6GGH
Human jak1 kinase domain in complex with inhibitor
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 20 |
| 詳細 | binding site for residue EYQ A 1201 |
| 鎖名 | 残基 |
| A | LEU881 |
| A | GLU966 |
| A | ASP1003 |
| A | ARG1007 |
| A | ASN1008 |
| A | LEU1010 |
| A | GLY1020 |
| A | ASP1021 |
| A | HOH1344 |
| A | HOH1358 |
| A | HOH1381 |
| A | GLY882 |
| A | HOH1412 |
| A | VAL889 |
| A | ALA906 |
| A | GLU957 |
| A | PHE958 |
| A | LEU959 |
| A | PRO960 |
| A | GLY962 |
| site_id | AC2 |
| 残基数 | 19 |
| 詳細 | binding site for residue EYQ B 1201 |
| 鎖名 | 残基 |
| B | LEU881 |
| B | GLY882 |
| B | ALA906 |
| B | GLU957 |
| B | PHE958 |
| B | LEU959 |
| B | PRO960 |
| B | GLY962 |
| B | GLU966 |
| B | ASP1003 |
| B | ARG1007 |
| B | ASN1008 |
| B | LEU1010 |
| B | GLY1020 |
| B | ASP1021 |
| B | ASP1042 |
| B | HOH1316 |
| B | HOH1362 |
| B | HOH1430 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| 鎖名 | 残基 | 詳細 |
| A | ASP1003 | |
| B | ASP1003 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| 鎖名 | 残基 | 詳細 |
| A | LEU881 | |
| B | LEU881 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333 |
| 鎖名 | 残基 | 詳細 |
| A | LYS908 | |
| B | LYS908 |
| site_id | SWS_FT_FI4 |
| 残基数 | 4 |
| 詳細 | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529 |
| 鎖名 | 残基 | 詳細 |
| A | PTR1034 | |
| A | PTR1035 | |
| B | PTR1034 | |
| B | PTR1035 |
