6IX3
The structure of LepI complex with SAM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018130 | biological_process | obsolete heterocycle biosynthetic process |
| A | 0032259 | biological_process | methylation |
| A | 0044550 | biological_process | secondary metabolite biosynthetic process |
| A | 1901362 | biological_process | organic cyclic compound biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018130 | biological_process | obsolete heterocycle biosynthetic process |
| B | 0032259 | biological_process | methylation |
| B | 0044550 | biological_process | secondary metabolite biosynthetic process |
| B | 1901362 | biological_process | organic cyclic compound biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue SAM A 401 |
| Chain | Residue |
| A | LEU193 |
| A | HIS277 |
| A | ARG291 |
| A | LEU292 |
| A | HOH516 |
| A | HOH556 |
| A | HOH609 |
| A | HOH645 |
| A | GLY227 |
| A | GLY229 |
| A | ASP252 |
| A | LEU253 |
| A | VAL256 |
| A | HIS274 |
| A | ASN275 |
| A | PHE276 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | TYR241 |
| A | PRO242 |
| A | ASN243 |
| A | GLN244 |
| B | PRO279 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue SAM B 401 |
| Chain | Residue |
| B | PHE189 |
| B | LEU193 |
| B | GLY227 |
| B | GLY229 |
| B | ASP252 |
| B | VAL256 |
| B | HIS274 |
| B | ASN275 |
| B | PHE276 |
| B | HIS277 |
| B | ARG291 |
| B | LEU292 |
| B | HOH559 |
| B | HOH567 |
| B | HOH570 |
| B | HOH631 |
| B | HOH648 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE135 | |
| B | PHE135 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O04385 |
| Chain | Residue | Details |
| A | GLY227 | |
| A | ASN275 | |
| A | ARG291 | |
| B | GLY227 | |
| B | ASN275 | |
| B | ARG291 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01020 |
| Chain | Residue | Details |
| A | ASP252 | |
| B | ASP252 |
