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6C06

Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006351biological_processDNA-templated transcription
A0009274cellular_componentpeptidoglycan-based cell wall
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034062molecular_function5'-3' RNA polymerase activity
A0046983molecular_functionprotein dimerization activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006351biological_processDNA-templated transcription
B0009274cellular_componentpeptidoglycan-based cell wall
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0034062molecular_function5'-3' RNA polymerase activity
B0046983molecular_functionprotein dimerization activity
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
C0005515molecular_functionprotein binding
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006351biological_processDNA-templated transcription
C0009274cellular_componentpeptidoglycan-based cell wall
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0032549molecular_functionribonucleoside binding
C0034062molecular_function5'-3' RNA polymerase activity
C0046677biological_processresponse to antibiotic
D0000287molecular_functionmagnesium ion binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006351biological_processDNA-templated transcription
D0008270molecular_functionzinc ion binding
D0009274cellular_componentpeptidoglycan-based cell wall
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0034062molecular_function5'-3' RNA polymerase activity
D0046872molecular_functionmetal ion binding
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
E0005829cellular_componentcytosol
E0006351biological_processDNA-templated transcription
E0009274cellular_componentpeptidoglycan-based cell wall
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
F0003677molecular_functionDNA binding
F0003700molecular_functionDNA-binding transcription factor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0006352biological_processDNA-templated transcription initiation
F0006355biological_processregulation of DNA-templated transcription
F0009274cellular_componentpeptidoglycan-based cell wall
F0009415biological_processresponse to water
F0010468biological_processregulation of gene expression
F0016987molecular_functionsigma factor activity
F2000142biological_processregulation of DNA-templated transcription initiation
J0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
J0001108molecular_functionbacterial-type RNA polymerase holo enzyme binding
J0003676molecular_functionnucleic acid binding
J0005515molecular_functionprotein binding
J0009274cellular_componentpeptidoglycan-based cell wall
J0045893biological_processpositive regulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN D 1401
ChainResidue
DCYS891
DCYS968
DTHR970
DVAL974
DCYS975
DCYS978

site_idAC2
Number of Residues6
Detailsbinding site for residue ZN D 1402
ChainResidue
DGLY63
DLYS64
DCYS78
DCYS60
DTYR61
DCYS62

site_idAC3
Number of Residues3
Detailsbinding site for residue MG D 1403
ChainResidue
DASP535
DASP537
DASP539

site_idAC4
Number of Residues11
Detailsbinding site for residue FI8 D 1404
ChainResidue
CMET1051
CILE1052
CTHR1053
CGLN1054
CASP1094
CTHR1096
CGLU1119
CSER1120
DARG84
DLYS86
DARG412

Functional Information from PROSITE/UniProt
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV
ChainResidueDetails
CGLY882-VAL894

site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV
ChainResidueDetails
FASP319-VAL332

site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TldEIGqvygVTrerIrQIEsktMskL
ChainResidueDetails
FTHR488-LEU514

site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL
ChainResidueDetails
FLEU295-LEU302

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19
DetailsDNA_BIND: H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963
ChainResidueDetails
FLEU489-SER508
DCYS975
DCYS978
DCYS62
DCYS75
DCYS78
DASP535
DASP537
DASP539
DCYS891
DCYS968

218853

數據於2024-04-24公開中

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