6GGD

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005783cellular_componentendoplasmic reticulum
A0005759cellular_componentmitochondrial matrix
A0005739cellular_componentmitochondrion
A0000790cellular_componentnuclear chromatin
A0016363cellular_componentnuclear matrix
A0005730cellular_componentnucleolus
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0016605cellular_componentPML body
A0032991cellular_componentprotein-containing complex
A0005657cellular_componentreplication fork
A0035861cellular_componentsite of double-strand break
A0005667cellular_componenttranscription factor complex
A0005524molecular_functionATP binding
A0051087molecular_functionchaperone binding
A0003682molecular_functionchromatin binding
A0005507molecular_functioncopper ion binding
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0097718molecular_functiondisordered domain specific binding
A0003677molecular_functionDNA binding
A0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
A0003700molecular_functionDNA-binding transcription factor activity
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0019899molecular_functionenzyme binding
A0035035molecular_functionhistone acetyltransferase binding
A0042826molecular_functionhistone deacetylase binding
A0035033molecular_functionhistone deacetylase regulator activity
A0042802molecular_functionidentical protein binding
A0097371molecular_functionMDM2/MDM4 family protein binding
A0003730molecular_functionmRNA 3'-UTR binding
A0002039molecular_functionp53 binding
A1990841molecular_functionpromoter-specific chromatin binding
A0002020molecular_functionprotease binding
A0046982molecular_functionprotein heterodimerization activity
A0042803molecular_functionprotein homodimerization activity
A0019901molecular_functionprotein kinase binding
A0047485molecular_functionprotein N-terminus binding
A0051721molecular_functionprotein phosphatase 2A binding
A0019903molecular_functionprotein phosphatase binding
A0043621molecular_functionprotein self-association
A0030971molecular_functionreceptor tyrosine kinase binding
A0000980molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding
A0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
A0001085molecular_functionRNA polymerase II transcription factor binding
A0001094molecular_functionTFIID-class transcription factor complex binding
A0008134molecular_functiontranscription factor binding
A0044212molecular_functiontranscription regulatory region DNA binding
A0031625molecular_functionubiquitin protein ligase binding
A0008270molecular_functionzinc ion binding
A0006914biological_processautophagy
A0002326biological_processB cell lineage commitment
A0006284biological_processbase-excision repair
A0048539biological_processbone marrow development
A0060411biological_processcardiac septum morphogenesis
A0007569biological_processcell aging
A0007050biological_processcell cycle arrest
A0030154biological_processcell differentiation
A0008283biological_processcell proliferation
A0034613biological_processcellular protein localization
A0072717biological_processcellular response to actinomycin D
A0006974biological_processcellular response to DNA damage stimulus
A0035690biological_processcellular response to drug
A0071480biological_processcellular response to gamma radiation
A0042149biological_processcellular response to glucose starvation
A0071456biological_processcellular response to hypoxia
A0071479biological_processcellular response to ionizing radiation
A0034644biological_processcellular response to UV
A0071494biological_processcellular response to UV-C
A0021549biological_processcerebellum development
A0031497biological_processchromatin assembly
A0048512biological_processcircadian behavior
A0019221biological_processcytokine-mediated signaling pathway
A0008340biological_processdetermination of adult lifespan
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A0006978biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
A0000733biological_processDNA strand renaturation
A0006302biological_processdouble-strand break repair
A0048568biological_processembryonic organ development
A0043153biological_processentrainment of circadian clock by photoperiod
A0006983biological_processER overload response
A0007369biological_processgastrulation
A0002244biological_processhematopoietic progenitor cell differentiation
A0060218biological_processhematopoietic stem cell differentiation
A0001701biological_processin utero embryonic development
A0060333biological_processinterferon-gamma-mediated signaling pathway
A0097193biological_processintrinsic apoptotic signaling pathway
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A1990144biological_processintrinsic apoptotic signaling pathway in response to hypoxia
A0043504biological_processmitochondrial DNA repair
A0071850biological_processmitotic cell cycle arrest
A0031571biological_processmitotic G1 DNA damage checkpoint
A0009299biological_processmRNA transcription
A0007275biological_processmulticellular organism development
A0035264biological_processmulticellular organism growth
A0070266biological_processnecroptotic process
A0043066biological_processnegative regulation of apoptotic process
A0030308biological_processnegative regulation of cell growth
A0008285biological_processnegative regulation of cell proliferation
A0008156biological_processnegative regulation of DNA replication
A0048147biological_processnegative regulation of fibroblast proliferation
A1904024biological_processnegative regulation of glucose catabolic process to lactate via pyruvate
A0051097biological_processnegative regulation of helicase activity
A1901525biological_processnegative regulation of mitophagy
A0007406biological_processnegative regulation of neuroblast proliferation
A1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
A0045861biological_processnegative regulation of proteolysis
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
A0051974biological_processnegative regulation of telomerase activity
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0045892biological_processnegative regulation of transcription, DNA-templated
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0051402biological_processneuron apoptotic process
A0006289biological_processnucleotide-excision repair
A0097252biological_processoligodendrocyte apoptotic process
A0090403biological_processoxidative stress-induced premature senescence
A0043065biological_processpositive regulation of apoptotic process
A0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
A0090343biological_processpositive regulation of cell aging
A0071158biological_processpositive regulation of cell cycle arrest
A1900119biological_processpositive regulation of execution phase of apoptosis
A0010628biological_processpositive regulation of gene expression
A0031065biological_processpositive regulation of histone deacetylation
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
A0035794biological_processpositive regulation of mitochondrial membrane permeability
A0043525biological_processpositive regulation of neuron apoptotic process
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A1902895biological_processpositive regulation of pri-miRNA transcription by RNA polymerase II
A1903800biological_processpositive regulation of production of miRNAs involved in gene silencing by miRNA
A0062100
A0046827biological_processpositive regulation of protein export from nucleus
A1900740biological_processpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
A0032461biological_processpositive regulation of protein oligomerization
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
A0070245biological_processpositive regulation of thymocyte apoptotic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A1990440biological_processpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
A0061419biological_processpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
A0045893biological_processpositive regulation of transcription, DNA-templated
A0016579biological_processprotein deubiquitination
A0051289biological_processprotein homotetramerization
A0006606biological_processprotein import into nucleus
A0008104biological_processprotein localization
A0050821biological_processprotein stabilization
A0051262biological_processprotein tetramerization
A0065003biological_processprotein-containing complex assembly
A0007265biological_processRas protein signal transduction
A0042981biological_processregulation of apoptotic process
A1902749biological_processregulation of cell cycle G2/M phase transition
A2000772biological_processregulation of cellular senescence
A0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
A2000269biological_processregulation of fibroblast apoptotic process
A0072363biological_processregulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
A1902253biological_processregulation of intrinsic apoptotic signaling pathway by p53 class mediator
A0046902biological_processregulation of mitochondrial membrane permeability
A1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
A1901796biological_processregulation of signal transduction by p53 class mediator
A0034103biological_processregulation of tissue remodeling
A0006355biological_processregulation of transcription, DNA-templated
A0001836biological_processrelease of cytochrome c from mitochondria
A0090399biological_processreplicative senescence
A0046677biological_processresponse to antibiotic
A0010332biological_processresponse to gamma radiation
A0002931biological_processresponse to ischemia
A0009651biological_processresponse to salt stress
A0010165biological_processresponse to X-ray
A0051123biological_processRNA polymerase II preinitiation complex assembly
A0009303biological_processrRNA transcription
A0072331biological_processsignal transduction by p53 class mediator
A0001756biological_processsomitogenesis
A0033077biological_processT cell differentiation in thymus
A0002360biological_processT cell lineage commitment
A0002309biological_processT cell proliferation involved in immune response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0016032biological_processviral process
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005783cellular_componentendoplasmic reticulum
B0005759cellular_componentmitochondrial matrix
B0005739cellular_componentmitochondrion
B0000790cellular_componentnuclear chromatin
B0016363cellular_componentnuclear matrix
B0005730cellular_componentnucleolus
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0016605cellular_componentPML body
B0032991cellular_componentprotein-containing complex
B0005657cellular_componentreplication fork
B0035861cellular_componentsite of double-strand break
B0005667cellular_componenttranscription factor complex
B0005524molecular_functionATP binding
B0051087molecular_functionchaperone binding
B0003682molecular_functionchromatin binding
B0005507molecular_functioncopper ion binding
B0001046molecular_functioncore promoter sequence-specific DNA binding
B0097718molecular_functiondisordered domain specific binding
B0003677molecular_functionDNA binding
B0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
B0003700molecular_functionDNA-binding transcription factor activity
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0019899molecular_functionenzyme binding
B0035035molecular_functionhistone acetyltransferase binding
B0042826molecular_functionhistone deacetylase binding
B0035033molecular_functionhistone deacetylase regulator activity
B0042802molecular_functionidentical protein binding
B0097371molecular_functionMDM2/MDM4 family protein binding
B0003730molecular_functionmRNA 3'-UTR binding
B0002039molecular_functionp53 binding
B1990841molecular_functionpromoter-specific chromatin binding
B0002020molecular_functionprotease binding
B0046982molecular_functionprotein heterodimerization activity
B0042803molecular_functionprotein homodimerization activity
B0019901molecular_functionprotein kinase binding
B0047485molecular_functionprotein N-terminus binding
B0051721molecular_functionprotein phosphatase 2A binding
B0019903molecular_functionprotein phosphatase binding
B0043621molecular_functionprotein self-association
B0030971molecular_functionreceptor tyrosine kinase binding
B0000980molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding
B0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
B0001085molecular_functionRNA polymerase II transcription factor binding
B0001094molecular_functionTFIID-class transcription factor complex binding
B0008134molecular_functiontranscription factor binding
B0044212molecular_functiontranscription regulatory region DNA binding
B0031625molecular_functionubiquitin protein ligase binding
B0008270molecular_functionzinc ion binding
B0006914biological_processautophagy
B0002326biological_processB cell lineage commitment
B0006284biological_processbase-excision repair
B0048539biological_processbone marrow development
B0060411biological_processcardiac septum morphogenesis
B0007569biological_processcell aging
B0007050biological_processcell cycle arrest
B0030154biological_processcell differentiation
B0008283biological_processcell proliferation
B0034613biological_processcellular protein localization
B0072717biological_processcellular response to actinomycin D
B0006974biological_processcellular response to DNA damage stimulus
B0035690biological_processcellular response to drug
B0071480biological_processcellular response to gamma radiation
B0042149biological_processcellular response to glucose starvation
B0071456biological_processcellular response to hypoxia
B0071479biological_processcellular response to ionizing radiation
B0034644biological_processcellular response to UV
B0071494biological_processcellular response to UV-C
B0021549biological_processcerebellum development
B0031497biological_processchromatin assembly
B0048512biological_processcircadian behavior
B0019221biological_processcytokine-mediated signaling pathway
B0008340biological_processdetermination of adult lifespan
B0030330biological_processDNA damage response, signal transduction by p53 class mediator
B0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
B0006978biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
B0000733biological_processDNA strand renaturation
B0006302biological_processdouble-strand break repair
B0048568biological_processembryonic organ development
B0043153biological_processentrainment of circadian clock by photoperiod
B0006983biological_processER overload response
B0007369biological_processgastrulation
B0002244biological_processhematopoietic progenitor cell differentiation
B0060218biological_processhematopoietic stem cell differentiation
B0001701biological_processin utero embryonic development
B0060333biological_processinterferon-gamma-mediated signaling pathway
B0097193biological_processintrinsic apoptotic signaling pathway
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B1990144biological_processintrinsic apoptotic signaling pathway in response to hypoxia
B0043504biological_processmitochondrial DNA repair
B0071850biological_processmitotic cell cycle arrest
B0031571biological_processmitotic G1 DNA damage checkpoint
B0009299biological_processmRNA transcription
B0007275biological_processmulticellular organism development
B0035264biological_processmulticellular organism growth
B0070266biological_processnecroptotic process
B0043066biological_processnegative regulation of apoptotic process
B0030308biological_processnegative regulation of cell growth
B0008285biological_processnegative regulation of cell proliferation
B0008156biological_processnegative regulation of DNA replication
B0048147biological_processnegative regulation of fibroblast proliferation
B1904024biological_processnegative regulation of glucose catabolic process to lactate via pyruvate
B0051097biological_processnegative regulation of helicase activity
B1901525biological_processnegative regulation of mitophagy
B0007406biological_processnegative regulation of neuroblast proliferation
B1903799biological_processnegative regulation of production of miRNAs involved in gene silencing by miRNA
B0045861biological_processnegative regulation of proteolysis
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0051974biological_processnegative regulation of telomerase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0045892biological_processnegative regulation of transcription, DNA-templated
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0051402biological_processneuron apoptotic process
B0006289biological_processnucleotide-excision repair
B0097252biological_processoligodendrocyte apoptotic process
B0090403biological_processoxidative stress-induced premature senescence
B0043065biological_processpositive regulation of apoptotic process
B0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
B0090343biological_processpositive regulation of cell aging
B0071158biological_processpositive regulation of cell cycle arrest
B1900119biological_processpositive regulation of execution phase of apoptosis
B0010628biological_processpositive regulation of gene expression
B0031065biological_processpositive regulation of histone deacetylation
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0035794biological_processpositive regulation of mitochondrial membrane permeability
B0043525biological_processpositive regulation of neuron apoptotic process
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B1902895biological_processpositive regulation of pri-miRNA transcription by RNA polymerase II
B1903800biological_processpositive regulation of production of miRNAs involved in gene silencing by miRNA
B0062100
B0046827biological_processpositive regulation of protein export from nucleus
B1900740biological_processpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
B0032461biological_processpositive regulation of protein oligomerization
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0090200biological_processpositive regulation of release of cytochrome c from mitochondria
B0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
B0070245biological_processpositive regulation of thymocyte apoptotic process
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B1990440biological_processpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
B0061419biological_processpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
B0045893biological_processpositive regulation of transcription, DNA-templated
B0016579biological_processprotein deubiquitination
B0051289biological_processprotein homotetramerization
B0006606biological_processprotein import into nucleus
B0008104biological_processprotein localization
B0050821biological_processprotein stabilization
B0051262biological_processprotein tetramerization
B0065003biological_processprotein-containing complex assembly
B0007265biological_processRas protein signal transduction
B0042981biological_processregulation of apoptotic process
B1902749biological_processregulation of cell cycle G2/M phase transition
B2000772biological_processregulation of cellular senescence
B0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
B2000269biological_processregulation of fibroblast apoptotic process
B0072363biological_processregulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
B1902253biological_processregulation of intrinsic apoptotic signaling pathway by p53 class mediator
B0046902biological_processregulation of mitochondrial membrane permeability
B1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
B1901796biological_processregulation of signal transduction by p53 class mediator
B0034103biological_processregulation of tissue remodeling
B0006355biological_processregulation of transcription, DNA-templated
B0001836biological_processrelease of cytochrome c from mitochondria
B0090399biological_processreplicative senescence
B0046677biological_processresponse to antibiotic
B0010332biological_processresponse to gamma radiation
B0002931biological_processresponse to ischemia
B0009651biological_processresponse to salt stress
B0010165biological_processresponse to X-ray
B0051123biological_processRNA polymerase II preinitiation complex assembly
B0009303biological_processrRNA transcription
B0072331biological_processsignal transduction by p53 class mediator
B0001756biological_processsomitogenesis
B0033077biological_processT cell differentiation in thymus
B0002360biological_processT cell lineage commitment
B0002309biological_processT cell proliferation involved in immune response
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0016032biological_processviral process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN A 401
ChainResidue
ACYS176
AHIS179
ACYS238
ACYS242

AC211binding site for residue EYB A 402
ChainResidue
ALEU145
AVAL147
ATHR150
APRO151
ACYS220
AGLU221
APRO222
APRO223
AASP228
ATHR230
AHOH582

AC34binding site for residue ZN B 401
ChainResidue
BCYS176
BHIS179
BCYS238
BCYS242

AC412binding site for residue EYB B 402
ChainResidue
BLEU145
BVAL147
BTHR150
BPRO151
BCYS220
BGLU221
BPRO222
BPRO223
BASP228
BTHR230
BHOH642
BHOH653

AC56binding site for residue GOL B 403
ChainResidue
BARG174
BGLN192
BASP207
BPHE212
BHIS214
BHOH535

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
EYB_6ggd_A_40215[9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
ChainResidueligand
ALEU145-VAL147EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
ATHR150-PRO153EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
ACYS220-PRO223EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
ASER227-THR230EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium

EYB_6ggd_B_40216[9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium binding site
ChainResidueligand
BLEU145-VAL147EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
BTHR150-THR155EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
BCYS220-PRO223EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium
BASP228-THR230EYB: [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium

GOL_6ggd_B_4038GLYCEROL binding site
ChainResidueligand
BVAL172GOL: GLYCEROL
BARG174GOL: GLYCEROL
BGLN192GOL: GLYCEROL
BASP207-ASP208GOL: GLYCEROL
BPHE212-HIS214GOL: GLYCEROL

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails