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5Q0C

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0008152biological_processmetabolic process
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030018cellular_componentZ disc
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0008152biological_processmetabolic process
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030018cellular_componentZ disc
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005975biological_processcarbohydrate metabolic process
C0005986biological_processsucrose biosynthetic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0008152biological_processmetabolic process
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030018cellular_componentZ disc
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0070161cellular_componentanchoring junction
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005975biological_processcarbohydrate metabolic process
D0005986biological_processsucrose biosynthetic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0008152biological_processmetabolic process
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030018cellular_componentZ disc
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
E0003824molecular_functioncatalytic activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005975biological_processcarbohydrate metabolic process
E0005986biological_processsucrose biosynthetic process
E0006000biological_processfructose metabolic process
E0006002biological_processfructose 6-phosphate metabolic process
E0006094biological_processgluconeogenesis
E0008152biological_processmetabolic process
E0016787molecular_functionhydrolase activity
E0016791molecular_functionphosphatase activity
E0030018cellular_componentZ disc
E0030388biological_processfructose 1,6-bisphosphate metabolic process
E0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
E0042578molecular_functionphosphoric ester hydrolase activity
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0070062cellular_componentextracellular exosome
E0070161cellular_componentanchoring junction
F0003824molecular_functioncatalytic activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005975biological_processcarbohydrate metabolic process
F0005986biological_processsucrose biosynthetic process
F0006000biological_processfructose metabolic process
F0006002biological_processfructose 6-phosphate metabolic process
F0006094biological_processgluconeogenesis
F0008152biological_processmetabolic process
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030018cellular_componentZ disc
F0030388biological_processfructose 1,6-bisphosphate metabolic process
F0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
F0042578molecular_functionphosphoric ester hydrolase activity
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0070161cellular_componentanchoring junction
G0003824molecular_functioncatalytic activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005975biological_processcarbohydrate metabolic process
G0005986biological_processsucrose biosynthetic process
G0006000biological_processfructose metabolic process
G0006002biological_processfructose 6-phosphate metabolic process
G0006094biological_processgluconeogenesis
G0008152biological_processmetabolic process
G0016787molecular_functionhydrolase activity
G0016791molecular_functionphosphatase activity
G0030018cellular_componentZ disc
G0030388biological_processfructose 1,6-bisphosphate metabolic process
G0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
G0042578molecular_functionphosphoric ester hydrolase activity
G0042802molecular_functionidentical protein binding
G0046872molecular_functionmetal ion binding
G0070062cellular_componentextracellular exosome
G0070161cellular_componentanchoring junction
H0003824molecular_functioncatalytic activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005975biological_processcarbohydrate metabolic process
H0005986biological_processsucrose biosynthetic process
H0006000biological_processfructose metabolic process
H0006002biological_processfructose 6-phosphate metabolic process
H0006094biological_processgluconeogenesis
H0008152biological_processmetabolic process
H0016787molecular_functionhydrolase activity
H0016791molecular_functionphosphatase activity
H0030018cellular_componentZ disc
H0030388biological_processfructose 1,6-bisphosphate metabolic process
H0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
H0042578molecular_functionphosphoric ester hydrolase activity
H0042802molecular_functionidentical protein binding
H0046872molecular_functionmetal ion binding
H0070062cellular_componentextracellular exosome
H0070161cellular_componentanchoring junction
Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA
ChainResidueDetails
AGLY274-ALA286

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:22120740
ChainResidueDetails
AVAL18
CTHR28
CLYS113
CARG141
DVAL18
DTHR28
DLYS113
DARG141
EVAL18
ETHR28
ELYS113
ATHR28
EARG141
FVAL18
FTHR28
FLYS113
FARG141
GVAL18
GTHR28
GLYS113
GARG141
HVAL18
ALYS113
HTHR28
HLYS113
HARG141
AARG141
BVAL18
BTHR28
BLYS113
BARG141
CVAL18

site_idSWS_FT_FI2
Number of Residues80
DetailsBINDING:
ChainResidueDetails
AASP69
AGLU281
BASP69
BGLU98
BASP119
BLEU121
BASP122
BASN213
BTYR245
BTYR265
BLYS275
AGLU98
BGLU281
CASP69
CGLU98
CASP119
CLEU121
CASP122
CASN213
CTYR245
CTYR265
CLYS275
AASP119
CGLU281
DASP69
DGLU98
DASP119
DLEU121
DASP122
DASN213
DTYR245
DTYR265
DLYS275
ALEU121
DGLU281
EASP69
EGLU98
EASP119
ELEU121
EASP122
EASN213
ETYR245
ETYR265
ELYS275
AASP122
EGLU281
FASP69
FGLU98
FASP119
FLEU121
FASP122
FASN213
FTYR245
FTYR265
FLYS275
AASN213
FGLU281
GASP69
GGLU98
GASP119
GLEU121
GASP122
GASN213
GTYR245
GTYR265
GLYS275
ATYR245
GGLU281
HASP69
HGLU98
HASP119
HLEU121
HASP122
HASN213
HTYR245
HTYR265
HLYS275
ATYR265
HGLU281
ALYS275

site_idSWS_FT_FI3
Number of Residues8
DetailsSITE: Important for the conversion from active R-state to inactive T-state in the presence of AMP
ChainResidueDetails
AGLN33
BGLN33
CGLN33
DGLN33
EGLN33
FGLN33
GGLN33
HGLN33

site_idSWS_FT_FI4
Number of Residues16
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1
ChainResidueDetails
ATYR216
ETYR219
FTYR216
FTYR219
GTYR216
GTYR219
HTYR216
HTYR219
ATYR219
BTYR216
BTYR219
CTYR216
CTYR219
DTYR216
DTYR219
ETYR216

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건을2024-03-27부터공개중

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