5ZQF

Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MN A 1301

Chain	Residue
A	ASP557
A	ASP559

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site_id	AC2
Number of Residues	1
Details	binding site for residue MN A 1302

Chain	Residue
A	ASN867

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Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS

Chain	Residue	Details
A	LEU475-SER483

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401

Chain	Residue	Details
A	TYR821

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995

Chain	Residue	Details
A	GLU477

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401

Chain	Residue	Details
A	ASP557
A	ASP559

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Interaction with DNA

Chain	Residue	Details
A	LYS505
A	ASN508
A	ARG677
A	LYS678
A	LYS739
A	TRP947

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995

Chain	Residue	Details
A	TYR773

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ARG820

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site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Important for DNA bending; intercalates between base pairs of target DNA

Chain	Residue	Details
A	ILE872

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site_id	SWS_FT_FI8
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS595
A	LYS630
A	LYS641
A	LYS671
A	LYS707
A	LYS1087

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS600
A	LYS638

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