5ZKQ
Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003796 | molecular_function | lysozyme activity |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004992 | molecular_function | platelet activating factor receptor activity |
A | 0006935 | biological_process | chemotaxis |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0009253 | biological_process | peptidoglycan catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016998 | biological_process | cell wall macromolecule catabolic process |
B | 0003796 | molecular_function | lysozyme activity |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0004992 | molecular_function | platelet activating factor receptor activity |
B | 0006935 | biological_process | chemotaxis |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0009253 | biological_process | peptidoglycan catabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016998 | biological_process | cell wall macromolecule catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue 9EU A 501 |
Chain | Residue |
A | TYR22 |
A | HIS188 |
A | ILE191 |
A | GLN252 |
A | LEU279 |
A | OLC502 |
A | TRP73 |
A | TYR77 |
A | GLY94 |
A | PHE97 |
A | CYS173 |
A | PHE174 |
A | GLU175 |
A | TYR177 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue OLC A 502 |
Chain | Residue |
A | TYR151 |
A | PHE152 |
A | GLU178 |
A | PRO183 |
A | PHE190 |
A | 9EU501 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue OLC A 503 |
Chain | Residue |
A | TYR151 |
A | LEU155 |
A | ASP156 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue OLC A 504 |
Chain | Residue |
A | TYR102 |
A | VAL143 |
A | ALA144 |
A | ILE145 |
A | SER194 |
site_id | AC5 |
Number of Residues | 1 |
Details | binding site for residue OLC A 505 |
Chain | Residue |
A | LEU153 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue ZN A 506 |
Chain | Residue |
A | HIS4 |
A | HIS8 |
A | GLU259 |
A | HIS268 |
A | ASN272 |
site_id | AC7 |
Number of Residues | 16 |
Details | binding site for residue 9EU B 1201 |
Chain | Residue |
B | TYR22 |
B | TRP73 |
B | TYR77 |
B | GLY94 |
B | PHE97 |
B | PHE98 |
B | PHE152 |
B | CYS173 |
B | PHE174 |
B | GLU175 |
B | TYR177 |
B | HIS188 |
B | ILE191 |
B | HIS248 |
B | GLN252 |
B | OLC1202 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue OLC B 1202 |
Chain | Residue |
B | SER181 |
B | PRO183 |
B | VAL184 |
B | 9EU1201 |
B | OLC1203 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue OLC B 1203 |
Chain | Residue |
B | TYR151 |
B | OLC1202 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue OLC B 1204 |
Chain | Residue |
B | ASN58 |
B | MET61 |
B | ARG131 |
B | ILE135 |
B | LEU139 |
B | TRP142 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1205 |
Chain | Residue |
B | HIS8 |
B | GLU259 |
B | HIS268 |
B | ASN272 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 1206 |
Chain | Residue |
B | MET1062 |
B | SO41211 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 1207 |
Chain | Residue |
B | GLY166 |
B | ARG1032 |
B | ARG1036 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 1208 |
Chain | Residue |
B | ARG1075 |
B | ARG1081 |
site_id | AD6 |
Number of Residues | 1 |
Details | binding site for residue SO4 B 1209 |
Chain | Residue |
B | GLY1069 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 1210 |
Chain | Residue |
B | THR1098 |
B | PRO1099 |
B | ASN1100 |
B | ARG1101 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 1211 |
Chain | Residue |
B | GLY1066 |
B | SO41206 |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CSVaFLGVITYNRYQaV |
Chain | Residue | Details |
A | CYS103-VAL119 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | LEU17-TRP38 | |
B | LEU17-TRP38 |
site_id | SWS_FT_FI2 |
Number of Residues | 68 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | VAL39-ILE54 | |
A | ASN114-ARG133 | |
B | VAL39-ILE54 | |
B | ASN114-ARG133 |
site_id | SWS_FT_FI3 |
Number of Residues | 38 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | PHE55-ILE74 | |
B | PHE55-ILE74 |
site_id | SWS_FT_FI4 |
Number of Residues | 130 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | VAL75-ASN91 | |
A | ASP156-VAL184 | |
A | TRP255-GLN276 | |
B | VAL75-ASN91 | |
B | ASP156-VAL184 | |
B | TRP255-GLN276 |
site_id | SWS_FT_FI5 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | VAL92-TYR113 | |
B | VAL92-TYR113 |
site_id | SWS_FT_FI6 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | GLY134-LEU155 | |
B | GLY134-LEU155 |
site_id | SWS_FT_FI7 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
Chain | Residue | Details |
A | LEU185-CYS205 | |
B | LEU185-CYS205 |
site_id | SWS_FT_FI8 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
Chain | Residue | Details |
A | ALA234-PRO254 | |
B | ALA234-PRO254 |
site_id | SWS_FT_FI9 |
Number of Residues | 38 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
Chain | Residue | Details |
A | VAL277-LEU296 | |
B | VAL277-LEU296 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASP169 | |
B | ASP169 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | GLU1010 | |
B | GLU1010 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | PHE1060 | |
B | PHE1060 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
Chain | Residue | Details |
A | SER1073 | |
A | ASN1088 | |
B | SER1073 | |
B | ASN1088 |