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6I2D

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp117

6EMD」から置き換えられました
GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0010737biological_processprotein kinase A signaling
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030145molecular_functionmanganese ion binding
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034605biological_processcellular response to heat
A0036126cellular_componentsperm flagellum
A0043197cellular_componentdendritic spine
A0044853cellular_componentplasma membrane raft
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0051726biological_processregulation of cell cycle
A0061136biological_processregulation of proteasomal protein catabolic process
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0097546cellular_componentciliary base
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
D0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
D0006469biological_processnegative regulation of protein kinase activity
PDBデータベースに由来する情報
site_idAC1
残基数11
詳細binding site for residue 9LQ A 401
鎖名残基
ATHR51
AASP184
AHOH505
AGLY52
AVAL57
AALA70
ALYS72
AGLU121
ATYR122
AVAL123
ALEU173

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00107
残基数24
詳細PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK
鎖名残基詳細
ALEU49-LYS72

site_idPS00108
残基数13
詳細PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
鎖名残基詳細
ALEU162-ILE174

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数1
詳細ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
鎖名残基詳細
AASP166

site_idSWS_FT_FI2
残基数4
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
鎖名残基詳細
ALYS72
AGLU121
ALYS168
ALEU49

site_idSWS_FT_FI3
残基数1
詳細MOD_RES: Deamidated asparagine => ECO:0000250|UniProtKB:P05132
鎖名残基詳細
AASN2

site_idSWS_FT_FI4
残基数1
詳細MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132
鎖名残基詳細
ASEP10

site_idSWS_FT_FI5
残基数2
詳細MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612
鎖名残基詳細
ATHR195
ATHR48

site_idSWS_FT_FI6
残基数1
詳細MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132
鎖名残基詳細
ASEP139

site_idSWS_FT_FI7
残基数1
詳細MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000250|UniProtKB:P00517
鎖名残基詳細
ATPO197

site_idSWS_FT_FI8
残基数1
詳細MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132
鎖名残基詳細
ATYR330

site_idSWS_FT_FI9
残基数1
詳細MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00517
鎖名残基詳細
ASEP338

site_idSWS_FT_FI10
残基数1
詳細LIPID: N-myristoyl glycine => ECO:0000250|UniProtKB:P17612
鎖名残基詳細
AGLY1

218500

件を2024-04-17に公開中

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