6D83

Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0002090	biological_process	regulation of receptor internalization
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006886	biological_process	intracellular protein transport
C	0012505	cellular_component	endomembrane system
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0031252	cellular_component	cell leading edge
C	0032991	cellular_component	protein-containing complex
C	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0060292	biological_process	long-term synaptic depression
C	0070062	cellular_component	extracellular exosome
C	0097061	biological_process	dendritic spine organization
C	0098586	biological_process	cellular response to virus
C	1990386	biological_process	mitotic cleavage furrow ingression
G	0006886	biological_process	intracellular protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0002090	biological_process	regulation of receptor internalization
H	0003723	molecular_function	RNA binding
H	0003924	molecular_function	GTPase activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006886	biological_process	intracellular protein transport
H	0012505	cellular_component	endomembrane system
H	0014069	cellular_component	postsynaptic density
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0016192	biological_process	vesicle-mediated transport
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030017	cellular_component	sarcomere
H	0031252	cellular_component	cell leading edge
H	0032991	cellular_component	protein-containing complex
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0043005	cellular_component	neuron projection
H	0045202	cellular_component	synapse
H	0060292	biological_process	long-term synaptic depression
H	0070062	cellular_component	extracellular exosome
H	0097061	biological_process	dendritic spine organization
H	0098586	biological_process	cellular response to virus
H	1990386	biological_process	mitotic cleavage furrow ingression
L	0005102	molecular_function	signaling receptor binding
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005576	cellular_component	extracellular region
L	0016020	cellular_component	membrane
L	0017124	molecular_function	SH3 domain binding
L	0019049	biological_process	virus-mediated perturbation of host defense response
L	0019058	biological_process	viral life cycle
L	0019901	molecular_function	protein kinase binding
L	0020002	cellular_component	host cell plasma membrane
L	0031996	molecular_function	thioesterase binding
L	0033644	cellular_component	host cell membrane
L	0033668	biological_process	symbiont-mediated suppression of host apoptosis
L	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
L	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
L	0039521	biological_process	suppression by virus of host autophagy
L	0042288	molecular_function	MHC class I protein binding
L	0042609	molecular_function	CD4 receptor binding
L	0044177	cellular_component	host cell Golgi apparatus
L	0044178	cellular_component	host cell Golgi membrane
L	0044423	cellular_component	virion component
L	0045225	biological_process	negative regulation of CD4 production
L	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0051117	molecular_function	ATPase binding
L	0070206	biological_process	protein trimerization
L	0075528	biological_process	perturbation by virus of host immune response
M	0005515	molecular_function	protein binding
M	0005765	cellular_component	lysosomal membrane
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0005802	cellular_component	trans-Golgi network
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030121	cellular_component	AP-1 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030136	cellular_component	clathrin-coated vesicle
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0032438	biological_process	melanosome organization
M	0032588	cellular_component	trans-Golgi network membrane
M	0035615	molecular_function	clathrin adaptor activity
M	0035646	biological_process	endosome to melanosome transport
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0051649	biological_process	establishment of localization in cell
M	0060155	biological_process	platelet dense granule organization
M	1903232	biological_process	melanosome assembly
S	0000139	cellular_component	Golgi membrane
S	0005515	molecular_function	protein binding
S	0005765	cellular_component	lysosomal membrane
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0005905	cellular_component	clathrin-coated pit
S	0006605	biological_process	protein targeting
S	0006886	biological_process	intracellular protein transport
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030121	cellular_component	AP-1 adaptor complex
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0032588	cellular_component	trans-Golgi network membrane
S	0035615	molecular_function	clathrin adaptor activity
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0060155	biological_process	platelet dense granule organization
S	1903232	biological_process	melanosome assembly
T	0005102	molecular_function	signaling receptor binding
T	0005515	molecular_function	protein binding
T	0005525	molecular_function	GTP binding
T	0005576	cellular_component	extracellular region
T	0016020	cellular_component	membrane
T	0017124	molecular_function	SH3 domain binding
T	0019049	biological_process	virus-mediated perturbation of host defense response
T	0019058	biological_process	viral life cycle
T	0019901	molecular_function	protein kinase binding
T	0020002	cellular_component	host cell plasma membrane
T	0031996	molecular_function	thioesterase binding
T	0033644	cellular_component	host cell membrane
T	0033668	biological_process	symbiont-mediated suppression of host apoptosis
T	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
T	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
T	0039521	biological_process	suppression by virus of host autophagy
T	0042288	molecular_function	MHC class I protein binding
T	0042609	molecular_function	CD4 receptor binding
T	0044177	cellular_component	host cell Golgi apparatus
T	0044178	cellular_component	host cell Golgi membrane
T	0044423	cellular_component	virion component
T	0045225	biological_process	negative regulation of CD4 production
T	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
T	0050848	biological_process	regulation of calcium-mediated signaling
T	0051117	molecular_function	ATPase binding
T	0070206	biological_process	protein trimerization
T	0075528	biological_process	perturbation by virus of host immune response

PDBデータベースに由来する情報

site_id	AC1
残基数	16
詳細	binding site for residue GTP C 1001

鎖名	残基
C	ASP26
C	GLY69
C	GLY70
C	LYS127
C	ASP129
C	CYS159
C	ALA160
C	MG1002
C	ALA27
C	ALA28
C	GLY29
C	LYS30
C	THR31
C	THR32
C	THR45
C	THR48

---

site_id	AC2
残基数	3
詳細	binding site for residue MG C 1002

鎖名	残基
C	THR31
C	THR48
C	GTP1001

---

site_id	AC3
残基数	18
詳細	binding site for residue GTP H 1001

鎖名	残基
H	ALA27
H	ALA28
H	GLY29
H	LYS30
H	THR31
H	THR32
H	THR45
H	ILE46
H	PRO47
H	THR48
H	LEU71
H	ASN126
H	LYS127
H	ASP129
H	CYS159
H	ALA160
H	THR161
H	MG1002

---

site_id	AC4
残基数	3
詳細	binding site for residue MG H 1002

鎖名	残基
H	THR31
H	THR48
H	GTP1001

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00989
残基数	11
詳細	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LVYKryasLYF

鎖名	残基	詳細
S	LEU57-PHE67

---

site_id	PS00990
残基数	21
詳細	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE

鎖名	残基	詳細
M	VAL157-GLU177

---

site_id	PS00991
残基数	15
詳細	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY

鎖名	残基	詳細
M	ILE253-TYR267

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:Q9BXS5

鎖名	残基	詳細
L	LYS47
H	GLY24
M	SER2

---

site_id	SWS_FT_FI2
残基数	2
詳細	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079

鎖名	残基	詳細
M	THR152
M	THR154

---

site_id	SWS_FT_FI3
残基数	1
詳細	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q32Q06

鎖名	残基	詳細
M	THR223
H	ALA160

---