6BD4

Crystal structure of human apo-Frizzled4 receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005506	molecular_function	iron ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0042813	molecular_function	Wnt receptor activity
A	0043448	biological_process	alkane catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1101

Chain	Residue
A	CYS1006
A	CYS1009
A	CYS1039
A	CYS1042

---

site_id	AC2
Number of Residues	6
Details	binding site for residue OLC A 1102

Chain	Residue
A	TRP494
A	PHE440
A	LEU443
A	TYR444
A	LEU486
A	THR490

---

site_id	AC3
Number of Residues	6
Details	binding site for residue OLC A 1103

Chain	Residue
A	SER214
A	PHE218
A	TRP222
A	ASP471
A	MET474
A	PHE482

---

site_id	AC4
Number of Residues	7
Details	binding site for residue OLC A 1104

Chain	Residue
A	TYR250
A	ARG253
A	SER344
A	SER345
A	HIS348
A	TRP352
A	OLA1110

---

site_id	AC5
Number of Residues	4
Details	binding site for residue OLC A 1105

Chain	Residue
A	VAL275
A	ASN299
A	THR300
A	GLY301

---

site_id	AC6
Number of Residues	5
Details	binding site for residue OLA A 1106

Chain	Residue
A	VAL321
A	HIS343
A	PHE347
A	TYR398
A	ILE401

---

site_id	AC7
Number of Residues	4
Details	binding site for residue OLA A 1107

Chain	Residue
A	HIS343
A	TYR346
A	ILE349
A	ALA350

---

site_id	AC8
Number of Residues	7
Details	binding site for residue OLA A 1108

Chain	Residue
A	VAL392
A	PHE396
A	LEU399
A	THR403
A	ALA407
A	THR445
A	THR449

---

site_id	AC9
Number of Residues	3
Details	binding site for residue OLA A 1109

Chain	Residue
A	PHE231
A	ASN263
A	SO41113

---

site_id	AD1
Number of Residues	4
Details	binding site for residue OLA A 1110

Chain	Residue
A	THR300
A	LEU307
A	ILE364
A	OLC1104

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 A 1111

Chain	Residue
A	LEU384
A	PHE414
A	HOH1207
A	HOH1208

---

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 A 1112

Chain	Residue
A	GLN382
A	ASN383
A	LEU384
A	ARG417
A	TRP462
A	ARG466

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 A 1113

Chain	Residue
A	LEU242
A	SER345
A	TYR346
A	OLA1109

---

Functional Information from PROSITE/UniProt

site_id	PS00202
Number of Residues	11
Details	RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG

Chain	Residue	Details
A	ILE1033-GLY1043

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	ARG213-ILE243

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	ASP244-SER249
A	LYS334-GLY336

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	TYR250-VAL275

---

site_id	SWS_FT_FI4
Number of Residues	52
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	GLY276-ASN299
A	ARG366-ASN383
A	ASN461-ASN473

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	THR300-LEU333

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	HIS337-MET365

---

site_id	SWS_FT_FI7
Number of Residues	34
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	LEU384-SER418

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	ARG432-SER460

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30135577

Chain	Residue	Details
A	MET474-ILE495

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292

Chain	Residue	Details
A	CYS1006
A	CYS1009
A	CYS1039
A	CYS1042

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: N-formylmethionine => ECO:0000269|PubMed:1637309

Chain	Residue	Details
A	MET1001

---