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6H1E

Crystal structure of C21orf127-TRMT112 in complex with SAH and H4 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0008168molecular_functionmethyltransferase activity
A0008276molecular_functionprotein methyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0009007molecular_functionsite-specific DNA-methyltransferase (adenine-specific) activity
A0009404biological_processtoxin metabolic process
A0016740molecular_functiontransferase activity
A0018364biological_processpeptidyl-glutamine methylation
A0018872biological_processarsonoacetate metabolic process
A0030307biological_processpositive regulation of cell growth
A0030792molecular_functionmethylarsonite methyltransferase activity
A0032259biological_processmethylation
A0032775biological_processobsolete DNA methylation on adenine
A0032991cellular_componentprotein-containing complex
A0035657cellular_componenteRF1 methyltransferase complex
A0036009molecular_functionprotein-glutamine N-methyltransferase activity
A0042054molecular_functionhistone methyltransferase activity
A0045814biological_processnegative regulation of gene expression, epigenetic
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0140984molecular_functionhistone H4K12 methyltransferase activity
A1904047molecular_functionS-adenosyl-L-methionine binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0008276molecular_functionprotein methyltransferase activity
B0018364biological_processpeptidyl-glutamine methylation
B0030488biological_processtRNA methylation
B0031167biological_processrRNA methylation
B0032991cellular_componentprotein-containing complex
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0046982molecular_functionprotein heterodimerization activity
B0048471cellular_componentperinuclear region of cytoplasm
B0070476biological_processrRNA (guanine-N7)-methylation
B0141106molecular_functiontRNA methyltransferase activator activity
B2000234biological_processpositive regulation of rRNA processing
S0000786cellular_componentnucleosome
S0003677molecular_functionDNA binding
S0030527molecular_functionstructural constituent of chromatin
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue SAH A 301
ChainResidue
ATYR23
ATHR102
AASP103
ALEU104
AASN122
AALA140
AARG154
AHOH406
AHOH412
AHOH414
AHOH420
ATHR29
AHOH425
SMLZ12
AGLU51
AGLY53
ASER54
AGLY55
AVAL59
AASP77
AILE78

Functional Information from PROSITE/UniProt
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
SGLY14-HIS18

site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. LVFNPPY
ChainResidueDetails
ALEU119-TYR125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
AASP103
ALEU104
AASN122
BSER120
AGLU51
AASP77

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER126

218500

건을2024-04-17부터공개중

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