6AEJ
Crystal structure of human FTO in complex with small-molecule inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006307 | biological_process | DNA alkylation repair |
| A | 0035515 | molecular_function | oxidative RNA demethylase activity |
| A | 0035516 | molecular_function | broad specificity oxidative DNA demethylase activity |
| A | 0035552 | biological_process | obsolete oxidative single-stranded DNA demethylation |
| A | 0035553 | biological_process | obsolete oxidative single-stranded RNA demethylation |
| A | 0040014 | biological_process | regulation of multicellular organism growth |
| A | 0042245 | biological_process | RNA repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 7YC A 601 |
| Chain | Residue |
| A | ARG96 |
| A | TYR295 |
| A | HIS307 |
| A | VAL309 |
| A | ARG316 |
| A | SER318 |
| A | THR320 |
| A | ARG322 |
| A | ZN602 |
| A | TYR106 |
| A | TYR108 |
| A | ASN205 |
| A | VAL228 |
| A | HIS231 |
| A | HIS232 |
| A | ASP233 |
| A | GLU234 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 602 |
| Chain | Residue |
| A | HIS231 |
| A | ASP233 |
| A | HIS307 |
| A | 7YC601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0007744|PDB:3LFM |
| Chain | Residue | Details |
| A | ARG96 | |
| A | TYR108 | |
| A | THR320 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN |
| Chain | Residue | Details |
| A | ASN205 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 |
| Chain | Residue | Details |
| A | HIS231 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 |
| Chain | Residue | Details |
| A | ASP233 | |
| A | HIS307 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 |
| Chain | Residue | Details |
| A | TYR295 | |
| A | ARG316 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2 |
| Chain | Residue | Details |
| A | ARG322 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS216 |
