6H23

Crystal structure of the hClpP Y118A mutant with an activating small molecule

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0006508	biological_process	proteolysis
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0006508	biological_process	proteolysis
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0006508	biological_process	proteolysis
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0006508	biological_process	proteolysis
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0006508	biological_process	proteolysis
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0006508	biological_process	proteolysis
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0006508	biological_process	proteolysis

PDBデータベースに由来する情報

site_id	AC1
残基数	10
詳細	binding site for residue FJT A 301

鎖名	残基
A	ALA101
B	VAL148
A	LEU104
A	PHE105
A	SER108
A	TYR138
B	LEU79
B	GLU82
B	ILE84
B	TRP146

site_id	AC2
残基数	4
詳細	binding site for residue EDO A 302

鎖名	残基
A	GLN194
A	ALA195
H	GLN179
H	LYS202

site_id	AC3
残基数	14
詳細	binding site for residue FJT B 301

鎖名	残基
B	ILE100
B	ALA101
B	LEU104
B	PHE105
B	GLN107
B	SER108
B	THR135
B	TYR138
C	ARG78
C	LEU79
C	GLU82
C	ILE84
C	TRP146
C	VAL148

site_id	AC4
残基数	11
詳細	binding site for residue FJT D 301

鎖名	残基
C	ILE100
C	ALA101
C	LEU104
C	PHE105
C	SER108
C	TYR138
D	LEU79
D	GLU82
D	ILE84
D	TRP146
D	VAL148

site_id	AC5
残基数	10
詳細	binding site for residue FJT D 302

鎖名	残基
D	ILE100
D	ALA101
D	LEU104
D	PHE105
D	SER108
D	TYR138
E	ARG78
E	LEU79
E	GLU82
E	TRP146

site_id	AC6
残基数	12
詳細	binding site for residue FJT E 301

鎖名	残基
E	ILE100
E	ALA101
E	LEU104
E	PHE105
E	SER108
E	TYR138
F	ARG78
F	LEU79
F	GLU82
F	ILE84
F	TRP146
F	VAL148

site_id	AC7
残基数	1
詳細	binding site for residue EDO E 302

鎖名	残基
E	LYS202

site_id	AC8
残基数	10
詳細	binding site for residue FJT F 301

鎖名	残基
F	ALA101
F	LEU104
F	PHE105
F	SER108
F	TYR138
G	LEU79
G	GLU82
G	ILE84
G	TRP146
G	VAL148

site_id	AC9
残基数	2
詳細	binding site for residue EDO F 302

鎖名	残基
F	GLN179
F	ILE198

site_id	AD1
残基数	10
詳細	binding site for residue FJT G 301

鎖名	残基
A	LEU79
A	GLU82
A	ILE84
A	TRP146
G	ILE100
G	ALA101
G	LEU104
G	PHE105
G	SER108
G	TYR138

site_id	AD2
残基数	11
詳細	binding site for residue FJT H 301

鎖名	残基
H	ARG78
H	LEU79
H	GLU82
H	TRP146
H	VAL148
N	ILE100
N	ALA101
N	LEU104
N	PHE105
N	SER108
N	TYR138

site_id	AD3
残基数	10
詳細	binding site for residue FJT H 302

鎖名	残基
H	GLN107
H	SER108
H	TYR138
I	LEU79
I	GLU82
I	ILE84
H	ILE100
H	ALA101
H	LEU104
H	PHE105

site_id	AD4
残基数	11
詳細	binding site for residue FJT J 301

鎖名	残基
I	ILE100
I	ALA101
I	LEU104
I	PHE105
I	SER108
I	TYR138
J	ARG78
J	LEU79
J	GLU82
J	TRP146
J	VAL148

site_id	AD5
残基数	13
詳細	binding site for residue FJT K 301

鎖名	残基
J	ALA101
J	LEU104
J	PHE105
J	SER108
J	TYR138
K	ARG78
K	LEU79
K	GLU82
K	ILE84
K	HIS116
K	ALA118
K	TRP146
K	VAL148

site_id	AD6
残基数	13
詳細	binding site for residue FJT L 301

鎖名	残基
K	LEU104
K	PHE105
K	SER108
K	THR135
K	TYR138
L	ARG78
L	LEU79
L	GLU82
L	ILE84
L	ALA118
L	TRP146
L	VAL148
L	LEU170

site_id	AD7
残基数	10
詳細	binding site for residue FJT M 301

鎖名	残基
L	ILE100
L	LEU104
L	PHE105
L	GLN107
L	SER108
M	LEU79
M	GLU82
M	ILE84
M	TRP146
M	VAL148

site_id	AD8
残基数	10
詳細	binding site for residue FJT M 302

鎖名	残基
M	ALA101
M	LEU104
M	PHE105
M	SER108
M	TYR138
N	LEU79
N	GLU82
N	ILE84
N	TRP146
N	VAL148

site_id	AD9
残基数	3
詳細	binding site for residue EDO N 301

鎖名	残基
N	GLN179
N	ILE198
N	LYS202

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00381
残基数	12
詳細	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TwcVGqAASMGS

鎖名	残基	詳細
A	THR145-SER156

site_id	PS00382
残基数	14
詳細	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RhslPnsrIMIHQP

鎖名	残基	詳細
A	ARG167-PRO180

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	14
詳細	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:11923310

鎖名	残基	詳細
A	SER153
B	SER153
C	SER153
D	SER153
E	SER153
F	SER153
G	SER153
H	SER153
I	SER153
J	SER153
K	SER153
L	SER153
M	SER153
N	SER153

site_id	SWS_FT_FI2
残基数	14
詳細	ACT_SITE: ACT_SITE => ECO:0000250

鎖名	残基	詳細
A	HIS178
B	HIS178
C	HIS178
D	HIS178
E	HIS178
F	HIS178
G	HIS178
H	HIS178
I	HIS178
J	HIS178
K	HIS178
L	HIS178
M	HIS178
N	HIS178

site_id	SWS_FT_FI3
残基数	14
詳細	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:O88696

鎖名	残基	詳細
A	LYS200
B	LYS200
C	LYS200
D	LYS200
E	LYS200
F	LYS200
G	LYS200
H	LYS200
I	LYS200
J	LYS200
K	LYS200
L	LYS200
M	LYS200
N	LYS200

site_id	SWS_FT_FI4
残基数	14
詳細	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

鎖名	残基	詳細
A	LYS211
B	LYS211
C	LYS211
D	LYS211
E	LYS211
F	LYS211
G	LYS211
H	LYS211
I	LYS211
J	LYS211
K	LYS211
L	LYS211
M	LYS211
N	LYS211

		Sequence (fasta)
		PDBx/mmCIF
		PDBML (ヘッダのみ (no-atom))
		PDB形式 (全ての情報)
		検証レポート (PDF)
		EDMap 2fo-fc (MTZ)