6B6E

Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 500ms

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0008800	molecular_function	beta-lactamase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0033250	molecular_function	penicillinase activity
A	0033251	molecular_function	cephalosporinase activity
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue FZS A 301

Chain	Residue
A	CYS69
A	THR239
A	GLY240
A	9F2302
A	HOH437
A	HOH444
A	HOH450
A	SER70
A	ILE103
A	SER128
A	PRO169
A	ASN172
A	LYS236
A	THR237
A	GLY238

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site_id	AC2
Number of Residues	20
Details	binding site for residue 9F2 A 302

Chain	Residue
A	SER70
A	ILE103
A	SER128
A	PRO169
A	ASN172
A	ARG173
A	ARG222
A	LYS236
A	THR237
A	GLY238
A	THR239
A	GLY240
A	ASP241
A	FZS301
A	HOH437
A	HOH444
A	HOH461
A	HOH499
A	HOH526
A	HOH533

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Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL

Chain	Residue	Details
A	PHE66-LEU81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112

Chain	Residue	Details
A	SER70

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112

Chain	Residue	Details
A	GLU168

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112

Chain	Residue	Details
A	SER128
A	THR237

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112

Chain	Residue	Details
A	LYS73

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821

Chain	Residue	Details
A	ILE103

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