5ZNI
Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | GLY23 |
| A | HOH427 |
| A | ARG27 |
| A | ARG45 |
| A | ARG88 |
| A | GLY90 |
| A | SER91 |
| A | YMZ302 |
| A | HOH409 |
| A | HOH410 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue YMZ A 302 |
| Chain | Residue |
| A | HIS7 |
| A | ARG45 |
| A | CYS92 |
| A | GLY93 |
| A | TYR160 |
| A | VAL181 |
| A | GLU182 |
| A | MET183 |
| A | ASP206 |
| A | GLY207 |
| A | CYS208 |
| A | PRO209 |
| A | PO4301 |
| A | HOH401 |
| A | HOH442 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8I3X4 |
| Chain | Residue | Details |
| A | ASP206 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8I3X4 |
| Chain | Residue | Details |
| A | ARG45 | |
| A | HIS7 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:30602534, ECO:0007744|PDB:5ZNI |
| Chain | Residue | Details |
| A | GLY23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:30602534, ECO:0007744|PDB:5ZNC, ECO:0007744|PDB:5ZNI |
| Chain | Residue | Details |
| A | ARG88 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:Q8I3X4 |
| Chain | Residue | Details |
| A | MET183 |
