6BPR

Crystal structure of cysteine, nitric oxide-bound ferrous form of the uncrosslinked F2-Tyr157 human cysteine dioxygenase

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000097	biological_process	sulfur amino acid biosynthetic process
A	0005506	molecular_function	iron ion binding
A	0005829	cellular_component	cytosol
A	0006534	biological_process	cysteine metabolic process
A	0006954	biological_process	inflammatory response
A	0007595	biological_process	lactation
A	0008198	molecular_function	ferrous iron binding
A	0008270	molecular_function	zinc ion binding
A	0010243	biological_process	response to organonitrogen compound
A	0016151	molecular_function	nickel cation binding
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0017172	molecular_function	cysteine dioxygenase activity
A	0019448	biological_process	L-cysteine catabolic process
A	0033762	biological_process	response to glucagon
A	0042412	biological_process	taurine biosynthetic process
A	0043200	biological_process	response to amino acid
A	0045471	biological_process	response to ethanol
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051384	biological_process	response to glucocorticoid
A	0051591	biological_process	response to cAMP

PDBデータベースに由来する情報

site_id	AC1
残基数	5
詳細	binding site for residue FE A 301

鎖名	残基
A	HIS86
A	HIS88
A	HIS140
A	CYS302
A	NO303

---

site_id	AC2
残基数	10
詳細	binding site for residue CYS A 302

鎖名	残基
A	HIS88
A	HIS140
A	F2Y157
A	MET179
A	FE301
A	NO303
A	TYR58
A	ARG60
A	LEU75
A	HIS86

---

site_id	AC3
残基数	7
詳細	binding site for residue NO A 303

鎖名	残基
A	HIS88
A	CYS93
A	HIS140
A	HIS155
A	F2Y157
A	FE301
A	CYS302

---

site_id	AC4
残基数	6
詳細	binding site for residue SO4 A 304

鎖名	残基
A	GLN34
A	ARG123
A	ALA131
A	TYR132
A	HOH408
A	HOH431

---

site_id	AC5
残基数	4
詳細	binding site for residue SO4 A 305

鎖名	残基
A	LYS119
A	ARG141
A	GLN169
A	HOH435

---

site_id	AC6
残基数	4
詳細	binding site for residue SO4 A 306

鎖名	残基
A	TYR56
A	HIS173
A	LYS174
A	HOH433

---

site_id	AC7
残基数	4
詳細	binding site for residue GOL A 307

鎖名	残基
A	ALA166
A	ASP168
A	HIS173
A	ASN175

---

site_id	AC8
残基数	4
詳細	binding site for residue GOL A 308

鎖名	残基
A	TYR58
A	SER83
A	SER84
A	CYS164

---

site_id	AC9
残基数	4
詳細	binding site for residue GOL A 309

鎖名	残基
A	HIS165
A	LYS174
A	HOH456
A	HOH490

---

site_id	AD1
残基数	6
詳細	binding site for residue GOL A 310

鎖名	残基
A	SER42
A	PRO44
A	LEU98
A	GLU127
A	HOH453
A	HOH484

---

site_id	AD2
残基数	8
詳細	binding site for residue GOL A 311

鎖名	残基
A	ASN101
A	GLU116
A	MET117
A	VAL118
A	ARG126
A	GLU127
A	HOH514
A	HOH534

---

site_id	AD3
残基数	4
詳細	binding site for residue GOL A 312

鎖名	残基
A	THR180
A	PHE181
A	LYS184
A	HOH424

---

site_id	AD4
残基数	3
詳細	binding site for residue GOL A 313

鎖名	残基
A	LYS8
A	ARG10
A	HOH442

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	3
詳細	BINDING: BINDING => ECO:0000269|PubMed:17135237

鎖名	残基	詳細
A	HIS86
A	HIS88
A	HIS140

---

site_id	SWS_FT_FI2
残基数	2
詳細	CROSSLNK: 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) => ECO:0000269|PubMed:17135237

鎖名	残基	詳細
A	CYS93
A	F2Y157

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