5TCZ

NMR solution structure of engineered Protoxin-II analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005246	molecular_function	calcium channel regulator activity
A	0005576	cellular_component	extracellular region
A	0008289	molecular_function	lipid binding
A	0017080	molecular_function	sodium channel regulator activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A => ECO:0000305|PubMed:30661758

Chain	Residue	Details
A	TRP7
A	GLN9

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Electrostatic gating-modifier of Nav1.7/SCN9A that antagonizes outward gating-charge movement through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2 => ECO:0000305|PubMed:30661758

Chain	Residue	Details
A	ARG24

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A; it also stabilizes the toxin for productive receptor site engagement => ECO:0000305|PubMed:30661758

Chain	Residue	Details
A	TRP26

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Antagonizes outward gating-charge movement of Nav1.7/SCN9A through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2 => ECO:0000305|PubMed:30661758

Chain	Residue	Details
A	LYS28

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