5ZHX

Crystal structure of SmgGDS-558 and farnesylated RhoA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0043547	biological_process	positive regulation of GTPase activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0043547	biological_process	positive regulation of GTPase activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0043547	biological_process	positive regulation of GTPase activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0043547	biological_process	positive regulation of GTPase activity
e	0000166	molecular_function	nucleotide binding
e	0000902	biological_process	cell morphogenesis
e	0001764	biological_process	neuron migration
e	0001822	biological_process	kidney development
e	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
e	0002363	biological_process	alpha-beta T cell lineage commitment
e	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
e	0003189	biological_process	aortic valve formation
e	0003924	molecular_function	GTPase activity
e	0003925	molecular_function	G protein activity
e	0005515	molecular_function	protein binding
e	0005525	molecular_function	GTP binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005768	cellular_component	endosome
e	0005789	cellular_component	endoplasmic reticulum membrane
e	0005829	cellular_component	cytosol
e	0005856	cellular_component	cytoskeleton
e	0005886	cellular_component	plasma membrane
e	0005925	cellular_component	focal adhesion
e	0005938	cellular_component	cell cortex
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0007010	biological_process	cytoskeleton organization
e	0007049	biological_process	cell cycle
e	0007155	biological_process	cell adhesion
e	0007160	biological_process	cell-matrix adhesion
e	0007264	biological_process	small GTPase-mediated signal transduction
e	0007266	biological_process	Rho protein signal transduction
e	0007519	biological_process	skeletal muscle tissue development
e	0009898	cellular_component	cytoplasmic side of plasma membrane
e	0010812	biological_process	negative regulation of cell-substrate adhesion
e	0010975	biological_process	regulation of neuron projection development
e	0016020	cellular_component	membrane
e	0016477	biological_process	cell migration
e	0016787	molecular_function	hydrolase activity
e	0017022	molecular_function	myosin binding
e	0019901	molecular_function	protein kinase binding
e	0021762	biological_process	substantia nigra development
e	0021795	biological_process	cerebral cortex cell migration
e	0021861	biological_process	forebrain radial glial cell differentiation
e	0030027	cellular_component	lamellipodium
e	0030036	biological_process	actin cytoskeleton organization
e	0030054	cellular_component	cell junction
e	0030154	biological_process	cell differentiation
e	0030334	biological_process	regulation of cell migration
e	0030425	cellular_component	dendrite
e	0030496	cellular_component	midbody
e	0030521	biological_process	androgen receptor signaling pathway
e	0030667	cellular_component	secretory granule membrane
e	0031122	biological_process	cytoplasmic microtubule organization
e	0031982	cellular_component	vesicle
e	0032154	cellular_component	cleavage furrow
e	0032467	biological_process	positive regulation of cytokinesis
e	0032587	cellular_component	ruffle membrane
e	0032956	biological_process	regulation of actin cytoskeleton organization
e	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
e	0033688	biological_process	regulation of osteoblast proliferation
e	0034329	biological_process	cell junction assembly
e	0034446	biological_process	substrate adhesion-dependent cell spreading
e	0035385	biological_process	Roundabout signaling pathway
e	0036089	biological_process	cleavage furrow formation
e	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
e	0042476	biological_process	odontogenesis
e	0042995	cellular_component	cell projection
e	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
e	0043149	biological_process	stress fiber assembly
e	0043197	cellular_component	dendritic spine
e	0043296	cellular_component	apical junction complex
e	0043297	biological_process	apical junction assembly
e	0043366	biological_process	beta selection
e	0043542	biological_process	endothelial cell migration
e	0043931	biological_process	ossification involved in bone maturation
e	0044319	biological_process	wound healing, spreading of cells
e	0045198	biological_process	establishment of epithelial cell apical/basal polarity
e	0045666	biological_process	positive regulation of neuron differentiation
e	0045792	biological_process	negative regulation of cell size
e	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
e	0050919	biological_process	negative chemotaxis
e	0051301	biological_process	cell division
e	0051496	biological_process	positive regulation of stress fiber assembly
e	0051893	biological_process	regulation of focal adhesion assembly
e	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
e	0060193	biological_process	positive regulation of lipase activity
e	0061430	biological_process	bone trabecula morphogenesis
e	0070062	cellular_component	extracellular exosome
e	0070507	biological_process	regulation of microtubule cytoskeleton organization
e	0071222	biological_process	cellular response to lipopolysaccharide
e	0071345	biological_process	cellular response to cytokine stimulus
e	0071526	biological_process	semaphorin-plexin signaling pathway
e	0071803	biological_process	positive regulation of podosome assembly
e	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
e	0071944	cellular_component	cell periphery
e	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
e	0090307	biological_process	mitotic spindle assembly
e	0090324	biological_process	negative regulation of oxidative phosphorylation
e	0097049	biological_process	motor neuron apoptotic process
e	0097498	biological_process	endothelial tube lumen extension
e	0098794	cellular_component	postsynapse
e	0098978	cellular_component	glutamatergic synapse
e	0099159	biological_process	regulation of modification of postsynaptic structure
e	0101003	cellular_component	ficolin-1-rich granule membrane
e	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
e	1902766	biological_process	skeletal muscle satellite cell migration
e	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
e	1903673	biological_process	mitotic cleavage furrow formation
e	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
e	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
e	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
e	1990869	biological_process	cellular response to chemokine
e	2000177	biological_process	regulation of neural precursor cell proliferation
e	2000406	biological_process	positive regulation of T cell migration
e	2000672	biological_process	negative regulation of motor neuron apoptotic process
f	0000166	molecular_function	nucleotide binding
f	0000902	biological_process	cell morphogenesis
f	0001764	biological_process	neuron migration
f	0001822	biological_process	kidney development
f	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
f	0002363	biological_process	alpha-beta T cell lineage commitment
f	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
f	0003189	biological_process	aortic valve formation
f	0003924	molecular_function	GTPase activity
f	0003925	molecular_function	G protein activity
f	0005515	molecular_function	protein binding
f	0005525	molecular_function	GTP binding
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005768	cellular_component	endosome
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005886	cellular_component	plasma membrane
f	0005925	cellular_component	focal adhesion
f	0005938	cellular_component	cell cortex
f	0006357	biological_process	regulation of transcription by RNA polymerase II
f	0007010	biological_process	cytoskeleton organization
f	0007049	biological_process	cell cycle
f	0007155	biological_process	cell adhesion
f	0007160	biological_process	cell-matrix adhesion
f	0007264	biological_process	small GTPase-mediated signal transduction
f	0007266	biological_process	Rho protein signal transduction
f	0007519	biological_process	skeletal muscle tissue development
f	0009898	cellular_component	cytoplasmic side of plasma membrane
f	0010812	biological_process	negative regulation of cell-substrate adhesion
f	0010975	biological_process	regulation of neuron projection development
f	0016020	cellular_component	membrane
f	0016477	biological_process	cell migration
f	0016787	molecular_function	hydrolase activity
f	0017022	molecular_function	myosin binding
f	0019901	molecular_function	protein kinase binding
f	0021762	biological_process	substantia nigra development
f	0021795	biological_process	cerebral cortex cell migration
f	0021861	biological_process	forebrain radial glial cell differentiation
f	0030027	cellular_component	lamellipodium
f	0030036	biological_process	actin cytoskeleton organization
f	0030054	cellular_component	cell junction
f	0030154	biological_process	cell differentiation
f	0030334	biological_process	regulation of cell migration
f	0030425	cellular_component	dendrite
f	0030496	cellular_component	midbody
f	0030521	biological_process	androgen receptor signaling pathway
f	0030667	cellular_component	secretory granule membrane
f	0031122	biological_process	cytoplasmic microtubule organization
f	0031982	cellular_component	vesicle
f	0032154	cellular_component	cleavage furrow
f	0032467	biological_process	positive regulation of cytokinesis
f	0032587	cellular_component	ruffle membrane
f	0032956	biological_process	regulation of actin cytoskeleton organization
f	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
f	0033688	biological_process	regulation of osteoblast proliferation
f	0034329	biological_process	cell junction assembly
f	0034446	biological_process	substrate adhesion-dependent cell spreading
f	0035385	biological_process	Roundabout signaling pathway
f	0036089	biological_process	cleavage furrow formation
f	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
f	0042476	biological_process	odontogenesis
f	0042995	cellular_component	cell projection
f	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
f	0043149	biological_process	stress fiber assembly
f	0043197	cellular_component	dendritic spine
f	0043296	cellular_component	apical junction complex
f	0043297	biological_process	apical junction assembly
f	0043366	biological_process	beta selection
f	0043542	biological_process	endothelial cell migration
f	0043931	biological_process	ossification involved in bone maturation
f	0044319	biological_process	wound healing, spreading of cells
f	0045198	biological_process	establishment of epithelial cell apical/basal polarity
f	0045666	biological_process	positive regulation of neuron differentiation
f	0045792	biological_process	negative regulation of cell size
f	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
f	0050919	biological_process	negative chemotaxis
f	0051301	biological_process	cell division
f	0051496	biological_process	positive regulation of stress fiber assembly
f	0051893	biological_process	regulation of focal adhesion assembly
f	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
f	0060193	biological_process	positive regulation of lipase activity
f	0061430	biological_process	bone trabecula morphogenesis
f	0070062	cellular_component	extracellular exosome
f	0070507	biological_process	regulation of microtubule cytoskeleton organization
f	0071222	biological_process	cellular response to lipopolysaccharide
f	0071345	biological_process	cellular response to cytokine stimulus
f	0071526	biological_process	semaphorin-plexin signaling pathway
f	0071803	biological_process	positive regulation of podosome assembly
f	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
f	0071944	cellular_component	cell periphery
f	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
f	0090307	biological_process	mitotic spindle assembly
f	0090324	biological_process	negative regulation of oxidative phosphorylation
f	0097049	biological_process	motor neuron apoptotic process
f	0097498	biological_process	endothelial tube lumen extension
f	0098794	cellular_component	postsynapse
f	0098978	cellular_component	glutamatergic synapse
f	0099159	biological_process	regulation of modification of postsynaptic structure
f	0101003	cellular_component	ficolin-1-rich granule membrane
f	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
f	1902766	biological_process	skeletal muscle satellite cell migration
f	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
f	1903673	biological_process	mitotic cleavage furrow formation
f	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
f	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
f	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
f	1990869	biological_process	cellular response to chemokine
f	2000177	biological_process	regulation of neural precursor cell proliferation
f	2000406	biological_process	positive regulation of T cell migration
f	2000672	biological_process	negative regulation of motor neuron apoptotic process
g	0000166	molecular_function	nucleotide binding
g	0000902	biological_process	cell morphogenesis
g	0001764	biological_process	neuron migration
g	0001822	biological_process	kidney development
g	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
g	0002363	biological_process	alpha-beta T cell lineage commitment
g	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
g	0003189	biological_process	aortic valve formation
g	0003924	molecular_function	GTPase activity
g	0003925	molecular_function	G protein activity
g	0005515	molecular_function	protein binding
g	0005525	molecular_function	GTP binding
g	0005634	cellular_component	nucleus
g	0005737	cellular_component	cytoplasm
g	0005768	cellular_component	endosome
g	0005789	cellular_component	endoplasmic reticulum membrane
g	0005829	cellular_component	cytosol
g	0005856	cellular_component	cytoskeleton
g	0005886	cellular_component	plasma membrane
g	0005925	cellular_component	focal adhesion
g	0005938	cellular_component	cell cortex
g	0006357	biological_process	regulation of transcription by RNA polymerase II
g	0007010	biological_process	cytoskeleton organization
g	0007049	biological_process	cell cycle
g	0007155	biological_process	cell adhesion
g	0007160	biological_process	cell-matrix adhesion
g	0007264	biological_process	small GTPase-mediated signal transduction
g	0007266	biological_process	Rho protein signal transduction
g	0007519	biological_process	skeletal muscle tissue development
g	0009898	cellular_component	cytoplasmic side of plasma membrane
g	0010812	biological_process	negative regulation of cell-substrate adhesion
g	0010975	biological_process	regulation of neuron projection development
g	0016020	cellular_component	membrane
g	0016477	biological_process	cell migration
g	0016787	molecular_function	hydrolase activity
g	0017022	molecular_function	myosin binding
g	0019901	molecular_function	protein kinase binding
g	0021762	biological_process	substantia nigra development
g	0021795	biological_process	cerebral cortex cell migration
g	0021861	biological_process	forebrain radial glial cell differentiation
g	0030027	cellular_component	lamellipodium
g	0030036	biological_process	actin cytoskeleton organization
g	0030054	cellular_component	cell junction
g	0030154	biological_process	cell differentiation
g	0030334	biological_process	regulation of cell migration
g	0030425	cellular_component	dendrite
g	0030496	cellular_component	midbody
g	0030521	biological_process	androgen receptor signaling pathway
g	0030667	cellular_component	secretory granule membrane
g	0031122	biological_process	cytoplasmic microtubule organization
g	0031982	cellular_component	vesicle
g	0032154	cellular_component	cleavage furrow
g	0032467	biological_process	positive regulation of cytokinesis
g	0032587	cellular_component	ruffle membrane
g	0032956	biological_process	regulation of actin cytoskeleton organization
g	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
g	0033688	biological_process	regulation of osteoblast proliferation
g	0034329	biological_process	cell junction assembly
g	0034446	biological_process	substrate adhesion-dependent cell spreading
g	0035385	biological_process	Roundabout signaling pathway
g	0036089	biological_process	cleavage furrow formation
g	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
g	0042476	biological_process	odontogenesis
g	0042995	cellular_component	cell projection
g	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
g	0043149	biological_process	stress fiber assembly
g	0043197	cellular_component	dendritic spine
g	0043296	cellular_component	apical junction complex
g	0043297	biological_process	apical junction assembly
g	0043366	biological_process	beta selection
g	0043542	biological_process	endothelial cell migration
g	0043931	biological_process	ossification involved in bone maturation
g	0044319	biological_process	wound healing, spreading of cells
g	0045198	biological_process	establishment of epithelial cell apical/basal polarity
g	0045666	biological_process	positive regulation of neuron differentiation
g	0045792	biological_process	negative regulation of cell size
g	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
g	0050919	biological_process	negative chemotaxis
g	0051301	biological_process	cell division
g	0051496	biological_process	positive regulation of stress fiber assembly
g	0051893	biological_process	regulation of focal adhesion assembly
g	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
g	0060193	biological_process	positive regulation of lipase activity
g	0061430	biological_process	bone trabecula morphogenesis
g	0070062	cellular_component	extracellular exosome
g	0070507	biological_process	regulation of microtubule cytoskeleton organization
g	0071222	biological_process	cellular response to lipopolysaccharide
g	0071345	biological_process	cellular response to cytokine stimulus
g	0071526	biological_process	semaphorin-plexin signaling pathway
g	0071803	biological_process	positive regulation of podosome assembly
g	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
g	0071944	cellular_component	cell periphery
g	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
g	0090307	biological_process	mitotic spindle assembly
g	0090324	biological_process	negative regulation of oxidative phosphorylation
g	0097049	biological_process	motor neuron apoptotic process
g	0097498	biological_process	endothelial tube lumen extension
g	0098794	cellular_component	postsynapse
g	0098978	cellular_component	glutamatergic synapse
g	0099159	biological_process	regulation of modification of postsynaptic structure
g	0101003	cellular_component	ficolin-1-rich granule membrane
g	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
g	1902766	biological_process	skeletal muscle satellite cell migration
g	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
g	1903673	biological_process	mitotic cleavage furrow formation
g	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
g	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
g	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
g	1990869	biological_process	cellular response to chemokine
g	2000177	biological_process	regulation of neural precursor cell proliferation
g	2000406	biological_process	positive regulation of T cell migration
g	2000672	biological_process	negative regulation of motor neuron apoptotic process
h	0000166	molecular_function	nucleotide binding
h	0000902	biological_process	cell morphogenesis
h	0001764	biological_process	neuron migration
h	0001822	biological_process	kidney development
h	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
h	0002363	biological_process	alpha-beta T cell lineage commitment
h	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
h	0003189	biological_process	aortic valve formation
h	0003924	molecular_function	GTPase activity
h	0003925	molecular_function	G protein activity
h	0005515	molecular_function	protein binding
h	0005525	molecular_function	GTP binding
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005768	cellular_component	endosome
h	0005789	cellular_component	endoplasmic reticulum membrane
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005886	cellular_component	plasma membrane
h	0005925	cellular_component	focal adhesion
h	0005938	cellular_component	cell cortex
h	0006357	biological_process	regulation of transcription by RNA polymerase II
h	0007010	biological_process	cytoskeleton organization
h	0007049	biological_process	cell cycle
h	0007155	biological_process	cell adhesion
h	0007160	biological_process	cell-matrix adhesion
h	0007264	biological_process	small GTPase-mediated signal transduction
h	0007266	biological_process	Rho protein signal transduction
h	0007519	biological_process	skeletal muscle tissue development
h	0009898	cellular_component	cytoplasmic side of plasma membrane
h	0010812	biological_process	negative regulation of cell-substrate adhesion
h	0010975	biological_process	regulation of neuron projection development
h	0016020	cellular_component	membrane
h	0016477	biological_process	cell migration
h	0016787	molecular_function	hydrolase activity
h	0017022	molecular_function	myosin binding
h	0019901	molecular_function	protein kinase binding
h	0021762	biological_process	substantia nigra development
h	0021795	biological_process	cerebral cortex cell migration
h	0021861	biological_process	forebrain radial glial cell differentiation
h	0030027	cellular_component	lamellipodium
h	0030036	biological_process	actin cytoskeleton organization
h	0030054	cellular_component	cell junction
h	0030154	biological_process	cell differentiation
h	0030334	biological_process	regulation of cell migration
h	0030425	cellular_component	dendrite
h	0030496	cellular_component	midbody
h	0030521	biological_process	androgen receptor signaling pathway
h	0030667	cellular_component	secretory granule membrane
h	0031122	biological_process	cytoplasmic microtubule organization
h	0031982	cellular_component	vesicle
h	0032154	cellular_component	cleavage furrow
h	0032467	biological_process	positive regulation of cytokinesis
h	0032587	cellular_component	ruffle membrane
h	0032956	biological_process	regulation of actin cytoskeleton organization
h	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
h	0033688	biological_process	regulation of osteoblast proliferation
h	0034329	biological_process	cell junction assembly
h	0034446	biological_process	substrate adhesion-dependent cell spreading
h	0035385	biological_process	Roundabout signaling pathway
h	0036089	biological_process	cleavage furrow formation
h	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
h	0042476	biological_process	odontogenesis
h	0042995	cellular_component	cell projection
h	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
h	0043149	biological_process	stress fiber assembly
h	0043197	cellular_component	dendritic spine
h	0043296	cellular_component	apical junction complex
h	0043297	biological_process	apical junction assembly
h	0043366	biological_process	beta selection
h	0043542	biological_process	endothelial cell migration
h	0043931	biological_process	ossification involved in bone maturation
h	0044319	biological_process	wound healing, spreading of cells
h	0045198	biological_process	establishment of epithelial cell apical/basal polarity
h	0045666	biological_process	positive regulation of neuron differentiation
h	0045792	biological_process	negative regulation of cell size
h	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
h	0050919	biological_process	negative chemotaxis
h	0051301	biological_process	cell division
h	0051496	biological_process	positive regulation of stress fiber assembly
h	0051893	biological_process	regulation of focal adhesion assembly
h	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
h	0060193	biological_process	positive regulation of lipase activity
h	0061430	biological_process	bone trabecula morphogenesis
h	0070062	cellular_component	extracellular exosome
h	0070507	biological_process	regulation of microtubule cytoskeleton organization
h	0071222	biological_process	cellular response to lipopolysaccharide
h	0071345	biological_process	cellular response to cytokine stimulus
h	0071526	biological_process	semaphorin-plexin signaling pathway
h	0071803	biological_process	positive regulation of podosome assembly
h	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
h	0071944	cellular_component	cell periphery
h	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
h	0090307	biological_process	mitotic spindle assembly
h	0090324	biological_process	negative regulation of oxidative phosphorylation
h	0097049	biological_process	motor neuron apoptotic process
h	0097498	biological_process	endothelial tube lumen extension
h	0098794	cellular_component	postsynapse
h	0098978	cellular_component	glutamatergic synapse
h	0099159	biological_process	regulation of modification of postsynaptic structure
h	0101003	cellular_component	ficolin-1-rich granule membrane
h	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
h	1902766	biological_process	skeletal muscle satellite cell migration
h	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
h	1903673	biological_process	mitotic cleavage furrow formation
h	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
h	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
h	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
h	1990869	biological_process	cellular response to chemokine
h	2000177	biological_process	regulation of neural precursor cell proliferation
h	2000406	biological_process	positive regulation of T cell migration
h	2000672	biological_process	negative regulation of motor neuron apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for Di-peptide FAR e 201 and CYS e 190

Chain	Residue
A	CYS117
A	TYR118
A	GLN124
A	LEU127
A	LEU136
A	MET152
e	LEU191

---

site_id	AC2
Number of Residues	9
Details	binding site for Di-peptide FAR f 201 and CYS f 190

Chain	Residue
B	LEU136
B	LEU139
B	MET152
B	CYS153
B	VAL155
f	GLY189
f	LEU191
B	TYR118
B	GLN124

---

site_id	AC3
Number of Residues	10
Details	binding site for Di-peptide FAR g 201 and CYS g 190

Chain	Residue
C	GLN124
C	LEU136
C	LEU139
C	LEU149
C	MET152
C	CYS153
C	VAL155
C	ASN159
g	GLY189
g	LEU191

---

site_id	AC4
Number of Residues	6
Details	binding site for Di-peptide FAR h 201 and CYS h 190

Chain	Residue
D	CYS117
D	TYR118
D	GLN124
D	MET152
D	ASN159
h	LEU191

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804

Chain	Residue	Details
e	GLY12
e	ASN117
f	GLY12
f	ASN117
g	GLY12
g	ASN117
h	GLY12
h	ASN117

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62820

Chain	Residue	Details
e	PHE30
h	PHE30
h	ASP59
h	SER160
e	ASP59
e	SER160
f	PHE30
f	ASP59
f	SER160
g	PHE30
g	ASP59
g	SER160

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863

Chain	Residue	Details
e	GLY189
f	GLY189
g	GLY189
h	GLY189

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538

Chain	Residue	Details
e	TYR34
f	TYR34
g	TYR34
h	TYR34

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103

Chain	Residue	Details
e	THR37
f	THR37
g	THR37
h	THR37

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215

Chain	Residue	Details
e	ASN41
f	ASN41
g	ASN41
h	ASN41

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0

Chain	Residue	Details
e	GLN63
f	GLN63
g	GLN63
h	GLN63

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591

Chain	Residue	Details
e	SER188
f	SER188
g	SER188
h	SER188

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585

Chain	Residue	Details
e	CYS190
f	CYS190
g	CYS190
h	CYS190

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	LIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757

Chain	Residue	Details
e	LYS185
h	LYS185
h	LYS186
h	LYS187
e	LYS186
e	LYS187
f	LYS185
f	LYS186
f	LYS187
g	LYS185
g	LYS186
g	LYS187

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585

Chain	Residue	Details
e	CYS190
f	CYS190
g	CYS190
h	CYS190

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704

Chain	Residue	Details
e	TYR34
f	TYR34
g	TYR34
h	TYR34

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059

Chain	Residue	Details
e	THR37
f	THR37
g	THR37
h	THR37

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831

Chain	Residue	Details
e	LYS135
f	LYS135
g	LYS135
h	LYS135

---