueDetails
uLYS29
wLYS29

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
ChainResidueDetails
uLYS33
wLYS33

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
ChainResidueDetails
uARG63
wARG63

217705

數據於2024-03-27公開中

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