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6H03

OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0004866molecular_functionendopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005579cellular_componentmembrane attack complex
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010760biological_processnegative regulation of macrophage chemotaxis
A0031640biological_processkilling of cells of another organism
A0032722biological_processpositive regulation of chemokine production
A0045087biological_processinnate immune response
A0050896biological_processresponse to stimulus
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
B0001701biological_processin utero embryonic development
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005579cellular_componentmembrane attack complex
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0006956biological_processcomplement activation
B0006958biological_processcomplement activation, classical pathway
B0031640biological_processkilling of cells of another organism
B0045087biological_processinnate immune response
B0050778biological_processpositive regulation of immune response
B0070062cellular_componentextracellular exosome
C0002376biological_processimmune system process
C0005576cellular_componentextracellular region
C0005579cellular_componentmembrane attack complex
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0006958biological_processcomplement activation, classical pathway
C0016020cellular_componentmembrane
C0031640biological_processkilling of cells of another organism
C0044877molecular_functionprotein-containing complex binding
C0045087biological_processinnate immune response
C0050778biological_processpositive regulation of immune response
C0070062cellular_componentextracellular exosome
C1903561cellular_componentextracellular vesicle
D0002376biological_processimmune system process
D0005576cellular_componentextracellular region
D0005579cellular_componentmembrane attack complex
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0031640biological_processkilling of cells of another organism
D0045087biological_processinnate immune response
D0050778biological_processpositive regulation of immune response
D0070062cellular_componentextracellular exosome
E0001848molecular_functioncomplement binding
E0002376biological_processimmune system process
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005579cellular_componentmembrane attack complex
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0006958biological_processcomplement activation, classical pathway
E0019841molecular_functionretinol binding
E0031640biological_processkilling of cells of another organism
E0044877molecular_functionprotein-containing complex binding
E0045087biological_processinnate immune response
E0050778biological_processpositive regulation of immune response
E0070062cellular_componentextracellular exosome
E0072562cellular_componentblood microparticle
F0001848molecular_functioncomplement binding
F0002376biological_processimmune system process
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005579cellular_componentmembrane attack complex
F0005615cellular_componentextracellular space
F0005886cellular_componentplasma membrane
F0006955biological_processimmune response
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0006958biological_processcomplement activation, classical pathway
F0016020cellular_componentmembrane
F0031640biological_processkilling of cells of another organism
F0044877molecular_functionprotein-containing complex binding
F0045087biological_processinnate immune response
F0050778biological_processpositive regulation of immune response
F0070062cellular_componentextracellular exosome
F0072562cellular_componentblood microparticle
G0001906biological_processcell killing
G0002376biological_processimmune system process
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005579cellular_componentmembrane attack complex
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006955biological_processimmune response
G0006956biological_processcomplement activation
G0006957biological_processcomplement activation, alternative pathway
G0006958biological_processcomplement activation, classical pathway
G0016020cellular_componentmembrane
G0031640biological_processkilling of cells of another organism
G0044218cellular_componentother organism cell membrane
G0045087biological_processinnate immune response
G0050778biological_processpositive regulation of immune response
G0051260biological_processprotein homooligomerization
G0070062cellular_componentextracellular exosome
G0072562cellular_componentblood microparticle
H0001906biological_processcell killing
H0002376biological_processimmune system process
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005579cellular_componentmembrane attack complex
H0005615cellular_componentextracellular space
H0005886cellular_componentplasma membrane
H0006955biological_processimmune response
H0006956biological_processcomplement activation
H0006957biological_processcomplement activation, alternative pathway
H0006958biological_processcomplement activation, classical pathway
H0016020cellular_componentmembrane
H0031640biological_processkilling of cells of another organism
H0044218cellular_componentother organism cell membrane
H0045087biological_processinnate immune response
H0050778biological_processpositive regulation of immune response
H0051260biological_processprotein homooligomerization
H0070062cellular_componentextracellular exosome
H0072562cellular_componentblood microparticle
I0001906biological_processcell killing
I0002376biological_processimmune system process
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005579cellular_componentmembrane attack complex
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0006955biological_processimmune response
I0006956biological_processcomplement activation
I0006957biological_processcomplement activation, alternative pathway
I0006958biological_processcomplement activation, classical pathway
I0016020cellular_componentmembrane
I0031640biological_processkilling of cells of another organism
I0044218cellular_componentother organism cell membrane
I0045087biological_processinnate immune response
I0050778biological_processpositive regulation of immune response
I0051260biological_processprotein homooligomerization
I0070062cellular_componentextracellular exosome
I0072562cellular_componentblood microparticle
J0001906biological_processcell killing
J0002376biological_processimmune system process
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005579cellular_componentmembrane attack complex
J0005615cellular_componentextracellular space
J0005886cellular_componentplasma membrane
J0006955biological_processimmune response
J0006956biological_processcomplement activation
J0006957biological_processcomplement activation, alternative pathway
J0006958biological_processcomplement activation, classical pathway
J0016020cellular_componentmembrane
J0031640biological_processkilling of cells of another organism
J0044218cellular_componentother organism cell membrane
J0045087biological_processinnate immune response
J0050778biological_processpositive regulation of immune response
J0051260biological_processprotein homooligomerization
J0070062cellular_componentextracellular exosome
J0072562cellular_componentblood microparticle
K0001906biological_processcell killing
K0002376biological_processimmune system process
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005579cellular_componentmembrane attack complex
K0005615cellular_componentextracellular space
K0005886cellular_componentplasma membrane
K0006955biological_processimmune response
K0006956biological_processcomplement activation
K0006957biological_processcomplement activation, alternative pathway
K0006958biological_processcomplement activation, classical pathway
K0016020cellular_componentmembrane
K0031640biological_processkilling of cells of another organism
K0044218cellular_componentother organism cell membrane
K0045087biological_processinnate immune response
K0050778biological_processpositive regulation of immune response
K0051260biological_processprotein homooligomerization
K0070062cellular_componentextracellular exosome
K0072562cellular_componentblood microparticle
L0001906biological_processcell killing
L0002376biological_processimmune system process
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005579cellular_componentmembrane attack complex
L0005615cellular_componentextracellular space
L0005886cellular_componentplasma membrane
L0006955biological_processimmune response
L0006956biological_processcomplement activation
L0006957biological_processcomplement activation, alternative pathway
L0006958biological_processcomplement activation, classical pathway
L0016020cellular_componentmembrane
L0031640biological_processkilling of cells of another organism
L0044218cellular_componentother organism cell membrane
L0045087biological_processinnate immune response
L0050778biological_processpositive regulation of immune response
L0051260biological_processprotein homooligomerization
L0070062cellular_componentextracellular exosome
L0072562cellular_componentblood microparticle
M0001906biological_processcell killing
M0002376biological_processimmune system process
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005579cellular_componentmembrane attack complex
M0005615cellular_componentextracellular space
M0005886cellular_componentplasma membrane
M0006955biological_processimmune response
M0006956biological_processcomplement activation
M0006957biological_processcomplement activation, alternative pathway
M0006958biological_processcomplement activation, classical pathway
M0016020cellular_componentmembrane
M0031640biological_processkilling of cells of another organism
M0044218cellular_componentother organism cell membrane
M0045087biological_processinnate immune response
M0050778biological_processpositive regulation of immune response
M0051260biological_processprotein homooligomerization
M0070062cellular_componentextracellular exosome
M0072562cellular_componentblood microparticle
N0001906biological_processcell killing
N0002376biological_processimmune system process
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005579cellular_componentmembrane attack complex
N0005615cellular_componentextracellular space
N0005886cellular_componentplasma membrane
N0006955biological_processimmune response
N0006956biological_processcomplement activation
N0006957biological_processcomplement activation, alternative pathway
N0006958biological_processcomplement activation, classical pathway
N0016020cellular_componentmembrane
N0031640biological_processkilling of cells of another organism
N0044218cellular_componentother organism cell membrane
N0045087biological_processinnate immune response
N0050778biological_processpositive regulation of immune response
N0051260biological_processprotein homooligomerization
N0070062cellular_componentextracellular exosome
N0072562cellular_componentblood microparticle
O0001906biological_processcell killing
O0002376biological_processimmune system process
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005579cellular_componentmembrane attack complex
O0005615cellular_componentextracellular space
O0005886cellular_componentplasma membrane
O0006955biological_processimmune response
O0006956biological_processcomplement activation
O0006957biological_processcomplement activation, alternative pathway
O0006958biological_processcomplement activation, classical pathway
O0016020cellular_componentmembrane
O0031640biological_processkilling of cells of another organism
O0044218cellular_componentother organism cell membrane
O0045087biological_processinnate immune response
O0050778biological_processpositive regulation of immune response
O0051260biological_processprotein homooligomerization
O0070062cellular_componentextracellular exosome
O0072562cellular_componentblood microparticle
P0001906biological_processcell killing
P0002376biological_processimmune system process
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005579cellular_componentmembrane attack complex
P0005615cellular_componentextracellular space
P0005886cellular_componentplasma membrane
P0006955biological_processimmune response
P0006956biological_processcomplement activation
P0006957biological_processcomplement activation, alternative pathway
P0006958biological_processcomplement activation, classical pathway
P0016020cellular_componentmembrane
P0031640biological_processkilling of cells of another organism
P0044218cellular_componentother organism cell membrane
P0045087biological_processinnate immune response
P0050778biological_processpositive regulation of immune response
P0051260biological_processprotein homooligomerization
P0070062cellular_componentextracellular exosome
P0072562cellular_componentblood microparticle
Q0001906biological_processcell killing
Q0002376biological_processimmune system process
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005579cellular_componentmembrane attack complex
Q0005615cellular_componentextracellular space
Q0005886cellular_componentplasma membrane
Q0006955biological_processimmune response
Q0006956biological_processcomplement activation
Q0006957biological_processcomplement activation, alternative pathway
Q0006958biological_processcomplement activation, classical pathway
Q0016020cellular_componentmembrane
Q0031640biological_processkilling of cells of another organism
Q0044218cellular_componentother organism cell membrane
Q0045087biological_processinnate immune response
Q0050778biological_processpositive regulation of immune response
Q0051260biological_processprotein homooligomerization
Q0070062cellular_componentextracellular exosome
Q0072562cellular_componentblood microparticle
R0001906biological_processcell killing
R0002376biological_processimmune system process
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005579cellular_componentmembrane attack complex
R0005615cellular_componentextracellular space
R0005886cellular_componentplasma membrane
R0006955biological_processimmune response
R0006956biological_processcomplement activation
R0006957biological_processcomplement activation, alternative pathway
R0006958biological_processcomplement activation, classical pathway
R0016020cellular_componentmembrane
R0031640biological_processkilling of cells of another organism
R0044218cellular_componentother organism cell membrane
R0045087biological_processinnate immune response
R0050778biological_processpositive regulation of immune response
R0051260biological_processprotein homooligomerization
R0070062cellular_componentextracellular exosome
R0072562cellular_componentblood microparticle
S0001906biological_processcell killing
S0002376biological_processimmune system process
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005579cellular_componentmembrane attack complex
S0005615cellular_componentextracellular space
S0005886cellular_componentplasma membrane
S0006955biological_processimmune response
S0006956biological_processcomplement activation
S0006957biological_processcomplement activation, alternative pathway
S0006958biological_processcomplement activation, classical pathway
S0016020cellular_componentmembrane
S0031640biological_processkilling of cells of another organism
S0044218cellular_componentother organism cell membrane
S0045087biological_processinnate immune response
S0050778biological_processpositive regulation of immune response
S0051260biological_processprotein homooligomerization
S0070062cellular_componentextracellular exosome
S0072562cellular_componentblood microparticle
T0001906biological_processcell killing
T0002376biological_processimmune system process
T0005515molecular_functionprotein binding
T0005576cellular_componentextracellular region
T0005579cellular_componentmembrane attack complex
T0005615cellular_componentextracellular space
T0005886cellular_componentplasma membrane
T0006955biological_processimmune response
T0006956biological_processcomplement activation
T0006957biological_processcomplement activation, alternative pathway
T0006958biological_processcomplement activation, classical pathway
T0016020cellular_componentmembrane
T0031640biological_processkilling of cells of another organism
T0044218cellular_componentother organism cell membrane
T0045087biological_processinnate immune response
T0050778biological_processpositive regulation of immune response
T0051260biological_processprotein homooligomerization
T0070062cellular_componentextracellular exosome
T0072562cellular_componentblood microparticle
U0001906biological_processcell killing
U0002376biological_processimmune system process
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005579cellular_componentmembrane attack complex
U0005615cellular_componentextracellular space
U0005886cellular_componentplasma membrane
U0006955biological_processimmune response
U0006956biological_processcomplement activation
U0006957biological_processcomplement activation, alternative pathway
U0006958biological_processcomplement activation, classical pathway
U0016020cellular_componentmembrane
U0031640biological_processkilling of cells of another organism
U0044218cellular_componentother organism cell membrane
U0045087biological_processinnate immune response
U0050778biological_processpositive regulation of immune response
U0051260biological_processprotein homooligomerization
U0070062cellular_componentextracellular exosome
U0072562cellular_componentblood microparticle
V0001906biological_processcell killing
V0002376biological_processimmune system process
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005579cellular_componentmembrane attack complex
V0005615cellular_componentextracellular space
V0005886cellular_componentplasma membrane
V0006955biological_processimmune response
V0006956biological_processcomplement activation
V0006957biological_processcomplement activation, alternative pathway
V0006958biological_processcomplement activation, classical pathway
V0016020cellular_componentmembrane
V0031640biological_processkilling of cells of another organism
V0044218cellular_componentother organism cell membrane
V0045087biological_processinnate immune response
V0050778biological_processpositive regulation of immune response
V0051260biological_processprotein homooligomerization
V0070062cellular_componentextracellular exosome
V0072562cellular_componentblood microparticle
W0001906biological_processcell killing
W0002376biological_processimmune system process
W0005515molecular_functionprotein binding
W0005576cellular_componentextracellular region
W0005579cellular_componentmembrane attack complex
W0005615cellular_componentextracellular space
W0005886cellular_componentplasma membrane
W0006955biological_processimmune response
W0006956biological_processcomplement activation
W0006957biological_processcomplement activation, alternative pathway
W0006958biological_processcomplement activation, classical pathway
W0016020cellular_componentmembrane
W0031640biological_processkilling of cells of another organism
W0044218cellular_componentother organism cell membrane
W0045087biological_processinnate immune response
W0050778biological_processpositive regulation of immune response
W0051260biological_processprotein homooligomerization
W0070062cellular_componentextracellular exosome
W0072562cellular_componentblood microparticle
X0001906biological_processcell killing
X0002376biological_processimmune system process
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005579cellular_componentmembrane attack complex
X0005615cellular_componentextracellular space
X0005886cellular_componentplasma membrane
X0006955biological_processimmune response
X0006956biological_processcomplement activation
X0006957biological_processcomplement activation, alternative pathway
X0006958biological_processcomplement activation, classical pathway
X0016020cellular_componentmembrane
X0031640biological_processkilling of cells of another organism
X0044218cellular_componentother organism cell membrane
X0045087biological_processinnate immune response
X0050778biological_processpositive regulation of immune response
X0051260biological_processprotein homooligomerization
X0070062cellular_componentextracellular exosome
X0072562cellular_componentblood microparticle
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CvCqsGtyGEnC
ChainResidueDetails
GCYS507-CYS518
DCYS475-CYS486
BCYS541-CYS552
CCYS469-CYS480
FCYS487-CYS498

site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C
ChainResidueDetails
GCYS91-CYS113
DCYS96-CYS119
CCYS79-CYS101
BCYS151-CYS173
FCYS78-CYS100

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. ClCacPFkfegia..C
ChainResidueDetails
GCYS505-CYS518
DCYS713-CYS728

site_idPS00279
Number of Residues12
DetailsMACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY
ChainResidueDetails
GTYR314-TYR325
DTYR292-TYR303
BTYR354-TYR365
CTYR279-TYR290
FTYR300-TYR311

site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV
ChainResidueDetails
EASN21-VAL34

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues630
DetailsTRANSMEM: Beta stranded => ECO:0000255
ChainResidueDetails
GVAL293-TYR309
GTYR314-GLY333
PVAL293-TYR309
PTYR314-GLY333
HVAL293-TYR309
HTYR314-GLY333
IVAL293-TYR309
ITYR314-GLY333
JVAL293-TYR309
JTYR314-GLY333
KVAL293-TYR309
KTYR314-GLY333
LVAL293-TYR309
LTYR314-GLY333
MVAL293-TYR309
MTYR314-GLY333
NVAL293-TYR309
NTYR314-GLY333
OVAL293-TYR309
OTYR314-GLY333
QVAL293-TYR309
QTYR314-GLY333
RVAL293-TYR309
RTYR314-GLY333
SVAL293-TYR309
STYR314-GLY333
TVAL293-TYR309
TTYR314-GLY333
UVAL293-TYR309
UTYR314-GLY333
VVAL293-TYR309
VTYR314-GLY333
WVAL293-TYR309
WTYR314-GLY333
XVAL293-TYR309
XTYR314-GLY333

site_idSWS_FT_FI2
Number of Residues18
DetailsSITE: Cleavage; by thrombin
ChainResidueDetails
GHIS244
PHIS244
HHIS244
IHIS244
JHIS244
KHIS244
LHIS244
MHIS244
NHIS244
OHIS244
QHIS244
RHIS244
SHIS244
THIS244
UHIS244
VHIS244
WHIS244
XHIS244

site_idSWS_FT_FI3
Number of Residues18
DetailsCARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839
ChainResidueDetails
GTRP27
PTRP27
HTRP27
ITRP27
JTRP27
KTRP27
LTRP27
MTRP27
NTRP27
OTRP27
QTRP27
RTRP27
STRP27
TTRP27
UTRP27
VTRP27
WTRP27
XTRP27

site_idSWS_FT_FI4
Number of Residues18
DetailsCARBOHYD: C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839
ChainResidueDetails
GTRP30
PTRP30
HTRP30
ITRP30
JTRP30
KTRP30
LTRP30
MTRP30
NTRP30
OTRP30
QTRP30
RTRP30
STRP30
TTRP30
UTRP30
VTRP30
WTRP30
XTRP30

site_idSWS_FT_FI5
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
ChainResidueDetails
GASN256
PASN256
HASN256
IASN256
JASN256
KASN256
LASN256
MASN256
NASN256
OASN256
QASN256
RASN256
SASN256
TASN256
UASN256
VASN256
WASN256
XASN256

site_idSWS_FT_FI6
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
ChainResidueDetails
GASN394
PASN394
HASN394
IASN394
JASN394
KASN394
LASN394
MASN394
NASN394
OASN394
QASN394
RASN394
SASN394
TASN394
UASN394
VASN394
WASN394
XASN394

218500

PDB entries from 2024-04-17

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