Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GH1

HLA-E*01:03 in complex with Mtb44

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002376	biological_process	immune system process
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032092	biological_process	positive regulation of protein binding
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1900121	biological_process	negative regulation of receptor binding
F	1900122	biological_process	positive regulation of receptor binding
F	1904434	biological_process	positive regulation of ferrous iron binding
F	1904437	biological_process	positive regulation of transferrin receptor binding
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002376	biological_process	immune system process
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010977	biological_process	negative regulation of neuron projection development
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0032092	biological_process	positive regulation of protein binding
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1900121	biological_process	negative regulation of receptor binding
H	1900122	biological_process	positive regulation of receptor binding
H	1904434	biological_process	positive regulation of ferrous iron binding
H	1904437	biological_process	positive regulation of transferrin receptor binding
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG21
B	HIS52

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG75
A	ARG79
A	ARG82
G	ARG75

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
G	ARG75
G	ARG82
A	ARG75
A	HOH402
A	HOH463

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 C 301

Chain	Residue
C	ARG62
C	GLU166
C	TRP167
Q	ARG1

site_id	AC5
Number of Residues	8
Details	binding site for residue SO4 C 302

Chain	Residue
A	GLY223
A	HIS224
C	SER42
C	ARG44
C	ARG68
C	HOH408
C	HOH437
C	HOH449

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG75
C	ARG79
C	ARG82
C	HOH407
E	ARG75

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 Q 101

Chain	Residue
C	TYR159
C	THR163
Q	ARG1
Q	PRO3
Q	ALA4
Q	HOH201
Q	HOH203
Q	HOH205

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 E 301

Chain	Residue
E	ARG21
E	HOH465
F	HIS52

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 F 201

Chain	Residue
F	ARG13
F	HIS14
F	HOH325
F	HOH327

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 F 202

Chain	Residue
E	GLY1
E	HIS3
E	LEU180
F	ASN84

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 G 301

Chain	Residue
E	THR214
E	THR216
E	HOH496
G	ARG44
G	ARG68
G	HOH419
G	HOH442
G	HOH465

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN G 302

Chain	Residue
C	HIS181
C	GLU183
G	HIS181
G	GLU183

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 Z 101

Chain	Residue
Z	ARG1
Z	PRO3
Z	ALA4
Z	HOH201
Z	HOH203

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR79-HIS85
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN3
D	GLN3
F	GLN3
H	GLN3

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE2
D	ILE2
F	ILE2
H	ILE2

site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS20
B	LYS42
B	LYS49
B	LYS59
B	LYS92
B	LYS95
D	LYS20
D	LYS42
D	LYS49
D	LYS59
D	LYS92
D	LYS95
F	LYS20
F	LYS42
F	LYS49
F	LYS59
F	LYS92
F	LYS95
H	LYS20
H	LYS42
H	LYS49
H	LYS59
H	LYS92
H	LYS95

site_id	SWS_FT_FI4
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:18339401

Chain	Residue	Details
A	ASN77
A	TYR84
A	SER143
A	LYS146
A	GLN156
A	TYR159
A	TYR171
C	ASN77
C	TYR84
C	SER143
C	LYS146
C	GLN156
C	TYR159
C	TYR171
E	ASN77
E	TYR84
E	SER143
E	LYS146
E	GLN156
E	TYR159
E	TYR171
G	ASN77
G	TYR84
G	SER143
G	LYS146
G	GLN156
G	TYR159
G	TYR171

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19349973

Chain	Residue	Details
A	ASN86
C	ASN86
E	ASN86
G	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)